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  1. 055 医学部附属病院
  2. 0551 学術論文

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

http://hdl.handle.net/10091/17717
8f0a4b1b-eed1-4ba0-b3dc-a10fabbb4ba6
名前 / ファイル ライセンス アクション
Myeloid_progenitors_PTPN11_nonRAS_pathwa_gene.pdf Myeloid_progenitors_PTPN11_nonRAS_pathwa_gene.pdf (339.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-14
タイトル
言語 en
タイトル Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia
言語
言語 eng
キーワード
主題Scheme Other
主題 PTPN11
キーワード
主題Scheme Other
主題 SETBP1
キーワード
主題Scheme Other
主題 JAK3
キーワード
主題Scheme Other
主題 6-MP
キーワード
主題Scheme Other
主題 JMML
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Matsuda, K

× Matsuda, K

WEKO 21959

en Matsuda, K

Search repository
Nakazawa, Y

× Nakazawa, Y

WEKO 21960

en Nakazawa, Y

Search repository
Iwashita, C

× Iwashita, C

WEKO 21961

en Iwashita, C

Search repository
Kurata, T

× Kurata, T

WEKO 21962

en Kurata, T

Search repository
Hirabayashi, K

× Hirabayashi, K

WEKO 21963

en Hirabayashi, K

Search repository
Saito, S

× Saito, S

WEKO 21964

en Saito, S

Search repository
Tanaka, M

× Tanaka, M

WEKO 21965

en Tanaka, M

Search repository
Yoshikawa, K

× Yoshikawa, K

WEKO 21966

en Yoshikawa, K

Search repository
Yanagisawa, R

× Yanagisawa, R

WEKO 21967

en Yanagisawa, R

Search repository
Sakashita, K

× Sakashita, K

WEKO 21968

en Sakashita, K

Search repository
Sasaki, S

× Sasaki, S

WEKO 21969

en Sasaki, S

Search repository
Honda, T

× Honda, T

WEKO 21970

en Honda, T

Search repository
Koike, K

× Koike, K

WEKO 21971

en Koike, K

Search repository
信州大学研究者総覧へのリンク
氏名 Nakazawa, Y
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html
信州大学研究者総覧へのリンク
氏名 Honda, T
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.WeDUHFkh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 LEUKEMIA. 28(7):1545-1548 (2014)
書誌情報 LEUKEMIA

巻 28, 号 7, p. 1545-1548, 発行日 2014-07
内容記述
内容記述タイプ Other
内容記述 advance online publication, February 25, 2014
抄録
内容記述タイプ Abstract
内容記述 Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways, inactivation of the NF1 or mutations in PTPN11, NRAS, KRAS and CBL. A whole-exome sequencing study, performed by Sakaguchi et al.,3 has recently demonstrated that in addition to the high frequency of RAS pathway mutations, mutations in SETBP1 and JAK3 are common recurrent secondary events, and that these events may be involved in tumor progression, and are associated with poor clinical outcomes.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0887-6924
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12305962
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24496301
関連名称
関連名称 24496301
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/leu.2014.58
関連名称
関連名称 10.1038/leu.2014.58
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000339705500022
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