{"_buckets": {"deposit": "9f1bf799-015b-4725-9bbe-f5c6a8a313e1"}, "_deposit": {"id": "4047", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4047"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004047", "sets": ["462"]}, "author_link": ["8838", "8839", "8840", "8841", "8842", "8843", "8844", "8845", "8846", "8847", "8848", "8849", "8850", "8851", "8852", "8853", "8854", "8855"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "96", "bibliographicPageStart": "90", "bibliographicVolumeNumber": "26", "bibliographic_titles": [{"bibliographic_title": "LIVER INTERNATIONAL"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "LIVER INTERNATIONAL. 26(1): 90-96 (2006)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Tanaka, E", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000235135700011"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BLACKWELL PUBLISHING"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/j.1478-3231.2005.01200.x"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/j.1478-3231.2005.01200.x", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1478-3223", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1478-3223", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11817539", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "chronic hepatitis B; HBV core-related antigen; HBV DNA; lamivudine resistance"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CLOSED CIRCULAR DNA; VIRAL-DNA; ENZYME-IMMUNOASSAY; PRECORE PROTEIN; YMDD MOTIF; THERAPY; INFECTION; EFFICACY; MUTATION; REPLICATION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Objective: The clinical usefulness of hepatitis B virus core-related antigen (HBVcrAg) assay was compared with that of HBV DNA assay in predicting the occurrence of lamivudine resistance in patients with chronic hepatitis B. Patients: Of a total of 81 patients who were treated with lamivudine, 25 (31%) developed lamivudine resistance during a median follow-up period of 19.3 months. Results: The pretreatment positive rate of HBe antigen, or pretreatment levels of HBVcrAg or HBV DNA did not differ between patients with and without lamivudine resistance. Levels of both 2 HBVcrAg and HBV DNA decreased after the initiation of lamivudine administration; however, the level of HBVcrAg decreased significantly more slowly than that of HBV DNA. The occurrence of lamivudine resistance was significantly less frequent in the 56 patients whose HBV DNA level was less than 2.6 log copy/ml at 6 months of treatment than in the remaining 25 patients. The cumulative rate of lamivudine resistance was as high as 70% within 2 years in the latter group, while it was only 28% in the former group. Lamivudine resistance did not occur during the follow-up period in the 19 patients whose HBVcrAg level was less than 4.6 log U/ml at 6 months of treatment, while it did occur in 50% of the remaining patients within 2 years. Conclusion: These results suggest that measurement of HBV DNA is valuable for identifying patients who are at high risk of developing lamivudine resistance, and that, conversely, measurement of HBVcrAg is valuable for identifying those who are at low risk of lamivudine resistance."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka,  E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizokami,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okanoue,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minami,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chayama,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8846", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imamura,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatsuhashi,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8848", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagaoka,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yotsuyanagi,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawata,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maki,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iino,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8855", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Prediction of lamivudine resistance.pdf", "filesize": [{"value": "139.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 139700.0, "url": {"label": "Prediction of lamivudine resistance.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4047/files/Prediction of lamivudine resistance.pdf"}, "version_id": "ad38702d-842b-431c-a3f9-13bec8c20d81"}]}, "item_language": 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