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Patients: Of a total of 81 patients who were treated with lamivudine, 25 (31%) developed lamivudine resistance during a median follow-up period of 19.3 months. Results: The pretreatment positive rate of HBe antigen, or pretreatment levels of HBVcrAg or HBV DNA did not differ between patients with and without lamivudine resistance. Levels of both 2 HBVcrAg and HBV DNA decreased after the initiation of lamivudine administration; however, the level of HBVcrAg decreased significantly more slowly than that of HBV DNA. The occurrence of lamivudine resistance was significantly less frequent in the 56 patients whose HBV DNA level was less than 2.6 log copy/ml at 6 months of treatment than in the remaining 25 patients. The cumulative rate of lamivudine resistance was as high as 70% within 2 years in the latter group, while it was only 28% in the former group. Lamivudine resistance did not occur during the follow-up period in the 19 patients whose HBVcrAg level was less than 4.6 log U/ml at 6 months of treatment, while it did occur in 50% of the remaining patients within 2 years. Conclusion: These results suggest that measurement of HBV DNA is valuable for identifying patients who are at high risk of developing lamivudine resistance, and that, conversely, measurement of HBVcrAg is valuable for identifying those who are at low risk of lamivudine resistance."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka,  E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8841", 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance

http://hdl.handle.net/10091/225
http://hdl.handle.net/10091/225
25e53390-21ca-40ab-8e8c-9848f94a8ae2
名前 / ファイル ライセンス アクション
Prediction Prediction of lamivudine resistance.pdf (139.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-05-15
タイトル
言語 en
タイトル Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, E

× Tanaka, E

WEKO 8838

en Tanaka, E

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Matsumoto, A

× Matsumoto, A

WEKO 8839

en Matsumoto, A

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Suzuki, F

× Suzuki, F

WEKO 8840

en Suzuki, F

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Kobayashi, M

× Kobayashi, M

WEKO 8841

en Kobayashi, M

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Mizokami, M

× Mizokami, M

WEKO 8842

en Mizokami, M

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Tanaka, Y

× Tanaka, Y

WEKO 8843

en Tanaka, Y

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Okanoue, T

× Okanoue, T

WEKO 8844

en Okanoue, T

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Minami, M

× Minami, M

WEKO 8845

en Minami, M

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Chayama, K

× Chayama, K

WEKO 8846

en Chayama, K

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Imamura, M

× Imamura, M

WEKO 8847

en Imamura, M

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Yatsuhashi, H

× Yatsuhashi, H

WEKO 8848

en Yatsuhashi, H

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Nagaoka, S

× Nagaoka, S

WEKO 8849

en Nagaoka, S

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Yotsuyanagi, H

× Yotsuyanagi, H

WEKO 8850

en Yotsuyanagi, H

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Kawata, S

× Kawata, S

WEKO 8851

en Kawata, S

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Kimura, T

× Kimura, T

WEKO 8852

en Kimura, T

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Maki, N

× Maki, N

WEKO 8853

en Maki, N

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Iino, S

× Iino, S

WEKO 8854

en Iino, S

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Kiyosawa, K

× Kiyosawa, K

WEKO 8855

en Kiyosawa, K

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信州大学研究者総覧へのリンク
氏名 Tanaka, E
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
出版者
出版者 BLACKWELL PUBLISHING
引用
内容記述タイプ Other
内容記述 LIVER INTERNATIONAL. 26(1): 90-96 (2006)
書誌情報 LIVER INTERNATIONAL

巻 26, 号 1, p. 90-96, 発行日 2006-02
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1478-3223
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11817539
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1478-3231.2005.01200.x
関連名称 10.1111/j.1478-3231.2005.01200.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000235135700011
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