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To eliminate the influence of plasma heterozygous molecules, we synthesized and analyzed recombinant-variant fibrinogens. Methods: We synthesized two recombinant-variant fibrinogens with a single amino acid substitution at the 15Gly residue in the Bβ-chain: namely, Bβ 15Cys and Bβ 15Ala. Results: Western blotting analysis of purified fibrinogen revealed the existence of a small amount of a dimeric form only for Bβ 15Cys fibrinogen. For Bβ 15Cys fibrinogen, functional analysis indicated (a) no thrombi n-catalyzed fibrinopeptide B (FPB) release and (b) markedly impaired lateral aggregation in thrombin- and reptilase-catalyzed fibrin polymerizations. For Bβ 15Ala fibrinogen, such analysis indicated slight impairments of both thrombin-catalyzed FPB release and lateral aggregation in thrombin-catalyzed fibrin polymerization, but nearly normal lateral aggregation in reptilase-catalyzed fibrin polymerization. These impaired lateral aggregations were accompanied by thinner fibrin fiber diameters (determined by scanning electron microscopy of the corresponding fibrin clots). Conclusion: We conclude that a region adjacent to Bβ 15Gly plays important roles in lateral aggregation not only in desA fibrin polymerization, but also in desAB fibrin polymerization, and we speculate that the marked functional differences between Bβ 15A and Bβ 15C fibrinogens in FPB release and fibrin polymerization might not only be due to the presence of a substituted cysteine residue in BP I 5C fibrinogen, but also to the existence of disulfide-bonded forms. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils

http://hdl.handle.net/10091/190
http://hdl.handle.net/10091/190
46b93a5e-096a-40fd-80f1-edc97b6732c8
名前 / ファイル ライセンス アクション
JTH-rBb15CA.pdf JTH-rBb15CA.pdf (638.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-25
タイトル
言語 en
タイトル Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hirota-Kawadobora, M

× Hirota-Kawadobora, M

WEKO 8976

en Hirota-Kawadobora, M

Search repository
Kani, S

× Kani, S

WEKO 8977

en Kani, S

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Terasawa, F

× Terasawa, F

WEKO 8978

en Terasawa, F

Search repository
Fujihara, N

× Fujihara, N

WEKO 8979

en Fujihara, N

Search repository
Yamauchi, K

× Yamauchi, K

WEKO 8980

en Yamauchi, K

Search repository
Tozuka, M

× Tozuka, M

WEKO 8981

en Tozuka, M

Search repository
Okumura, N

× Okumura, N

WEKO 8982

en Okumura, N

Search repository
信州大学研究者総覧へのリンク
氏名 Okumura, N
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html
出版者
出版者 BLACKWELL PUBL LTD
引用
内容記述タイプ Other
内容記述 JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 3(5): 983-990 (2005)
書誌情報 Journal of thrombosis and haemostasis

巻 3, 号 5, p. 983-990, 発行日 2005-05
内容記述
内容記述タイプ Other
内容記述 The definitive version is available at www.blackwell-synergy.com.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1538-7933
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11811179
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1538-7836.2005.01294.x
関連名称 10.1111/j.1538-7836.2005.01294.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000229132000029
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