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Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress
http://hdl.handle.net/10091/16027
http://hdl.handle.net/10091/160277eeecd47-6bbb-4a17-8aed-801204df3643
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
H23Kou921_Sheng.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-10-03 | |||||
| タイトル | ||||||
| タイトル | Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1620/tjem.227.1 | |||||
| 関連名称 | 10.1620/tjem.227.1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebroside sulfotransferase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | clofibrate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | kidney injury | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxidative stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sulfatides | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sheng, Xiaona
× Sheng, Xiaona× Nakajima, Takero× Wang, Lixuan× Zhang, Xiaowei× Kamijo, Yuji× Takahashi, Kyoko× Tanaka, Naoki× Sugiyama, Eiko× Kyogashima, Mamoru× Aoyama, Toshifumi× Hara, Atsushi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nakajima, Takero | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kamijo, Yuji | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html | |||||
| 出版者 | ||||||
| 出版者 | TOHOKU UNIV MEDICAL PRESS | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE. 227(1):1-12 (2012) | |||||
| 書誌情報 |
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 巻 227, 号 1, p. 1-12, 発行日 2012-05 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第921号）・生暁娜 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Serum sulfatides are the major glycosphingolipids in lipoproteins. Although serum sulfatides are mainly synthesized and secreted by the liver, they are significantly decreased when the kidneys are impaired. Our recent experimental study using a murine protein-overload nephropathy model suggested a hypothetical mechanism whereby serum sulfatides were reduced due to kidney dysfunction. This was the result of decreased hepatic expression of a sulfatide synthetic enzyme, cerebroside sulfotransferase (CST), which is associated with systemic enhancement of oxidative stress. However, there is a possibility that the experimental process, protein-overload itself, directly affected the sulfatide metabolism and oxidative stress in the liver. To determine whether kidney dysfunction actually reduces the hepatic synthesis of sulfatides via oxidative stress, we examined sulfatide levels, the hepatic content of metabolic sulfatide enzymes, and the degree of oxidative stress in protein-overload mice subjected to renoprotective therapy using clofibrate, a representative hypolipidemic medicine. Protein-overload mice exhibited marked kidney injuries, enhancement of hepatic oxidative stress, decreased levels of serum and hepatic sulfatides, and decreased expression of hepatic CST. The clofibrate treatment attenuated kidney damage and hepatic oxidative stress while maintaining serum/hepatic sulfatide levels and hepatic CST content in the mice. Because clofibrate monotherapy without protein-overload treatment only minimally affected these hepatic parameters, the hepatic synthesis of sulfatides appeared to be strongly influenced by kidney dysfunction and subsequent oxidative stress. This study suggests that the crosstalk between kidney dysfunction and hepatic sulfatide metabolism is mediated by oxidative stress. These results should help to understand the phenomenon in patients with end-stage kidney disease. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0040-8727 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00863920 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22499158 | |||||
| 関連名称 | 22499158 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000304569500001 | |||||
