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All the patients were Chinese and had hepatitis B virus infection of genotype C. Patients with none of the pre-core or core promoter mutations were significantly (P \u003c 0.001) less common in the group with anti-HBe (13%) than in the group with HBeAg (56%). The complete nucleotide sequence was determined in four anti-HBe-positive patients who had neither pre-core nor core promoter mutations and in five HBeAg-positive patients who also had neither of these mutations (the groups were matched for age and sex). Six mutations were found to be significantly more common in the former group than in the latter: G529A (3/4 vs. 0/5), C934A (4/4 vs. 1/5), A1053G (4/4 vs. 1/5), G1915T/A (4/4 vs. 0/5), T2005C/A (4/4 vs. 0/5), and C3026T (3/4 vs. 0/5). Three of the six mutations were significantly more common in the four anti-HBe-positive patients who had neither pre-core nor core promoter mutations, compared to 11 HBeAg-positive patients who had pre-core and core promoter mutations, and also compared to 15 anti-HBe-positive patients who had pre-core and core promoter mutations, suggesting further the specificity of these mutations. Of the six mutations, two resulted in amino acid substitution in the polymerase protein, and one is located near the enhancer I region. The results suggest that the six newly discovered mutations are associated with HBeAg negativity. (c) 2005 Wiley-Liss, Inc."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sun, XH", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rokuhara, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gad, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mutou, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8863", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Mutations in HB e antigen negativity.pdf", "filesize": [{"value": "197.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 197700.0, "url": {"label": "Mutations in HB e antigen negativity.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4048/files/Mutations in HB e antigen negativity.pdf"}, "version_id": "d939ada7-6f39-425f-b4c4-bdf6babaf7db"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nucleotide mutations associated with hepatitis B e antigen negativity", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Nucleotide mutations associated with hepatitis B e antigen negativity", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/224", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-14"}, "publish_date": "2007-05-14", "publish_status": "0", "recid": "4048", "relation": {}, "relation_version_is_last": true, "title": ["Nucleotide mutations associated with hepatitis B e antigen negativity"], "weko_shared_id": -1}
Nucleotide mutations associated with hepatitis B e antigen negativity
http://hdl.handle.net/10091/224
141b0ff3-ca06-4d1c-8a75-f43aa639752b
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Nucleotide mutations associated with hepatitis B e antigen negativity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sun, XH
× Sun, XH× Rokuhara, A× Tanaka, E× Gad, A× Mutou, H× Matsumoto, A× Yoshizawa, K× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | WILEY-LISS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF MEDICAL VIROLOGY. 76(2): 170-175 (2005) | |||||
書誌情報 |
JOURNAL OF MEDICAL VIROLOGY 巻 76, 号 2, p. 170-175, 発行日 2005-06 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Copyright © 2005 Wiley-Liss, Inc., A Wiley Company | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0146-6615 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00702400 | |||||
他の資源との関係:URI | ||||||
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識別子タイプ | URI | |||||
関連識別子 | http://www3.interscience.wiley.com/cgi-bin/jhome/32763?CRETRY=1&SRETRY=0 | |||||
関連名称 | ||||||
関連名称 | http://www3.interscience.wiley.com/cgi-bin/jhome/32763?CRETRY=1&SRETRY=0 | |||||
DOI | ||||||
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識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/jmv.20340 | |||||
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関連名称 | 10.1002/jmv.20340 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000228783600006 |