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To eliminate the influence of plasma heterozygous molecules, we synthesized and analyzed recombinant-variant fibrinogens. Methods: We synthesized two recombinant-variant fibrinogens with a single amino acid substitution at the 15Gly residue in the Bβ-chain: namely, Bβ 15Cys and Bβ 15Ala. Results: Western blotting analysis of purified fibrinogen revealed the existence of a small amount of a dimeric form only for Bβ 15Cys fibrinogen. For Bβ 15Cys fibrinogen, functional analysis indicated (a) no thrombi n-catalyzed fibrinopeptide B (FPB) release and (b) markedly impaired lateral aggregation in thrombin- and reptilase-catalyzed fibrin polymerizations. For Bβ 15Ala fibrinogen, such analysis indicated slight impairments of both thrombin-catalyzed FPB release and lateral aggregation in thrombin-catalyzed fibrin polymerization, but nearly normal lateral aggregation in reptilase-catalyzed fibrin polymerization. These impaired lateral aggregations were accompanied by thinner fibrin fiber diameters (determined by scanning electron microscopy of the corresponding fibrin clots). Conclusion: We conclude that a region adjacent to Bβ 15Gly plays important roles in lateral aggregation not only in desA fibrin polymerization, but also in desAB fibrin polymerization, and we speculate that the marked functional differences between Bβ 15A and Bβ 15C fibrinogens in FPB release and fibrin polymerization might not only be due to the presence of a substituted cysteine residue in BP I 5C fibrinogen, but also to the existence of disulfide-bonded forms. Finally, our data indicate that the Bβ 15Gly residue plays important roles in FPB release and lateral aggregation of protofibrils."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirota-Kawadobora, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kani, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terasawa, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujihara, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamauchi, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tozuka, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8981", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8982", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JTH-rBb15CA.pdf", "filesize": [{"value": "638.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 638900.0, "url": {"label": "JTH-rBb15CA.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4063/files/JTH-rBb15CA.pdf"}, "version_id": "0d8d72b4-816a-4235-8966-4362e647ea1b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/190", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-25"}, "publish_date": "2007-04-25", "publish_status": "0", "recid": "4063", "relation": {}, "relation_version_is_last": true, "title": ["Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils"], "weko_shared_id": -1}
Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils
http://hdl.handle.net/10091/190
http://hdl.handle.net/10091/19046b93a5e-096a-40fd-80f1-edc97b6732c8
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hirota-Kawadobora, M
× Hirota-Kawadobora, M× Kani, S× Terasawa, F× Fujihara, N× Yamauchi, K× Tozuka, M× Okumura, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Okumura, N | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html | |||||
出版者 | ||||||
出版者 | BLACKWELL PUBL LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 3(5): 983-990 (2005) | |||||
書誌情報 |
Journal of thrombosis and haemostasis 巻 3, 号 5, p. 983-990, 発行日 2005-05 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The definitive version is available at www.blackwell-synergy.com. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1538-7933 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11811179 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1538-7836.2005.01294.x | |||||
関連名称 | 10.1111/j.1538-7836.2005.01294.x | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000229132000029 |