{"_buckets": {"deposit": "515a99db-6372-49b1-8111-29a767c1efb5"}, "_deposit": {"id": "4069", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4069"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004069", "sets": ["462"]}, "author_link": ["9015", "9016", "9017", "9018"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "188", "bibliographicPageStart": "165", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "Pharmacology \u0026 therapeutics"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}, {"subitem_description": "application/pdf", "subitem_description_type": "Other"}, {"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Pharmacology \u0026 therapeutics. 2005;105(2):165-188", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Ohhashi, T", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HFApOFkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026KeyUT=000226930900006\u0026DestApp=WOS"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_6_relation_46": {"attribute_name": "他の資源との関係：URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.elsevier.com/locate/inca/525486"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/locate/inca/525486", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "15670625"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/15670625", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.pharmthera.2004.10.009"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.pharmthera.2004.10.009", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0163-7258", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0163-7258", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00361944", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "lymphatic system; spontaneous contraction; lymphatic endothelial cell; oxygen tension; nitric oxide; prostaglandins; reactive oxygen radicals; K-ATP channel; tumor-derived chemical substance; ATP; adenosine; PTHr-P"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "BOVINE MESENTERIC LYMPHATICS; HORMONE-RELATED PROTEIN; NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; HUMAN-ENDOTHELIAL CELLS; SENSITIVE K+ CHANNELS; CANINE THORACIC-DUCT; RHO-KINASE PATHWAY; LONG-TERM CULTURE; PARATHYROID-HORMONE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "We have reviewed physiological significance of rhythmical spontaneous contractions of collecting lymph vessels. which play a pivotal role in lymph transport and seem to control lymph formation through changing the pacemaker sites of the rhythmic contractions and contractile patterns of the lymphangions. A characteristic feature that the rhythmic pump activity works in vivo physiologically under the specific environment of lower oxygen tension in lymph (25-40 mm Hg) has been evaluated. With the characteristic feature. generation of endogenous nitric oxide (NO) from lymphatic endothelial cells and/or activation of ATP-sensitive potassium channels (K-ATP) are reviewed to play crucial roles in the regulation of lymph transport at physiological or pathophysiological conditions. Chemical substances released front malignant tumor cells and tumor-derived parathyroid hormone-related peptide (PTHr-P) are also shown to cause a significant reduction of lymphatic pump activity through generation of endogenous NO and activation of K-ATP channels. Finally. we have discussed physiological significance and roles of the lower oxygen tension in lymph. generation of endogenous NO. and activation of K-ATP in lymph formation. lymph transport, and the functions of lymph nodes. (C) 2004 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohhashi,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno,  R", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikomi,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawai,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9018", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "6body.pdf", "filesize": [{"value": "637.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 637500.0, "url": {"label": "6body.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4069/files/6body.pdf"}, "version_id": "dfcd280b-20c6-4e1c-9e01-bb4a9dce558c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "6figs(1-6).pdf", "filesize": [{"value": "5.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 5900000.0, "url": {"label": "6figs(1-6).pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4069/files/6figs(1-6).pdf"}, "version_id": "ec5b0bda-71d7-4ab0-a6c1-4aadc6ce9842"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "6figs(7-11).pdf", "filesize": [{"value": "4.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 4900000.0, "url": {"label": "6figs(7-11).pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4069/files/6figs(7-11).pdf"}, "version_id": "1fe21c73-d5d9-4fdd-b861-2aee0b584c00"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Current topics of physiology and pharmacology in the lymphatic system", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Current topics of physiology and pharmacology in the lymphatic system", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/117", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-02-20"}, "publish_date": "2007-02-20", "publish_status": "0", "recid": "4069", "relation": {}, "relation_version_is_last": true, "title": ["Current topics of physiology and pharmacology in the lymphatic system"], "weko_shared_id": -1}