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Calcineurin inhibitor投与法に苦慮した生体腎移植の１例 :ミコフェノール酸モフェチル併用の有用性
http://hdl.handle.net/10091/9329
http://hdl.handle.net/10091/93292cfe1b97-f5cd-4a42-b626-9be5acd6206d
| 名前 / ファイル | ライセンス | アクション |
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Shinshu_Med51-1-05.pdf (342.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2010-03-24 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Calcineurin inhibitor投与法に苦慮した生体腎移植の１例 :ミコフェノール酸モフェチル併用の有用性 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | A Case Report of Living-Related Renal Transplantation Accompanied by Complications Induced by Calcineurin Inhibitors | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | jpn | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | tacrolimus, cyclosporin A, mycophenolate mofetil, drug-induced nephropathy, hyperglycemia タクロリムス, サイクロスポリンＡ, ミコフェノール酸モフェチル, 薬剤性腎障害, 高血糖 |
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| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
出浦, 正
× 出浦, 正
× 徳永, 真一
× 重松, 秀一
× 樋口, 誠
× 清澤, 研道
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| 出版者 | ||||||||||||||||
| 出版者 | 信州医学会 | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | 信州医学雑誌 51(1): 25-29(2003) | |||||||||||||||
| 書誌情報 |
信州医学雑誌 巻 51, 号 1, p. 25-29, 発行日 2003-02 |
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| 抄録 | ||||||||||||||||
| 内容記述 | A 19-year-old woman received an ABO-compatible living-related renal transplant whose donor was her 46-year-old mother (HLA A, B 2 match, DR 2 match), on December 9, 1999. The etiology of the patient's native kidney disease was diagnosed as chronic glomerulonephritis (sclerosing glomerulonephritis) based on renal biopsy. The induction therapy included tacrolimus(FK) and prednisolone. The first graft biopsy on the 27th postoperative day revealed FK-associated nephropathy(microangiopathy) because of unstable blood FK. After lowering FK blood concentration, the serum creatinine (SCr) level soon decreased from 1.2mg/dl to 0.7mg/dl.On the 40th postoperative day she developed hyperglycemia,which improved soon after the conversion of tacrolimus to cyclosporin A (CsA). The blood CsA trough level was maintained at about 100ng/ml; however, the SCr level increased up to 0.97mg/dl in May 2000. A second graft biopsy was carried out, which revealed no sign of CsA-associated nephropathy, rejection, or nephritis. However, the SCr level increased gradually to 1.2mg/dl.We therefore suspected CsA-associated functional nephropathy and gradually lowered the CsA trough level to 50ng/ml while administering mycophenolate mofetil(MMF)(2g/day). After September 2000 the SCr level was maintained between 0.7 and 0.8mg/dl. We should reconsider the past protocol for livingrelated renal transplantation based on calcineurin inhibitors and steroids. | |||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0037-3826 | |||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AN00120815 | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
