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Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis
http://hdl.handle.net/10091/17668
http://hdl.handle.net/10091/17668bd3fd45b-a252-4602-b1d0-3c57ab9d257a
| 名前 / ファイル | ライセンス | アクション |
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H24Kou946_Maruyama.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2014-06-27 | |||||||||||||||||||||||
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| タイトル | Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1097/MPA.0b013e318258ce4c | |||||||||||||||||||||||
| 関連名称 | 10.1097/MPA.0b013e318258ce4c | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Maruyama, Masafumi
× Maruyama, Masafumi
× Kobayashi, Motohiro
× Sakai, Yasuhiro
× Hiraoka, Nobuyoshi
× Ohya, Ayumi
× Kageyama, Shunsuke
× Tanaka, Eiji
× Nakayama, Jun
× Morohoshi, Toshio
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | PANCREAS. 42(1):53-59 (2013) | |||||||||||||||||||||||
| 書誌情報 |
PANCREAS 巻 42, 号 1, p. 53-59, 発行日 2013-01 |
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | 信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第946号）・丸山 雅史 | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | This is a non-final version of an article published in final form in PANCREAS. 42(1):53-59 (2013). | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Objectives: Type 1 autoimmune pancreatitis (AIP) is histologically characterized by dense lymphoplasmacytic infiltration and marked storiform fibrosis, manifestations associated with pancreatic ducts. Such periductal lymphocyte recruitment is thought to be elicited by dysregulation of mechanisms governing physiological lymphocyte homing. The present study was undertaken to determine whether vascular addressins including peripheral lymph node addressin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) play a role in type 1 AIP histogenesis. Methods: Tissue sections of type 1 AIP and tumor-associated non-AIP chronic pancreatitis, as well as normal pancreas, were subjected to immunohistochemical analysis using vascular addressin-related antibodies. Results: The number of periductal mouse endothelial cell antigen 79-positive high endothelial venule (HEV)-like vessels was increased in type 1 AIP relative to that seen in non-AIP chronic pancreatitis, whereas the number of MAdCAM-1-positive HEV-like vessels did not differ between the 2 conditions. Mouse endothelial cell antigen 79 antigens are expressed on duct-forming epithelial cells not only in pancreas but also in salivary glands, which often harbor extrapancreatic lesions in type 1 AIP. Conclusions: Type 1 AIP can be characterized by periductal induction of MECA-79-positive HEV-like vessels. MECA-79-positive 6-sulfo sialyl Lewis X-related carbohydrate antigens expressed on duct-forming epithelial cells could be associated with type 1 AIP pathogenesis. | |||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
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Maruyama, Masafumi, Kobayashi, Motohiro, Sakai, Yasuhiro, Hiraoka, Nobuyoshi, Ohya, Ayumi, Kageyama, Shunsuke, Tanaka, Eiji, Nakayama, Jun, Morohoshi, Toshio, 2013, Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis: LIPPINCOTT WILLIAMS & WILKINS, 53–59 p.
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