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Patients: Of a total of 81 patients who were treated with lamivudine, 25 (31%) developed lamivudine resistance during a median follow-up period of 19.3 months. Results: The pretreatment positive rate of HBe antigen, or pretreatment levels of HBVcrAg or HBV DNA did not differ between patients with and without lamivudine resistance. Levels of both 2 HBVcrAg and HBV DNA decreased after the initiation of lamivudine administration; however, the level of HBVcrAg decreased significantly more slowly than that of HBV DNA. The occurrence of lamivudine resistance was significantly less frequent in the 56 patients whose HBV DNA level was less than 2.6 log copy/ml at 6 months of treatment than in the remaining 25 patients. The cumulative rate of lamivudine resistance was as high as 70% within 2 years in the latter group, while it was only 28% in the former group. Lamivudine resistance did not occur during the follow-up period in the 19 patients whose HBVcrAg level was less than 4.6 log U/ml at 6 months of treatment, while it did occur in 50% of the remaining patients within 2 years. Conclusion: These results suggest that measurement of HBV DNA is valuable for identifying patients who are at high risk of developing lamivudine resistance, and that, conversely, measurement of HBVcrAg is valuable for identifying those who are at low risk of lamivudine resistance."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka, E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizokami, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okanoue, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minami, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chayama, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8846", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imamura, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatsuhashi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8848", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagaoka, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yotsuyanagi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawata, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maki, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iino, S", "creatorNameLang": "en"}], "nameIdentifiers": 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Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance
http://hdl.handle.net/10091/225
http://hdl.handle.net/10091/22525e53390-21ca-40ab-8e8c-9848f94a8ae2
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tanaka, E
× Tanaka, E× Matsumoto, A× Suzuki, F× Kobayashi, M× Mizokami, M× Tanaka, Y× Okanoue, T× Minami, M× Chayama, K× Imamura, M× Yatsuhashi, H× Nagaoka, S× Yotsuyanagi, H× Kawata, S× Kimura, T× Maki, N× Iino, S× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | BLACKWELL PUBLISHING | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | LIVER INTERNATIONAL. 26(1): 90-96 (2006) | |||||
書誌情報 |
LIVER INTERNATIONAL 巻 26, 号 1, p. 90-96, 発行日 2006-02 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1478-3223 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11817539 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1478-3231.2005.01200.x | |||||
関連名称 | 10.1111/j.1478-3231.2005.01200.x | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000235135700011 |