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The aim of this study was to compare the anti-proliferative activity on pancreatic cancer cell lines of the vitamin D-3 analog, 22-oxa-1,25-dihydroxyvitamin D3, maxacalcitol, with that of 1,25-dihydroxyvitamin D3, calcitriol, with analysis of vitamin D receptor status and the G(1)-phase cell cycle-regulating factors. Antiproliferative effects of both agents were compared using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and by measuring the tumor size of xenografts inoculated into athymic mice. Scatchard analysis of vitamin D receptor contents, and mutational analysis of receptor complementary DNA were performed. Levels of expression of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors, p21 and p27, were analysed by western blotting. In vitro, maxacalcitol and calcittiol markedly inhibited the proliferation and caused a G, phase cell cycle arrest with the appearance of numerous domes. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines

http://hdl.handle.net/10091/171
0c0c3105-4a87-4889-9632-42479d600ab5
名前 / ファイル ライセンス アクション
OCT OCT on Pancreatic Cance 7 .pdf (107.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-19
タイトル
言語 en
タイトル Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kawa, S

× Kawa, S

WEKO 8996

en Kawa, S

Search repository
Yoshizawa, K

× Yoshizawa, K

WEKO 8997

en Yoshizawa, K

Search repository
Nikaido, T

× Nikaido, T

WEKO 8998

en Nikaido, T

Search repository
Kiyosawa, K

× Kiyosawa, K

WEKO 8999

en Kiyosawa, K

Search repository
信州大学研究者総覧へのリンク
氏名 Kawa, S
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html
出版者
出版者 PERGAMON-ELSEVIER SCIENCE LTD
引用
内容記述タイプ Other
内容記述 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 97(1-2): 173-177 (2005)
書誌情報 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

巻 97, 号 1-2, p. 173-177, 発行日 2005-10
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0960-0760
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA1077779X
他の資源との関係:URI
関連識別子
識別子タイプ URI
関連識別子 http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description
関連名称
関連名称 http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jsbmb.2005.06.021
関連名称
関連名称 10.1016/j.jsbmb.2005.06.021
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000233543100022
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