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アイテム
Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
http://hdl.handle.net/10091/17346
http://hdl.handle.net/10091/1734633dc02ff-65cb-4e2d-b89c-289d9eeb65a9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Peroxisome_proliferator-activated_receptor_alpha_mediates.pdf (718.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-01-21 | |||||
| タイトル | ||||||
| タイトル | Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10719-012-9454-6 | |||||
| 関連名称 | 10.1007/s10719-012-9454-6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CST | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fenofibrate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PPAR alpha | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sphingoglycolipid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sulfoglycolipid | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nakajima, Takero
× Nakajima, Takero× Kamijo, Yuji× Huang, Yuzhe× Kimura, Takefumi× Tanaka, Naoki× Sugiyama, Eiko× Nakamura, Kozo× Kyogashima, Mamoru× Hara, Atsushi× Aoyama, Toshifumi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nakajima, Takero | |||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kamijo, Yuji | |||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nakamura, Kozo | |||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.upyCPUkh.html | |||||
| 出版者 | ||||||
| 出版者 | SPRINGER | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | GLYCOCONJUGATE JOURNAL. 30(6):553-560 (2013) | |||||
| 書誌情報 |
GLYCOCONJUGATE JOURNAL 巻 30, 号 6, p. 553-560, 発行日 2013-08 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Sulfatides, 3-O-sulfogalactosylceramides, are known to have multifunctional properties. These molecules are distributed in various tissues of mammals, where they are synthesized from galactosylceramides by sulfation at C3 of the galactosyl residue. Although this reaction is specifically catalyzed by cerebroside sulfotransferase (CST), the mechanisms underlying the transcriptional regulation of this enzyme are not understood. With respect to this issue, we previously found potential sequences of peroxisome proliferator-activated receptor (PPAR) response element on upstream regions of the mouse CST gene and presumed the possible regulation by the nuclear receptor PPAR alpha. To confirm this hypothesis, we treated wild-type and Ppara-null mice with the specific PPAR alpha agonist fenofibrate and examined the amounts of sulfatides and CST gene expression in various tissues. Fenofibrate treatment increased sulfatides and CST mRNA levels in the kidney, heart, liver, and small intestine in a PPAR alpha-dependent manner. However, these effects of fenofibrate were absent in the brain or colon. Fenofibrate treatment did not affect the mRNA level of arylsulfatase A, which is the key enzyme for catalyzing desulfation of sulfatides, in any of these six tissues. Analyses of the DNA-binding activity and conventional gene expression targets of PPAR alpha has demonstrated that fenofibrate treatment activated PPAR alpha in the kidney, heart, liver, and small intestine but did not affect the brain or colon. These findings suggest that PPAR alpha activation induces CST gene expression and enhances sulfatide synthesis in mice, which suggests that PPAR alpha is a possible transcriptional regulator for the mouse CST gene. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0282-0080 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10451191 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/23065187 | |||||
| 関連名称 | 23065187 | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at www.springerlink.com | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000322332900002 | |||||
