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  1. 055 医学部附属病院
  2. 0551 学術論文

Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications

http://hdl.handle.net/10091/17650
http://hdl.handle.net/10091/17650
9167868a-9f46-4402-996f-dd8ed6fdfbfd
名前 / ファイル ライセンス アクション
Mammalian_Models_Duchenne_Muscular_Dystrophy.pdf Mammalian_Models_Duchenne_Muscular_Dystrophy.pdf (2.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-20
タイトル
言語 en
タイトル Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakamura, Akinori

× Nakamura, Akinori

WEKO 22042

en Nakamura, Akinori

Search repository
Takeda, Shin'ichi

× Takeda, Shin'ichi

WEKO 22043

en Takeda, Shin'ichi

Search repository
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011:184393 (2011)
書誌情報 JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

巻 2011, p. 184393, 発行日 2011
抄録
内容記述タイプ Abstract
内容記述 Duchenne muscular dystrophy (DMD) is a devastating X-linked muscle disorder characterized by muscle wasting which is caused by mutations in the DMD gene. The DMD gene encodes the sarcolemmal protein dystrophin, and loss of dystrophin causes muscle degeneration and necrosis. Thus far, therapies for this disorder are unavailable. However, various therapeutic trials based on gene therapy, exon skipping, cell therapy, read through therapy, or pharmaceutical agents have been conducted extensively. In the development of therapy as well as elucidation of pathogenesis in DMD, appropriate animal models are needed. Various animal models of DMD have been identified, and mammalian (murine, canine, and feline) models are indispensable for the examination of the mechanisms of pathogenesis and the development of therapies. Here, we review the pathological features of DMD and therapeutic applications, especially of exon skipping using antisense oligonucleotides and gene therapies using viral vectors in murine and canine models of DMD.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1110-7243
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11698349
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21274260
関連名称 21274260
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2011/184393
関連名称 10.1155/2011/184393
権利
権利情報 Copyright© 2011 Akinori Nakamura and Shin'ichi Takeda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000287882500001
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