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Only the variant gamma 387Asp showed impaired synthesis in the cells and very low secretion into the medium. In addition, we performed thrombin-catalyzed fibrin polymerization and factor (F) XIIIa-catalyzed cross-linking of the gamma-chain for 4 variants. The degree of lateral aggregation of proto-fibrils into fibrin fibers was slightly reduced for gamma 387Arg and Ala, and moderately reduced for gamma 387Leu and Met. Although the FXIIIa-catalyzed cross-linking for all of the variants was slower than that for gamma 387Ile, that of gamma 387Arg was much more markedly impaired than that of the others. In summary, our studies demonstrated that the specific residue at gamma 387 or the conformation of gamma 388-411 residues, but not the length of the gamma C tail, is critical for fibrinogen assembly and subsequent secretion. Moreover, this residue or the conformation is also important for not only the lateral aggregation of fibrin polymers but also the FXIIIa-catalyzed cross-linking of the gamma-chain. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation

http://hdl.handle.net/10091/189
d5c07c61-9de2-47d9-a269-1d2134e40267
名前 / ファイル ライセンス アクション
BLOODmanuscript.pdf BLOODmanuscript.pdf (909.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-25
タイトル
言語 en
タイトル Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kani, S

× Kani, S

WEKO 8983

en Kani, S

Search repository
Terasawa, F

× Terasawa, F

WEKO 8984

en Terasawa, F

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Yamauchi, K

× Yamauchi, K

WEKO 8985

en Yamauchi, K

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Tozuka, M

× Tozuka, M

WEKO 8986

en Tozuka, M

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Okumura, N

× Okumura, N

WEKO 8987

en Okumura, N

Search repository
信州大学研究者総覧へのリンク
氏名 Okumura, N
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html
出版者
出版者 AMER SOC HEMATOLOGY
引用
内容記述タイプ Other
内容記述 BLOOD. 108(6): 1887-1894 (2006)
書誌情報 Blood

巻 108, 号 6, p. 1887-1894, 発行日 2006-09-15
内容記述
内容記述タイプ Other
内容記述 This research was originally published in Blood. Author(s).Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N. Title. Blood. 2006;108:1887-1894. © by the American Society of Hematology.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0006-4971
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00567156
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1182/blood-2006-04-016485
関連名称
関連名称 10.1182/blood-2006-04-016485
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000240394800024
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