{"_buckets": {"deposit": "3a84fd22-cb72-438e-a13a-5c0438cd79b1"}, "_deposit": {"id": "7200", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7200"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00007200", "sets": ["849"]}, "author_link": ["17507", "17508", "17509"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "130", "bibliographicPageStart": "123", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "GERIATRICS \u0026 GERONTOLOGY INTERNATIONAL"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "信州大学博士（医学）・学位論文・平成23年3月31日授与（甲第905号）・史峻", "subitem_description_type": "Other"}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aim: To investigate the effects of American ginseng on neurocognitive function and glucose regulation in senescence-accelerated mice. Methods: Male senescence-resistant inbred strains (SAMR1) and senescence-prone inbred strains (SAMP10) mice were divided into five groups and fed either a control diet or an American ginseng-supplemented diet (1% or 2% g/g) from 6 weeks to 10 months of age. Bodyweight, levels of fasting plasma glucose (FPG) and grading scores were monitored every month and neurocognitive functions were evaluated at 9 months of age with a KUROBOX apparatus using a stress-free positive cue task. Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. Results: American ginseng decreased FPG in SAMR1 mice, but increased FPG in SAMP10 mice. Correct visit ratios were higher in both SAMR1 and SAMP10 strains consuming an American ginseng-supplemented diet. Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. Conclusion: Daily consumption of American ginseng induced an enhancement in neurocognitive function in senescence-accelerated mice, which could be related to the upregulation of insulin and ChAT gene expression in the brain. Geriatr Gerontol Int 2012; 12: 123-130.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "GERIATRICS \u0026 GERONTOLOGY INTERNATIONAL. 12(1):123-130 (2012)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000298481600019"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "WILEY-BLACKWELL"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21702872"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21702872", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/j.1447-0594.2011.00719.x"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/j.1447-0594.2011.00719.x", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1444-1586", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1444-1586", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1155729X", "subitem_source_identifier_type": "NCID"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shi,  Shun"}], "nameIdentifiers": [{"nameIdentifier": "17507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shi,  Reika"}], "nameIdentifiers": [{"nameIdentifier": "17508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume,  Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "17509", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "H23Kou905_Shi.pdf", "filesize": [{"value": "522.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 522799.99999999994, "url": {"label": "H23Kou905_Shi.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/7200/files/H23Kou905_Shi.pdf"}, "version_id": "e1f4b0e9-d44f-433f-832c-ade7bb92ca44"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "American ginseng", "subitem_subject_scheme": "Other"}, {"subitem_subject": "choline acetyltransferase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin; neurocognitive function", "subitem_subject_scheme": "Other"}, {"subitem_subject": "senescence-accelerated mouse", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/16032", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-10-03"}, "publish_date": "2012-10-03", "publish_status": "0", "recid": "7200", "relation": {}, "relation_version_is_last": true, "title": ["American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression"], "weko_shared_id": -1}