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  1. 050 医学部, 大学院医学系研究科
  2. 0502 紀要・刊行物
  3. 05021 信州医学雑誌
  4. Vol. 51 No. 1

Calcineurin inhibitor投与法に苦慮した生体腎移植の1例 :ミコフェノール酸モフェチル併用の有用性

http://hdl.handle.net/10091/9329
2cfe1b97-f5cd-4a42-b626-9be5acd6206d
名前 / ファイル ライセンス アクション
Shinshu_Med51-1-05.pdf Shinshu_Med51-1-05.pdf (342.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-03-24
タイトル
タイトル Calcineurin inhibitor投与法に苦慮した生体腎移植の1例 :ミコフェノール酸モフェチル併用の有用性
言語
言語 jpn
キーワード
主題Scheme Other
主題 tacrolimus
キーワード
主題Scheme Other
主題 cyclosporin A
キーワード
主題Scheme Other
主題 mycophenolate mofetil
キーワード
主題Scheme Other
主題 drug-induced nephropathy
キーワード
主題Scheme Other
主題 hyperglycemia
キーワード
主題Scheme Other
主題 タクロリムス
キーワード
主題Scheme Other
主題 サイクロスポリンA
キーワード
主題Scheme Other
主題 ミコフェノール酸モフェチル
キーワード
主題Scheme Other
主題 薬剤性腎障害
キーワード
主題Scheme Other
主題 高血糖
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
その他(別言語等)のタイトル
その他のタイトル A Case Report of Living-Related Renal Transplantation Accompanied by Complications Induced by Calcineurin Inhibitors
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出版者
出版者 信州医学会
引用
内容記述タイプ Other
内容記述 信州医学雑誌 51(1): 25-29(2003)
書誌情報 信州医学雑誌

巻 51, 号 1, p. 25-29, 発行日 2003-02
抄録
内容記述タイプ Abstract
内容記述 A 19-year-old woman received an ABO-compatible living-related renal transplant whose donor was her 46-year-old mother (HLA A, B 2 match, DR 2 match), on December 9, 1999. The etiology of the patient's native kidney disease was diagnosed as chronic glomerulonephritis (sclerosing glomerulonephritis) based on renal biopsy. The induction therapy included tacrolimus(FK) and prednisolone. The first graft biopsy on the 27th postoperative day revealed FK-associated nephropathy(microangiopathy) because of unstable blood FK. After lowering FK blood concentration, the serum creatinine (SCr) level soon decreased from 1.2mg/dl to 0.7mg/dl.On the 40th postoperative day she developed hyperglycemia,which improved soon after the conversion of tacrolimus to cyclosporin A (CsA). The blood CsA trough level was maintained at about 100ng/ml; however, the SCr level increased up to 0.97mg/dl in May 2000. A second graft biopsy was carried out, which revealed no sign of CsA-associated nephropathy, rejection, or nephritis. However, the SCr level increased gradually to 1.2mg/dl.We therefore suspected CsA-associated functional nephropathy and gradually lowered the CsA trough level to 50ng/ml while administering mycophenolate mofetil(MMF)(2g/day). After September 2000 the SCr level was maintained between 0.7 and 0.8mg/dl. We should reconsider the past protocol for livingrelated renal transplantation based on calcineurin inhibitors and steroids.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0037-3826
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00120815
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