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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Distinct Cytoplasmic Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma: A Comparative Immunohistochemical Study with Other Renal Epithelial Cell Tumors

http://hdl.handle.net/10091/17666
f73963b0-ca1f-4806-a6b0-cda64add0e5d
名前 / ファイル ライセンス アクション
H24Otsu1152_Fukushima.pdf H24Otsu1152_Fukushima.pdf (2.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-27
タイトル
言語 en
タイトル Distinct Cytoplasmic Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma: A Comparative Immunohistochemical Study with Other Renal Epithelial Cell Tumors
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Fukushima, Mana

× Fukushima, Mana

WEKO 17342

Fukushima, Mana

Search repository
Higuchi, Kayoko

× Higuchi, Kayoko

WEKO 17343

Higuchi, Kayoko

Search repository
Shimojo, Hisashi

× Shimojo, Hisashi

WEKO 17344

Shimojo, Hisashi

Search repository
Uehara, Takeshi

× Uehara, Takeshi

WEKO 17345

Uehara, Takeshi

Search repository
Ota, Hiroyoshi

× Ota, Hiroyoshi

WEKO 17346

Ota, Hiroyoshi

Search repository
出版者
出版者 JAPAN SOC HISTOCHEM CYTOCHEM
引用
内容記述タイプ Other
内容記述 ACTA HISTOCHEMICA ET CYTOCHEMICA. 45(5) 301-308 (2012)
書誌情報 ACTA HISTOCHEMICA ET CYTOCHEMICA

巻 45, 号 5, p. 301-308, 発行日 2012
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成25年1月30日授与(乙第1152号)・福島 万奈
抄録
内容記述タイプ Abstract
内容記述 The presence of cytoplasmic sialyl glycoproteins is a conspicuous feature in chromophobe renal cell carcinoma (RCC). We compared the immunohistochemical expression of sialyl glycoproteins in chromophobe RCC with that in other types of renal tumors. Formalin-fixed, paraffin-embedded tissues of surgically resected renal tumors (chromophobe RCC, 14 cases [10 cases of classic type and 4 cases of eosinophilic variant]; oncocytoma, 7 cases; and clear cell RCC, 9 cases) and kidneys from immature infants (4 cases) were immunostained with antibodies against sialyl glycoproteins (anti-KL-6 and anti-sialyl MUC1 antibodies). Cytoplasmic expression of KL-6 and sialyl MUC1 was distinctive in the chromophobe RCC and renal oncocytoma cells, and in the intercalated cells in collecting duct epithelia. Apical-surface staining of these sialyl glycoproteins was predominantly observed in clear RCC, in the epithelia of the distal tubule and collecting duct, and in the neonatal renal proximal tubule, but not in those of the adult renal proximal tubule. The above-mentioned observations provide additional evidence for similar phenotypic profiles of chromophobe RCC and renal oncocytoma, and the intercalated cells in collecting ducts and the oncofetal expression of sialyl glycoproteins in clear cell RCC. KL-6 is a potential tumor marker for renal tumors.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1267/ahc.12020
関連名称
関連名称 10.1267/ahc.12020
権利
権利情報 Copyright (c) 2012 By the Japan Society of Histochemistry and Cytochemistry
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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