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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Essential role of gastric gland mucin in preventing gastric cancer in mice

http://hdl.handle.net/10091/16026
061efb51-e2e3-4e3c-94eb-3e4a53538c5a
名前 / ファイル ライセンス アクション
H23Kou916_karasawa.pdf H23Kou916_karasawa.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-10-02
タイトル
言語 en
タイトル Essential role of gastric gland mucin in preventing gastric cancer in mice
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Karasawa, Fumitoshi

× Karasawa, Fumitoshi

WEKO 17428

Karasawa, Fumitoshi

Search repository
Shiota, Akira

× Shiota, Akira

WEKO 17429

Shiota, Akira

Search repository
Goso, Yukinobu

× Goso, Yukinobu

WEKO 17430

Goso, Yukinobu

Search repository
Kobayashi, Motohiro

× Kobayashi, Motohiro

WEKO 17431

Kobayashi, Motohiro

Search repository
Sato, Yoshiko

× Sato, Yoshiko

WEKO 17432

Sato, Yoshiko

Search repository
Masumoto, Junya

× Masumoto, Junya

WEKO 17433

Masumoto, Junya

Search repository
Fujiwara, Maiko

× Fujiwara, Maiko

WEKO 17434

Fujiwara, Maiko

Search repository
Yokosawa, Shuichi

× Yokosawa, Shuichi

WEKO 17435

Yokosawa, Shuichi

Search repository
Muraki, Takashi

× Muraki, Takashi

WEKO 17436

Muraki, Takashi

Search repository
Miyagawa, Shinichi

× Miyagawa, Shinichi

WEKO 17437

Miyagawa, Shinichi

Search repository
Ueda, Masatsugu

× Ueda, Masatsugu

WEKO 17438

Ueda, Masatsugu

Search repository
Fukuda, Michiko N.

× Fukuda, Michiko N.

WEKO 17439

Fukuda, Michiko N.

Search repository
Fukuda, Minoru

× Fukuda, Minoru

WEKO 17440

Fukuda, Minoru

Search repository
Ishihara, Kazuhiko

× Ishihara, Kazuhiko

WEKO 17441

Ishihara, Kazuhiko

Search repository
Nakayama, Jun

× Nakayama, Jun

WEKO 17442

Nakayama, Jun

Search repository
信州大学研究者総覧へのリンク
氏名 Nakayama, Jun
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html
出版者
出版者 AMER SOC CLINICAL INVESTIGATION INC
引用
内容記述タイプ Other
内容記述 JOURNAL OF CLINICAL INVESTIGATION. 122(3):923-934 (2012)
書誌情報 JOURNAL OF CLINICAL INVESTIGATION

巻 122, 号 3, p. 923-934, 発行日 2012-03
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第916号)・唐澤文寿
抄録
内容記述タイプ Abstract
内容記述 Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc). Previously, we identified human alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT), which is responsible for the O-glycan biosynthesis and characterized alpha GlcNAc function in suppressing Helicobacter pylori in vitro. In the present study, we engineered A4gnt(-/-) mice to better understand its role in vivo. A4gnt(-/-) mice showed complete lack of alpha GlcNAc expression in gastric gland mucin. Surprisingly, all the mutant mice developed gastric adenocarcinoma through a hyperplasia-dysplasia-carcinoma sequence in the absence of H. pylori infection. Microarray and quantitative RT-PCR analysis revealed upregulation of genes encoding inflammatory chemokine ligands, proinflammatory cytokines, and growth factors, such as Ccl2, Il-11, and Hgf in the gastric mucosa of A4gnt(-/-) mice. Further supporting an important role for this O-glycan in cancer progression, we also observed significantly reduced alpha GlcNAc in human gastric adenocarcinoma and adenoma. Our results demonstrate that the absence of alpha GlcNAc triggers gastric tumorigenesis through inflammation-associated pathways in vivo. Thus, alpha GlcNAc-terminated gastric mucin plays dual roles in preventing gastric cancer by inhibiting H. pylori infection and also suppressing tumor-promoting inflammation.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0021-9738
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00695520
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22307328
関連名称
関連名称 22307328
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1172/JCI59087
関連名称
関連名称 10.1172/JCI59087
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000301021500018
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