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Analysis of plasma or purified fibrinogen from the heterozygous propositus revealed that the amount of variant gamma-chain was lower than that of normal gamma-chain. In order to examine the basis for this difference, we transfected Chinese hamster ovary cells and established stable cell lines that expressed both chains, gamma Delta/gamma N, only the normal chain, gamma N, and only the variant chain, gamma Delta. We measured fibrinogen concentration of confluent cultures by ELISA. We found the ratios of the concentrations in the media to the concentrations in the cell lysates of gamma Delta, gamma Delta/gamma N, and gamma N-cells were 0.42, 0.60, and 1.00, respectively. We measured the concentrations of the gamma Delta and gamma N chains by densitometric analysis of samples following separation by SIDS-PAGE and found the fraction of gamma Delta-chains in cell lysates was always greater than the fraction in the respective culture media. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

In vitro expression demonstrates impaired secretion of the gamma Asn319, Asp320 deletion variant fibrinogen

http://hdl.handle.net/10091/193
http://hdl.handle.net/10091/193
5ce314c2-21d7-4047-ab2d-8d6e21e41cf4
名前 / ファイル ライセンス アクション
Rv-Kani.pdf Rv-Kani.pdf (636.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-25
タイトル
言語 en
タイトル In vitro expression demonstrates impaired secretion of the gamma Asn319, Asp320 deletion variant fibrinogen
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kani, S

× Kani, S

WEKO 8959

en Kani, S

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Terasawa, F

× Terasawa, F

WEKO 8960

en Terasawa, F

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Lord, ST

× Lord, ST

WEKO 8961

en Lord, ST

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Tozuka, M

× Tozuka, M

WEKO 8962

en Tozuka, M

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Ota, H

× Ota, H

WEKO 8963

en Ota, H

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Okumura, N

× Okumura, N

WEKO 8964

en Okumura, N

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Katsuyama, T

× Katsuyama, T

WEKO 8965

en Katsuyama, T

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信州大学研究者総覧へのリンク
氏名 Ota, H
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html
信州大学研究者総覧へのリンク
氏名 Okumura, N
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html
出版者
出版者 SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
引用
内容記述タイプ Other
内容記述 THROMBOSIS AND HAEMOSTASIS. 94(1): 53-59 (2005)
書誌情報 Thrombosis and Haemostasis

巻 94, 号 1, p. 53-59, 発行日 2005-07
内容記述
内容記述タイプ Other
内容記述 This article is not an exact copy of the original published article in [THROMBOSIS AND HAEMOSTASIS]. The definitive publisher-authenticated version of [THROMBOSIS AND HAEMOSTASIS 94;53-59,2005] is available online at: [http://www.schattauer.de/]
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0340-6245
書誌レコードID
識別子タイプ NCID
関連識別子 BA20605267
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1160/TH05-02-0134
関連名称 10.1160/TH05-02-0134
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000230516600008
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