{"_buckets": {"deposit": "d09c8906-4eee-4cff-a905-81875cba3e29"}, "_deposit": {"id": "8023", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8023"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00008023", "sets": ["883"]}, "author_link": ["22067", "22068", "22069", "22070", "22071", "22072", "22073", "22074", "22075", "22076", "22077", "22078", "22079"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "727393", "bibliographicVolumeNumber": "2014", "bibliographic_titles": [{"bibliographic_title": "DISEASE MARKERS"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recent genome-wide association studies suggest that genetic factors contribute to primary biliary cirrhosis (PBC) susceptibility. Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. Single nucleotide polymorphisms (SNPs) were genotyped in 395 PBC patients and 458 healthy subjects of Japanese ethnicity and evaluated for associations with PBC susceptibility, anti-nuclear antibody (ANA) status, and anti-mitochondrial antibody (AMA) status. We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P = 9.4 x 10(-3), rs11889341; P = 1.2 x 10(-3), rs7574865; P = 4.0 x 10(-4), rs8179673; P = 2.0 x 10(-4), and rs10181656; P = 4.2 x 10(-5)). Three risk alleles (rs7574865; P = 0.040, rs8179673; P = 0.032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "DISEASE MARKERS. 2014:727393 (2014)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Joshita, Satoru", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html"}, {"subitem_link_text": "Umemura, Takeji", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html"}, {"subitem_link_text": "Matsumoto, Akihiro", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCPUym.html"}, {"subitem_link_text": "Tanaka, Eiji", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html"}, {"subitem_link_text": "Ota, Masao", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000331310600001"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "HINDAWI PUBLISHING CORPORATION"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "24648611"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/24648611", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1155/2014/727393"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1155/2014/727393", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright© 2011 Hindawi Publishing Corporation. This is an open access article distributed under the  Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0278-0240", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0278-0240", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10619879", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; JAPANESE PATIENTS; RISK; LOCI; PROGRESSION; POPULATION; HAPLOTYPE; VARIANTS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Recent genome-wide association studies suggest that genetic factors contribute to primary biliary cirrhosis (PBC) susceptibility. Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. Single nucleotide polymorphisms (SNPs) were genotyped in 395 PBC patients and 458 healthy subjects of Japanese ethnicity and evaluated for associations with PBC susceptibility, anti-nuclear antibody (ANA) status, and anti-mitochondrial antibody (AMA) status. We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P = 9.4 x 10(-3), rs11889341; P = 1.2 x 10(-3), rs7574865; P = 4.0 x 10(-4), rs8179673; P = 2.0 x 10(-4), and rs10181656; P = 4.2 x 10(-5)). Three risk alleles (rs7574865; P = 0.040, rs8179673; P = 0.032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Joshita,  Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22067", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umemura,  Takeji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22068", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura,  Minoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsuyama,  Yoshihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata,  Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura,  Takefumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita,  Susumu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu,  Michiharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22074", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto,  Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa,  Kaname", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22076", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishibashi,  Hiromi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  Masao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22079", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "STAT4_Gene_Polymorphisms_Associated_Susceptibility.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "STAT4_Gene_Polymorphisms_Associated_Susceptibility.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8023/files/STAT4_Gene_Polymorphisms_Associated_Susceptibility.pdf"}, "version_id": "eb4e2bd8-a988-4e4f-84fe-3b8c3e27f4e9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["883"], "permalink_uri": "http://hdl.handle.net/10091/17646", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-06-20"}, "publish_date": "2014-06-20", "publish_status": "0", "recid": "8023", "relation": {}, "relation_version_is_last": true, "title": ["STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis"], "weko_shared_id": -1}