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Systemic resiniferatoxin (RTX) pretreatment can block resiniferatoxin-sensitive (C-fiber) nerve-mediated bladder overactivity, such as that induced by intravesical administration of acetic acid. The effects of pretreatment with goshajinkigan and RTX alone or in combination on acetic acid-induced bladder overactivity in conscious rats were also compared. Female SD rats were divided into four groups. Groups I and 3 received normal food for 4 weeks, while groups 2 and 4 received goshajinkigan (0.09 g/kg/day) during the same period. Two days after bladder catheterization, groups 3 and 4 received RTX (0.3 mg/kg) injection, while groups I and 2 received vehicle alone. Cystometric investigations were performed on all animals 24 hours after RTX or vehicle injection. The effects of intravesical instillation of acetic acid (pH = 4.0) were compared with those of intravesical saline. Goshajinkigan significantly increased threshold pressure, voiding interval, micturition volume, and bladder capacity. Intravesical instillation of acetic acid induced bladder overactivity in both normal rats and in those pretreated with goshajinkigan. However, the effects of acetic acid on voiding interval and micturition volume were significantly different between rats given normal diet and those pretreated with goshajinkigan. The effect of acetic acid was not different between goshajinkigan- and RTX-pretreated rats. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Effects of goshajinkigan (Niu-Che-Sen-Qi-Wan) for resiniferatoxin-sensitive afferents on detrusor overactivity induced by acetic acid in conscious rats

http://hdl.handle.net/10091/214
http://hdl.handle.net/10091/214
2768bec0-d785-432c-9dbd-fb026924ed8f
名前 / ファイル ライセンス アクション
Effects Effects of goshajinkigan.pdf (205.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-05-10
タイトル
言語 en
タイトル Effects of goshajinkigan (Niu-Che-Sen-Qi-Wan) for resiniferatoxin-sensitive afferents on detrusor overactivity induced by acetic acid in conscious rats
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Zhang, XY

× Zhang, XY

WEKO 8933

en Zhang, XY

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Ishizuka, O

× Ishizuka, O

WEKO 8934

en Ishizuka, O

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Tanabe, T

× Tanabe, T

WEKO 8935

en Tanabe, T

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Satoh, T

× Satoh, T

WEKO 8936

en Satoh, T

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Nakayama, T

× Nakayama, T

WEKO 8937

en Nakayama, T

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Imamura, T

× Imamura, T

WEKO 8938

en Imamura, T

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Nishizawa, O

× Nishizawa, O

WEKO 8939

en Nishizawa, O

Search repository
信州大学研究者総覧へのリンク
氏名 Ishizuka, O
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, O
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 WORLD SCIENTIFIC PUBL CO PTE LTD
引用
内容記述タイプ Other
内容記述 American Journal of Chinese Medicine. 34(2): 285-293 (2006)
書誌情報 American journal of Chinese medicine

巻 34, 号 2, p. 285-293, 発行日 2006
内容記述
内容記述タイプ Other
内容記述 Electronic version of an article published as [AMERICAN JOURNAL OF CHINESE MEDICINE, 34, 2, 2006, 285-293] [doi:10.1142/S0192415X06003837] © [copyright World Scientific Publishing Company] [http://www.worldscinet.com/ajcm/ajcm.shtml]
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0192-415X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00066285
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1142/S0192415X06003837
関連名称 10.1142/S0192415X06003837
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000237153500011
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