ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "7be565b5-6715-4415-a32c-d2a0415e15ef"}, "_deposit": {"id": "6918", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6918"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00006918", "sets": []}, "author_link": ["16762", "16763", "16764", "16765", "16766"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-02-29", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "138", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "紀要"}]}]}, "item_10_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The antigenic determinants of thyroglobulin (Tg) using the amount of antibodies produced in cultured human lymphocytes from peripheral blood by the stimulation of either native Tg or 8 kinds of the synthetic peptides from Tg were examined in this study. The serums or lymphocytes from the peripheral blood were obtained from 2 patients with chronic thyroiditis, 2 patients with Graves\u0027 disease and 2 normal controls. The 10⁶ of lymphocytes per each well in the microplate were cultured with 1μg/ml Tg or synthetic peptides for 3 to 6 days. Thereafter, the amount of antibodies in the supernatants were measured by enzyme-linked immunosorbent assay in the wells bound by either Tg or synthetic peptides prior. In 1 case of chronic thyroiditis, significant titer of antibodies against Tg or 2 kinds of synthetic peptides were observed, whereas nomal control and cultivation with medium alone never showed the productions of antibodies. The reactions between synthetic peptides and autoantibodies in the serum from patients with both chronic thyroiditis or Graves\u0027s disease were also observed. Our results suggested that the 2 kinds of synthetic peptides might reflect the activating determinants related to producing the autoantibodies, and molecular mimicry of antigen might be associated with the mechanism of yielding the autoantibodies in this portion.", "subitem_description_type": "Abstract"}]}, "item_10_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_10_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "紀要 21: 133-138(1996)", "subitem_description_type": "Other"}]}, "item_10_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学医療技術短期大学部"}]}, "item_10_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-1982", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-1982", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN10402438", "subitem_source_identifier_type": "NCID"}]}, "item_10_text_66": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "14"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "加藤,  亮二", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸山,  正幸", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16763", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "亀子,  文子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高宮,  脩", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16765", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菅谷,  昭", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16766", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Allied_Med21_14.pdf", "filesize": [{"value": "306.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 306100.0, "url": {"label": "Allied_Med21_14.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/6918/files/Allied_Med21_14.pdf"}, "version_id": "73b4b95f-8978-439b-82dd-f5d01415a05d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Synthetic Peptide", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lymphocyte from Peripheral Blood", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Thyroglobulin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B Cell Response", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T Cell Response", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "合成ペプチド", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "末梢血リンパ球", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイログロプリン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B細胞応答", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T細胞応答", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究", "subitem_title_language": "ja"}, {"subitem_title": "Studies of Antigenic Determinants on Human Thyroglobulin using Synthetic Peptides", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["812"], "permalink_uri": "http://hdl.handle.net/10091/5200", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-03-01"}, "publish_date": "2010-03-01", "publish_status": "0", "recid": "6918", "relation": {}, "relation_version_is_last": true, "title": ["合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0502 紀要・刊行物
  3. 05022 医療技術短期大学部紀要
  4. Vol. 21

合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究

http://hdl.handle.net/10091/5200
http://hdl.handle.net/10091/5200
c7d94933-fcac-48b7-afe9-70f7ec5aeaa6
名前 / ファイル ライセンス アクション
Allied_Med21_14.pdf Allied_Med21_14.pdf (306.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-03-01
タイトル
言語 ja
タイトル 合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究
タイトル
言語 en
タイトル Studies of Antigenic Determinants on Human Thyroglobulin using Synthetic Peptides
言語
言語 jpn
キーワード
言語 en
主題Scheme Other
主題 Synthetic Peptide
キーワード
言語 en
主題Scheme Other
主題 Lymphocyte from Peripheral Blood
キーワード
言語 en
主題Scheme Other
主題 Thyroglobulin
キーワード
言語 en
主題Scheme Other
主題 B Cell Response
キーワード
言語 en
主題Scheme Other
主題 T Cell Response
キーワード
言語 ja
主題Scheme Other
主題 合成ペプチド
キーワード
言語 ja
主題Scheme Other
主題 末梢血リンパ球
キーワード
言語 ja
主題Scheme Other
主題 サイログロプリン
キーワード
言語 ja
主題Scheme Other
主題 B細胞応答
キーワード
言語 ja
主題Scheme Other
主題 T細胞応答
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 加藤, 亮二

× 加藤, 亮二

WEKO 16762

ja 加藤, 亮二

Search repository
丸山, 正幸

× 丸山, 正幸

WEKO 16763

ja 丸山, 正幸

Search repository
亀子, 文子

× 亀子, 文子

WEKO 16764

ja 亀子, 文子

Search repository
高宮, 脩

× 高宮, 脩

WEKO 16765

ja 高宮, 脩

Search repository
菅谷, 昭

× 菅谷, 昭

WEKO 16766

ja 菅谷, 昭

Search repository
出版者
出版者 信州大学医療技術短期大学部
引用
内容記述タイプ Other
内容記述 紀要 21: 133-138(1996)
書誌情報 紀要

巻 21, p. 133-138, 発行日 1996-02-29
抄録
内容記述タイプ Abstract
内容記述 The antigenic determinants of thyroglobulin (Tg) using the amount of antibodies produced in cultured human lymphocytes from peripheral blood by the stimulation of either native Tg or 8 kinds of the synthetic peptides from Tg were examined in this study. The serums or lymphocytes from the peripheral blood were obtained from 2 patients with chronic thyroiditis, 2 patients with Graves' disease and 2 normal controls. The 10⁶ of lymphocytes per each well in the microplate were cultured with 1μg/ml Tg or synthetic peptides for 3 to 6 days. Thereafter, the amount of antibodies in the supernatants were measured by enzyme-linked immunosorbent assay in the wells bound by either Tg or synthetic peptides prior. In 1 case of chronic thyroiditis, significant titer of antibodies against Tg or 2 kinds of synthetic peptides were observed, whereas nomal control and cultivation with medium alone never showed the productions of antibodies. The reactions between synthetic peptides and autoantibodies in the serum from patients with both chronic thyroiditis or Graves's disease were also observed. Our results suggested that the 2 kinds of synthetic peptides might reflect the activating determinants related to producing the autoantibodies, and molecular mimicry of antigen might be associated with the mechanism of yielding the autoantibodies in this portion.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0385-1982
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN10402438
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 13:10:44.390513
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3