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Distinct Cytoplasmic Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma: A Comparative Immunohistochemical Study with Other Renal Epithelial Cell Tumors
http://hdl.handle.net/10091/17666
http://hdl.handle.net/10091/17666f73963b0-ca1f-4806-a6b0-cda64add0e5d
名前 / ファイル | ライセンス | アクション |
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H24Otsu1152_Fukushima.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Distinct Cytoplasmic Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma: A Comparative Immunohistochemical Study with Other Renal Epithelial Cell Tumors | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1267/ahc.12020 | |||||
関連名称 | 10.1267/ahc.12020 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Fukushima, Mana
× Fukushima, Mana× Higuchi, Kayoko× Shimojo, Hisashi× Uehara, Takeshi× Ota, Hiroyoshi |
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出版者 | ||||||
出版者 | JAPAN SOC HISTOCHEM CYTOCHEM | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ACTA HISTOCHEMICA ET CYTOCHEMICA. 45(5) 301-308 (2012) | |||||
書誌情報 |
ACTA HISTOCHEMICA ET CYTOCHEMICA 巻 45, 号 5, p. 301-308, 発行日 2012 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州大学博士(医学)・学位論文・平成25年1月30日授与(乙第1152号)・福島 万奈 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The presence of cytoplasmic sialyl glycoproteins is a conspicuous feature in chromophobe renal cell carcinoma (RCC). We compared the immunohistochemical expression of sialyl glycoproteins in chromophobe RCC with that in other types of renal tumors. Formalin-fixed, paraffin-embedded tissues of surgically resected renal tumors (chromophobe RCC, 14 cases [10 cases of classic type and 4 cases of eosinophilic variant]; oncocytoma, 7 cases; and clear cell RCC, 9 cases) and kidneys from immature infants (4 cases) were immunostained with antibodies against sialyl glycoproteins (anti-KL-6 and anti-sialyl MUC1 antibodies). Cytoplasmic expression of KL-6 and sialyl MUC1 was distinctive in the chromophobe RCC and renal oncocytoma cells, and in the intercalated cells in collecting duct epithelia. Apical-surface staining of these sialyl glycoproteins was predominantly observed in clear RCC, in the epithelia of the distal tubule and collecting duct, and in the neonatal renal proximal tubule, but not in those of the adult renal proximal tubule. The above-mentioned observations provide additional evidence for similar phenotypic profiles of chromophobe RCC and renal oncocytoma, and the intercalated cells in collecting ducts and the oncofetal expression of sialyl glycoproteins in clear cell RCC. KL-6 is a potential tumor marker for renal tumors. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
権利 | ||||||
権利情報 | Copyright (c) 2012 By the Japan Society of Histochemistry and Cytochemistry | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |