Item type |
紀要論文 / Departmental Bulletin Paper(1) |
公開日 |
2012-01-04 |
タイトル |
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タイトル |
Phase II Trial of Biweekly Paclitaxel and Gemcitabine as Second-Line Chemotherapy for Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy |
言語 |
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言語 |
eng |
DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.11441/shinshumedj.59.411 |
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関連名称 |
10.11441/shinshumedj.59.411 |
キーワード |
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主題 |
second-line chemotherapy, platinum-resistant, non-small cell lung cancer, neurotoxicity |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
departmental bulletin paper |
著者 |
KOBAYASHI, Takashi
KOIZUMI, Tomonobu
YASUO, Masanori
TSUSHIMA, Kenji
YAMAMOTO, Hiroshi
KUBO, Keishi
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信州大学研究者総覧へのリンク |
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氏名 |
KOIZUMI, Tomonobu |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
YASUO, Masanori |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html |
出版者 |
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出版者 |
信州医学会 |
引用 |
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内容記述 |
信州医学雑誌 59(6): 411-418(2011) |
書誌情報 |
信州医学雑誌
巻 59,
号 6,
p. 411-418,
発行日 2011-12-10
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抄録 |
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内容記述 |
A phase II study was conducted to evaluate the feasibility and efficacy of biweekly administration of paclitaxel and gemcitabine in patients with non-small cell lung cancer (NSCLC) who had been treated previously with platinum-based chemotherapy. Paclitaxel (150 mg/m2) and gemcitabine (1,000 mg/m2) were administered biweekly for at least 4 cycles. Thirty-one patients with a median age of 64 years (39-75 years) were enrolled in this study(stage IIIB/IV :11/20,PS 0/1/2:13/16/2).Partial response was observed in 7 cases (23%), and stable disease was seen in 18 cases (58%).Median survival time was 8.8 months with a one-year survival rate of 41.9 %.Hematological toxicities were mild and neutropenia of grade 3 or above was observed in one patient (3%). Non-hematological toxicities were also mild, including neurotoxicity (3%). Biweekly paclitaxel and gemcitabine combination chemotherapy was effective and tolerated well as second-line therapy against NSCLC. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0037-3826 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00120815 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |