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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression

http://hdl.handle.net/10091/16032
http://hdl.handle.net/10091/16032
1abfa050-d301-496b-8af1-624ae7b9be95
名前 / ファイル ライセンス アクション
H23Kou905_Shi.pdf H23Kou905_Shi.pdf (522.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-10-03
タイトル
言語 en
タイトル American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression
言語
言語 eng
キーワード
主題Scheme Other
主題 American ginseng
キーワード
主題Scheme Other
主題 choline acetyltransferase
キーワード
主題Scheme Other
主題 insulin; neurocognitive function
キーワード
主題Scheme Other
主題 senescence-accelerated mouse
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shi, Shun

× Shi, Shun

WEKO 17507

Shi, Shun

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Shi, Reika

× Shi, Reika

WEKO 17508

Shi, Reika

Search repository
Hashizume, Kiyoshi

× Hashizume, Kiyoshi

WEKO 17509

Hashizume, Kiyoshi

Search repository
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 GERIATRICS & GERONTOLOGY INTERNATIONAL. 12(1):123-130 (2012)
書誌情報 GERIATRICS & GERONTOLOGY INTERNATIONAL

巻 12, 号 1, p. 123-130, 発行日 2012-01
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成23年3月31日授与(甲第905号)・史峻
抄録
内容記述タイプ Abstract
内容記述 Aim: To investigate the effects of American ginseng on neurocognitive function and glucose regulation in senescence-accelerated mice. Methods: Male senescence-resistant inbred strains (SAMR1) and senescence-prone inbred strains (SAMP10) mice were divided into five groups and fed either a control diet or an American ginseng-supplemented diet (1% or 2% g/g) from 6 weeks to 10 months of age. Bodyweight, levels of fasting plasma glucose (FPG) and grading scores were monitored every month and neurocognitive functions were evaluated at 9 months of age with a KUROBOX apparatus using a stress-free positive cue task. Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. Results: American ginseng decreased FPG in SAMR1 mice, but increased FPG in SAMP10 mice. Correct visit ratios were higher in both SAMR1 and SAMP10 strains consuming an American ginseng-supplemented diet. Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. Conclusion: Daily consumption of American ginseng induced an enhancement in neurocognitive function in senescence-accelerated mice, which could be related to the upregulation of insulin and ChAT gene expression in the brain. Geriatr Gerontol Int 2012; 12: 123-130.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1444-1586
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA1155729X
PubMed
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21702872
関連名称 21702872
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1447-0594.2011.00719.x
関連名称 10.1111/j.1447-0594.2011.00719.x
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000298481600019
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