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One reason for the poor outcome in ANKL is leukemic infiltration into multiple organs. The mechanisms of cell trafficking associated with the chemokine system have been investigated in NK cells. To clarify the mechanism of systemic migration of leukemic NK cells, we enrolled nine ANKL and six CNKL cases, and analyzed the expression profiles and functions of chemokine receptors by flowcytometry and chemotaxis assay. CXCR1 was detected on NK cells in all groups, and CCR5 was positive in all ANKL cells. Proliferating NK cells were simultaneously positive for CXCR1 and CCR5 in all ANKL patients examined, and NK cells with this phenotype did not expand in CNKL patients or healthy donors. ANKL cells showed enhanced chemotaxis toward the ligands of these receptors. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Significance of chemokine receptor expression in aggressive NK cell leukemia

http://hdl.handle.net/10091/217
http://hdl.handle.net/10091/217
87c55da6-139a-4692-adad-3c7978900f13
名前 / ファイル ライセンス アクション
Chemokine Chemokine receptors in ANKL.pdf (413.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-05-14
タイトル
言語 en
タイトル Significance of chemokine receptor expression in aggressive NK cell leukemia
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Makishima, H

× Makishima, H

WEKO 8916

en Makishima, H

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Ito, T

× Ito, T

WEKO 8917

en Ito, T

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Asano, N

× Asano, N

WEKO 8918

en Asano, N

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Nakazawa, H

× Nakazawa, H

WEKO 8919

en Nakazawa, H

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Shimodaira, S

× Shimodaira, S

WEKO 8920

en Shimodaira, S

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Kamijo, Y

× Kamijo, Y

WEKO 8921

en Kamijo, Y

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Nakazawa, Y

× Nakazawa, Y

WEKO 8922

en Nakazawa, Y

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Suzuki, T

× Suzuki, T

WEKO 8923

en Suzuki, T

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Kobayashi, H

× Kobayashi, H

WEKO 8924

en Kobayashi, H

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Kiyosawa, K

× Kiyosawa, K

WEKO 8925

en Kiyosawa, K

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Ishida, F

× Ishida, F

WEKO 8926

en Ishida, F

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出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 LEUKEMIA. 19(7): 1169-1174 (2005)
書誌情報 LEUKEMIA

巻 19, 号 7, p. 1169-1174, 発行日 2005-07
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0887-6924
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10668706
他の資源との関係:URI
識別子タイプ URI
関連識別子 http://www.nature.com/leu/index.html
関連名称 http://www.nature.com/leu/index.html
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/sj.leu.2403732
関連名称 10.1038/sj.leu.2403732
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000229957400009
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