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Only the variant gamma 387Asp showed impaired synthesis in the cells and very low secretion into the medium. In addition, we performed thrombin-catalyzed fibrin polymerization and factor (F) XIIIa-catalyzed cross-linking of the gamma-chain for 4 variants. The degree of lateral aggregation of proto-fibrils into fibrin fibers was slightly reduced for gamma 387Arg and Ala, and moderately reduced for gamma 387Leu and Met. Although the FXIIIa-catalyzed cross-linking for all of the variants was slower than that for gamma 387Ile, that of gamma 387Arg was much more markedly impaired than that of the others. In summary, our studies demonstrated that the specific residue at gamma 387 or the conformation of gamma 388-411 residues, but not the length of the gamma C tail, is critical for fibrinogen assembly and subsequent secretion. Moreover, this residue or the conformation is also important for not only the lateral aggregation of fibrin polymers but also the FXIIIa-catalyzed cross-linking of the gamma-chain. 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Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation
http://hdl.handle.net/10091/189
http://hdl.handle.net/10091/189d5c07c61-9de2-47d9-a269-1d2134e40267
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kani, S
× Kani, S× Terasawa, F× Yamauchi, K× Tozuka, M× Okumura, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Okumura, N | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html | |||||
出版者 | ||||||
出版者 | AMER SOC HEMATOLOGY | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BLOOD. 108(6): 1887-1894 (2006) | |||||
書誌情報 |
Blood 巻 108, 号 6, p. 1887-1894, 発行日 2006-09-15 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This research was originally published in Blood. Author(s).Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N. Title. Blood. 2006;108:1887-1894. © by the American Society of Hematology. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0006-4971 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00567156 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1182/blood-2006-04-016485 | |||||
関連名称 | 10.1182/blood-2006-04-016485 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000240394800024 |