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Changes in the serum hepatitis B virus (HBV) RNA level during lamivudine therapy were compared to those in the serum HBV DNA and HBV core-related antigen (HBVcrAg) levels in 24 patients with chronic hepatitis B. MEthods. For measurement of HBV RNA, total nucleic acid was extracted from serum samples and treated with RNase-free DNase I. After cDNA synthesis from extracted RNA, HBV RNA was measured by real-time detection polymerase chain reaction. Results. The peak fraction of HBV RNA in serum samples was consistent with peak fractions of HBV DNA and HBV core protein in a sucrose gradient analysis, indicating that HBV RNA was incorporated into virus particles. All levels of HBV DNA, HBV RNA, and HBVcrAg decreased gradually during lamivudine therapy (P \u003c 0.001 for all). The amount of decrease from the start of lamivudine therapy was significantly higher for HBV DNA than for HBV RNA or HBVcrAg during 6 months of lamivudine therapy (P \u003c 0.001 for all). However, a similar difference was not seen between HBV RNA and HBVcrAg levels during that period. The HBV RNA level was significantly correlated (P \u003c 0.001 for all) with levels of HBV DNA and HBVcrAg both at the beginning and 2 months after the start of lamivudine therapy. Conclusions. HBV RNA is detectable in serum in a form indicating incorporation into virus particles, and its serum level might serve as a new viral marker with a significance different from that of HBV DNA in lamivudine therapy."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Rokuhara, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umemura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maki, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8899", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HBV RNA measurement in serum.pdf", "filesize": [{"value": "195.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 195700.0, "url": {"label": "HBV RNA measurement in serum.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4052/files/HBV RNA measurement in serum.pdf"}, "version_id": "f1f05d11-9eb7-4f6b-a596-62422c5fd8de"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/220", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-14"}, "publish_date": "2007-05-14", "publish_status": "0", "recid": "4052", "relation": {}, "relation_version_is_last": true, "title": ["Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy"], "weko_shared_id": -1}
Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy
http://hdl.handle.net/10091/220
http://hdl.handle.net/10091/220019e7ff9-7433-407c-9fbe-665d00aac313
名前 / ファイル | ライセンス | アクション |
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HBV RNA measurement in serum.pdf (195.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00535-006-1856-4 | |||||
関連名称 | 10.1007/s00535-006-1856-4 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Rokuhara, A
× Rokuhara, A× Matsumoto, A× Tanaka, E× Umemura, T× Yoshizawa, K× Kimura, T× Maki, N× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | SPRINGER TOKYO | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF GASTROENTEROLOGY. 41(8): 785-790 (2006) | |||||
書誌情報 |
JOURNAL OF GASTROENTEROLOGY 巻 41, 号 8, p. 785-790, 発行日 2006-09 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0944-1174 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10988015 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000240797900010 |