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  1. 050 医学部, 大学院医学系研究科 (Faculty&Graduate School of Medicine)
  2. 0507 学位論文 (Thesis or Dissertation)
  3. 博士(医学)

Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis

http://hdl.handle.net/10091/17668
bd3fd45b-a252-4602-b1d0-3c57ab9d257a
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H24Kou946_Maruyama.pdf H24Kou946_Maruyama.pdf (1.6 MB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-27
タイトル
タイトル Periductal Induction of High Endothelial Venule-Like Vessels in Type 1 Autoimmune Pancreatitis
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Maruyama, Masafumi

× Maruyama, Masafumi

WEKO 17383

Maruyama, Masafumi

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Kobayashi, Motohiro

× Kobayashi, Motohiro

WEKO 17384

Kobayashi, Motohiro

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Sakai, Yasuhiro

× Sakai, Yasuhiro

WEKO 17385

Sakai, Yasuhiro

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Hiraoka, Nobuyoshi

× Hiraoka, Nobuyoshi

WEKO 17386

Hiraoka, Nobuyoshi

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Ohya, Ayumi

× Ohya, Ayumi

WEKO 17387

Ohya, Ayumi

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Kageyama, Shunsuke

× Kageyama, Shunsuke

WEKO 17388

Kageyama, Shunsuke

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Tanaka, Eiji

× Tanaka, Eiji

WEKO 17389

Tanaka, Eiji

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Nakayama, Jun

× Nakayama, Jun

WEKO 17390

Nakayama, Jun

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Morohoshi, Toshio

× Morohoshi, Toshio

WEKO 17391

Morohoshi, Toshio

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出版者
出版者 LIPPINCOTT WILLIAMS & WILKINS
引用
内容記述タイプ Other
内容記述 PANCREAS. 42(1):53-59 (2013)
書誌情報 PANCREAS

巻 42, 号 1, p. 53-59, 発行日 2013-01
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第946号)・丸山 雅史
内容記述
内容記述タイプ Other
内容記述 This is a non-final version of an article published in final form in PANCREAS. 42(1):53-59 (2013).
抄録
内容記述タイプ Abstract
内容記述 Objectives: Type 1 autoimmune pancreatitis (AIP) is histologically characterized by dense lymphoplasmacytic infiltration and marked storiform fibrosis, manifestations associated with pancreatic ducts. Such periductal lymphocyte recruitment is thought to be elicited by dysregulation of mechanisms governing physiological lymphocyte homing. The present study was undertaken to determine whether vascular addressins including peripheral lymph node addressin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) play a role in type 1 AIP histogenesis. Methods: Tissue sections of type 1 AIP and tumor-associated non-AIP chronic pancreatitis, as well as normal pancreas, were subjected to immunohistochemical analysis using vascular addressin-related antibodies. Results: The number of periductal mouse endothelial cell antigen 79-positive high endothelial venule (HEV)-like vessels was increased in type 1 AIP relative to that seen in non-AIP chronic pancreatitis, whereas the number of MAdCAM-1-positive HEV-like vessels did not differ between the 2 conditions. Mouse endothelial cell antigen 79 antigens are expressed on duct-forming epithelial cells not only in pancreas but also in salivary glands, which often harbor extrapancreatic lesions in type 1 AIP. Conclusions: Type 1 AIP can be characterized by periductal induction of MECA-79-positive HEV-like vessels. MECA-79-positive 6-sulfo sialyl Lewis X-related carbohydrate antigens expressed on duct-forming epithelial cells could be associated with type 1 AIP pathogenesis.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1097/MPA.0b013e318258ce4c
関連名称
関連名称 10.1097/MPA.0b013e318258ce4c
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