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  1. 055 医学部附属病院
  2. 0551 学術論文

STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

http://hdl.handle.net/10091/17646
http://hdl.handle.net/10091/17646
21e4de89-d52a-40ac-a7a4-b0681080c4f6
名前 / ファイル ライセンス アクション
STAT4_Gene_Polymorphisms_Associated_Susceptibility.pdf STAT4_Gene_Polymorphisms_Associated_Susceptibility.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-20
タイトル
タイトル STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1155/2014/727393
関連名称 10.1155/2014/727393
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Joshita, Satoru

× Joshita, Satoru

en Joshita, Satoru

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Umemura, Takeji

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en Umemura, Takeji

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Nakamura, Minoru

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en Nakamura, Minoru

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Katsuyama, Yoshihiko

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en Katsuyama, Yoshihiko

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Shibata, Soichiro

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en Shibata, Soichiro

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Kimura, Takefumi

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en Kimura, Takefumi

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Morita, Susumu

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Komatsu, Michiharu

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Matsumoto, Akihiro

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Yoshizawa, Kaname

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Ishibashi, Hiromi

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Tanaka, Eiji

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Ota, Masao

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信州大学研究者総覧へのリンク
氏名 Joshita, Satoru
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html
信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Matsumoto, Akihiro
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCPUym.html
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
信州大学研究者総覧へのリンク
氏名 Ota, Masao
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述 DISEASE MARKERS. 2014:727393 (2014)
書誌情報 DISEASE MARKERS

巻 2014, p. 727393, 発行日 2014
抄録
内容記述 Recent genome-wide association studies suggest that genetic factors contribute to primary biliary cirrhosis (PBC) susceptibility. Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. Single nucleotide polymorphisms (SNPs) were genotyped in 395 PBC patients and 458 healthy subjects of Japanese ethnicity and evaluated for associations with PBC susceptibility, anti-nuclear antibody (ANA) status, and anti-mitochondrial antibody (AMA) status. We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P = 9.4 x 10(-3), rs11889341; P = 1.2 x 10(-3), rs7574865; P = 4.0 x 10(-4), rs8179673; P = 2.0 x 10(-4), and rs10181656; P = 4.2 x 10(-5)). Three risk alleles (rs7574865; P = 0.040, rs8179673; P = 0.032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0278-0240
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10619879
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24648611
関連名称 24648611
権利
権利情報 Copyright© 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000331310600001
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Cite as

Joshita, Satoru, Umemura, Takeji, Nakamura, Minoru, Katsuyama, Yoshihiko, Shibata, Soichiro, Kimura, Takefumi, Morita, Susumu, Komatsu, Michiharu, Matsumoto, Akihiro, Yoshizawa, Kaname, Ishibashi, Hiromi, Tanaka, Eiji, Ota, Masao, 2014, STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis: HINDAWI PUBLISHING CORPORATION, 727393– p.

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