{"_buckets": {"deposit": "7be565b5-6715-4415-a32c-d2a0415e15ef"}, "_deposit": {"id": "6918", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6918"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00006918", "sets": []}, "author_link": ["16762", "16763", "16764", "16765", "16766"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-02-29", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "138", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "紀要"}]}]}, "item_10_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The antigenic determinants of thyroglobulin (Tg) using the amount of antibodies produced in cultured human lymphocytes from peripheral blood by the stimulation of either native Tg or 8 kinds of the synthetic peptides from Tg were examined in this study. The serums or lymphocytes from the peripheral blood were obtained from 2 patients with chronic thyroiditis, 2 patients with Graves\u0027 disease and 2 normal controls. The 10⁶ of lymphocytes per each well in the microplate were cultured　with 1μg/ml Tg or synthetic peptides for 3 to 6 days. Thereafter, the amount of antibodies in the supernatants were measured by enzyme-linked immunosorbent assay in the wells bound by either Tg or synthetic peptides prior. In 1 case of chronic thyroiditis, significant titer of antibodies against Tg or 2 kinds of synthetic peptides were observed, whereas nomal control and cultivation with medium alone never showed the productions of antibodies. The reactions between synthetic peptides and autoantibodies in the serum from patients with both chronic thyroiditis or Graves\u0027s disease were also observed. Our results suggested that the 2 kinds of synthetic peptides might reflect the activating determinants related to producing the autoantibodies, and molecular mimicry of antigen might be associated with the mechanism of yielding the autoantibodies in this portion.", "subitem_description_type": "Abstract"}]}, "item_10_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_10_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "紀要 21: 133-138(1996)", "subitem_description_type": "Other"}]}, "item_10_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学医療技術短期大学部"}]}, "item_10_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-1982", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-1982", "subitem_source_identifier_type": "ISSN"}]}, "item_10_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN10402438", "subitem_source_identifier_type": "NCID"}]}, "item_10_text_66": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "14"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "加藤,  亮二", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸山,  正幸", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16763", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "亀子,  文子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高宮,  脩", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16765", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菅谷,  昭", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "16766", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Allied_Med21_14.pdf", "filesize": [{"value": "306.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 306100.0, "url": {"label": "Allied_Med21_14.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/6918/files/Allied_Med21_14.pdf"}, "version_id": "73b4b95f-8978-439b-82dd-f5d01415a05d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Synthetic Peptide", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lymphocyte from Peripheral Blood", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Thyroglobulin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B Cell Response", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T Cell Response", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "合成ペプチド", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "末梢血リンパ球", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイログロプリン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B細胞応答", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T細胞応答", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究", "subitem_title_language": "ja"}, {"subitem_title": "Studies of Antigenic Determinants on Human Thyroglobulin using Synthetic Peptides", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["812"], "permalink_uri": "http://hdl.handle.net/10091/5200", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-03-01"}, "publish_date": "2010-03-01", "publish_status": "0", "recid": "6918", "relation": {}, "relation_version_is_last": true, "title": ["合成ペプチド抗原を使用したヒトサイログロブリンエピトープの研究"], "weko_shared_id": -1}