Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2012-10-03 |
タイトル |
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タイトル |
American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1111/j.1447-0594.2011.00719.x |
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関連名称 |
10.1111/j.1447-0594.2011.00719.x |
キーワード |
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主題 |
American ginseng, choline acetyltransferase, insulin; neurocognitive function, senescence-accelerated mouse |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Shi, Shun
Shi, Reika
Hashizume, Kiyoshi
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出版者 |
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出版者 |
WILEY-BLACKWELL |
引用 |
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内容記述 |
GERIATRICS & GERONTOLOGY INTERNATIONAL. 12(1):123-130 (2012) |
書誌情報 |
GERIATRICS & GERONTOLOGY INTERNATIONAL
巻 12,
号 1,
p. 123-130,
発行日 2012-01
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内容記述 |
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内容記述 |
信州大学博士(医学)・学位論文・平成23年3月31日授与(甲第905号)・史峻 |
抄録 |
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内容記述 |
Aim: To investigate the effects of American ginseng on neurocognitive function and glucose regulation in senescence-accelerated mice. Methods: Male senescence-resistant inbred strains (SAMR1) and senescence-prone inbred strains (SAMP10) mice were divided into five groups and fed either a control diet or an American ginseng-supplemented diet (1% or 2% g/g) from 6 weeks to 10 months of age. Bodyweight, levels of fasting plasma glucose (FPG) and grading scores were monitored every month and neurocognitive functions were evaluated at 9 months of age with a KUROBOX apparatus using a stress-free positive cue task. Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. Results: American ginseng decreased FPG in SAMR1 mice, but increased FPG in SAMP10 mice. Correct visit ratios were higher in both SAMR1 and SAMP10 strains consuming an American ginseng-supplemented diet. Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. Conclusion: Daily consumption of American ginseng induced an enhancement in neurocognitive function in senescence-accelerated mice, which could be related to the upregulation of insulin and ChAT gene expression in the brain. Geriatr Gerontol Int 2012; 12: 123-130. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1444-1586 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1155729X |
PubMed |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21702872 |
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関連名称 |
21702872 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000298481600019 |