{"_buckets": {"deposit": "c6abf69a-0425-420d-b1a5-e4b802d2e6e4"}, "_deposit": {"id": "4188", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4188"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004188", "sets": []}, "author_link": ["9528", "9529", "9530", "9531", "9532", "9533"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-12-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "253", "bibliographicPageStart": "247", "bibliographicVolumeNumber": "57", "bibliographic_titles": [{"bibliographic_title": "\u4fe1\u5dde\u533b\u5b66\u96d1\u8a8c"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background : No single agent or combination therapy for advanced pancreatic cancer has been reported superior to single-agent GEM, and an effective second-line chemotherapy  option is needed for patients who are resistant to first-line GEM therapy. Methods :We analyzed six patients who had disease progression following first-line gemcitabine therapy. Patients received second-line chemotherapy with low dose cisplatin, 5-fluorouracul or S-1,and gemcitabine every 21 days. Results : Two patients showed a partial response (33.3%) and two showed stable disease. Four patients (66.6%) showed a prolonged survival time with partial responses or stable disease.Median survival times were 7 and 11 months from the start of second-line therapy and the start of first-line gemcitabine therapy,respectively. In addition, all patients reported relief from pain and had a favorable performance status. The major toxicities of leucopenia, stomatitis, and diarrhea were found in one patient each.Conclusion : This second-line chemotherapy regimen is an effective option for patients with gemcitabineresistant pancreatic cancer.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "\u4fe1\u5dde\u533b\u5b66\u96d1\u8a8c 57(6): 247-253(2009)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": 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[{"nameIdentifier": "9529", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OCHI, Yasuhide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9530", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HAMANO, Hideaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9531", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANAKA, Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9532", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAWA, Shigeyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9533", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Shinshu_Med57-6-03.pdf", "filesize": [{"value": "929.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 929200.0, "url": {"label": "Shinshu_Med57-6-03.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4188/files/Shinshu_Med57-6-03.pdf"}, "version_id": "9fd8aa57-38f4-4ca2-bb9e-dab4a2e24e1e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "second-lin chemotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pancreatic cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "5-FU", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cisplatin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Gemcitabine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Combination Chemotherapy with Low-dose 5-FU, Cisplatin, and Gemcitabine for Gemcitabine-Refractory Pancreatic Cancer", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Combination Chemotherapy with Low-dose 5-FU, Cisplatin, and Gemcitabine for Gemcitabine-Refractory Pancreatic Cancer", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/463/464/499"], "permalink_uri": "http://hdl.handle.net/10091/3729", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-12-15"}, "publish_date": "2009-12-15", "publish_status": "0", "recid": "4188", "relation": {}, "relation_version_is_last": true, "title": ["Combination Chemotherapy with Low-dose 5-FU, Cisplatin, and Gemcitabine for Gemcitabine-Refractory Pancreatic Cancer"], "weko_shared_id": -1}