{"_buckets": {"deposit": "352a093e-44e4-49e4-89a0-e9f1dbf51e6d"}, "_deposit": {"id": "4066", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4066"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004066"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "177", "bibliographicPageStart": "173", "bibliographicVolumeNumber": "97", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY"}]}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 97(1-2): 173-177 (2005)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Kawa, S", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000233543100022"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "PERGAMON-ELSEVIER SCIENCE LTD"}]}, "item_6_relation_46": {"attribute_name": "\u4ed6\u306e\u8cc7\u6e90\u3068\u306e\u95a2\u4fc2\uff1aURI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.jsbmb.2005.06.021"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1016/j.jsbmb.2005.06.021", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0960-0760", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0960-0760", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1077779X", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "maxacalcitol; 22-oxa-1,25-dihydroxyvitamin D-3; calcitriol; 1,25-dihydroxyvitamin D-3; pancreatic cancer"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "MYELOID-LEUKEMIA CELLS; CDK INHIBITOR; IN-VIVO; P21; DIFFERENTIATION; GROWTH; ANALOG; GENE; 1-ALPHA,25-DIHYDROXYVITAMIN-D3; 1,25-DIHYDROXYVITAMIN-D(3)"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Effective chemotherapy for pancreatic cancer is urgently needed. The aim of this study was to compare the anti-proliferative activity on pancreatic cancer cell lines of the vitamin D-3 analog, 22-oxa-1,25-dihydroxyvitamin D3, maxacalcitol, with that of 1,25-dihydroxyvitamin D3, calcitriol, with analysis of vitamin D receptor status and the G(1)-phase cell cycle-regulating factors. Antiproliferative effects of both agents were compared using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and by measuring the tumor size of xenografts inoculated into athymic mice. Scatchard analysis of vitamin D receptor contents, and mutational analysis of receptor complementary DNA were performed. Levels of expression of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors, p21 and p27, were analysed by western blotting. In vitro, maxacalcitol and calcittiol markedly inhibited the proliferation and caused a G, phase cell cycle arrest with the appearance of numerous domes. In vivo, maxacalcitol inhibited the growth of BxPC-3 xenografts more significantly than calcitriol, without inducing hypercalcemia. Responsive cells had abundant functional vitamin D receptors. However, Hs 766T, showing no response to either agent, had the second highest receptor contents with no abnormalities in its primary structure deduced by receptor complementary DNA. In the responsive cells, p21 and p27 were markedly up-regulated after 24 h of treatment with both agents. In non-responsive cells, no such changes were observed. In conclusion, maxacalcitol and calcitriol up-regulate p21 and p27 as an early event, which in turn could block the G(1)/S transition and induce growth inhibition in responsive cells, and maxacalcitol may provide a more useful tool for the chemotherapy of pancreatic cancer than calcittiol because of its low toxicity. (c) 2005 Elsevier Ltd. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawa,  S"}], "nameIdentifiers": [{"nameIdentifier": "8996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa,  K"}], "nameIdentifiers": [{"nameIdentifier": "8997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nikaido,  T"}], "nameIdentifiers": [{"nameIdentifier": "8998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa,  K"}], "nameIdentifiers": [{"nameIdentifier": "8999", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "OCT on Pancreatic Cance 7 .pdf", "filesize": [{"value": "107.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 107500.0, "url": {"label": "OCT on Pancreatic Cance 7 .pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4066/files/OCT on Pancreatic Cance 7 .pdf"}, "version_id": "b7c3fbf7-138e-4571-b32f-10f7a6b3c2bc"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/171", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2007-04-19"}, "publish_date": "2007-04-19", "publish_status": "0", "recid": "4066", "relation": {}, "relation_version_is_last": true, "title": ["Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines"], "weko_shared_id": 3}