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Comparison of Hepatitis B Virus DNA, RNA, and Core Related Antigen as Predictors of Lamivudine Resistance in Patients with Chronic Hepatitis B
http://hdl.handle.net/10091/10292
http://hdl.handle.net/10091/102920edbb52a-6ec8-4022-8957-97e35786652e
| 名前 / ファイル | ライセンス | アクション |
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Medicine_Vo,58No.4-2.pdf (898.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2010-08-17 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Comparison of Hepatitis B Virus DNA, RNA, and Core Related Antigen as Predictors of Lamivudine Resistance in Patients with Chronic Hepatitis B | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 関連識別子 | https://doi.org/10.11441/shinshumedj.58.153 | |||||||||||||||||
| 関連名称 | 10.11441/shinshumedj.58.153 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | hepatitis B virus, HBV core related antigen, HBV RNA, lamivudine, breakthrough | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | departmental bulletin paper | |||||||||||||||||
| 著者 |
MATSUMOTO, Akihiro
× MATSUMOTO, Akihiro
× MAKI, Noboru
× YOSHIZAWA, Kaname
× UMEMURA, Takeji
× JOSHITA, Satoru
× TANAKA, Eiji
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | UMEMURA, Takeji | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | JOSHITA, Satoru | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | TANAKA, Eiji | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | 信州医学会 | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | 信州医学雑誌, 58(4):153-162 (2010) | |||||||||||||||||
| 書誌情報 |
信州医学雑誌 巻 58, 号 4, p. 153-162, 発行日 2010-08-10 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | The clinical usefulness of hepatitis B virus (HBV)DNA, RNA, and core related antigen (HBcrAg)assays for predicting the appearance of HBV DNA breakthrough was evaluated and compared in patients with chronic hepatitis B undergoing lamivudine therapy.Methods :Thirty six patients with chronic hepatitis B who received lamivudine therapy for more than 1 year were enrolled. HBV RNA was measured simultaneously with HBV DNA (HBV RNA/DNA) using a real-time detection polymerase chain reaction assay with a preceding step of reverse-transcription. HBV DNA was measured by an HBV AMPLICOR monitor kit. HBcrAg was measured using a chemiluminescence enzyme immunoassay. Results : Sixteen patients (44%) developed HBV DNA breakthrough during the median observation period of 48.4 months (range 7.4-87.8 months). Afterwards, HBV DNA breakthrough was prospected using the three parameters taken 6 months after starting lamivudine therapy. The cut-offlevels for predictions were determined by receiver operating characteristic curves, and were 2.6 log copies/ml for HBV DNA, 3.8 log U/ml for HBV RNA/DNA, and 4.0 log U/ml for HBcrAg.Sensitivity,specificity,and accuracy for predicting HBV DNA breakthrough were 25%, 100%,and 67% respectively for HBV DNA.Similarly,they were 50%,90%,and 72% for HBV RNA/DNA, and 100%, 40%, and 67% for HBcrAg. Conclusion : Our findings confirm that HBV DNA is useful for identifying patients who are at high risk for HBV breakthrough.HBcrAg is useful for isolating those who are at low risk, and HBV RNA/DNA showed predictive characteristics similar to HBV DNA with higher sensitivity and the highest accuracy | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 0037-3826 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AN00120815 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
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MATSUMOTO, Akihiro, MAKI, Noboru, YOSHIZAWA, Kaname, UMEMURA, Takeji, JOSHITA, Satoru, TANAKA, Eiji, 2010, Comparison of Hepatitis B Virus DNA, RNA, and Core Related Antigen as Predictors of Lamivudine Resistance in Patients with Chronic Hepatitis B: 信州医学会, 153–162 p.
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