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Irradiation Stimulates Human Lung Fibroblasts to Release Inflammatory Cell Chemotactic Activity
http://hdl.handle.net/10091/10060
http://hdl.handle.net/10091/100603627b295-1968-4636-a0a0-b58f3f84b804
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-04-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Irradiation Stimulates Human Lung Fibroblasts to Release Inflammatory Cell Chemotactic Activity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | irradiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | human lung fibroblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chemotaxis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-8 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MCP-1 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
KURAI, Makoto
× KURAI, Makoto× KOYAMA, Sekiya |
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出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌. 58(2): 57-68 (2010) | |||||
書誌情報 |
信州医学雑誌 巻 58, 号 2, p. 57-68, 発行日 2010-04-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background :Radiation therapy plays an important role in the treatment of lung cancer. However, it also radiation therapy often induces serious complications such as radiation-induced pneumonitis and its underlying mechanism remains to be elucidated. Objectives :The present study examined whether radiation might stimulate human lung fibroblasts (HLF)to release neutrophil and monocyte chemotactic activity (NCA and MCA). Methods :HLF were exposed to varying doses of radiation (3-12 Gy)at varying incubation times (12-72 hr). The chemotaxis assays of NCA and MCA were performed by a 48-well microchemotaxis chamber method. The effect of polyclonal antibodies of various cytokines on NCA and MCA was evaluated.Furthermore, the protein and mRNA expression of these effective cytokines was assessed by ELISA and RT-PCR. Results :HLF released NCA and MCA in response to irradiation in a dose-and time-dependent manner. NCA was significantly inhibited by anti-interleukin (IL)-8 antibody and MCA was significantly attenuated by antimonocyte chemoattractant protein (MCP)-1 antibody. The protein secretion of IL-8 and MCP-1 was significantly increased by irradiation, and mRNA expression of IL-8 and MCP-1 was upregulated by irradiation. Conclusion :These findings suggest that HLF may,at least partly,participate in the development of radiationinduced pneumonitis. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11441/shinshumedj.58.57 | |||||
関連名称 | 10.11441/shinshumedj.58.57 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |