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  1. 055 医学部附属病院 (Hospital)
  2. 0551 学術論文 (Journal Articles)

Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs

http://hdl.handle.net/10091/17346
33dc02ff-65cb-4e2d-b89c-289d9eeb65a9
プレビュー
名前 / ファイル ライセンス Actions
Peroxisome_proliferator-activated_receptor_alpha_mediates.pdf Peroxisome_proliferator-activated_receptor_alpha_mediates.pdf (718.8 kB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2014-01-21
タイトル
タイトル Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
言語
言語 eng
キーワード
主題 CST
キーワード
主題 Fenofibrate
キーワード
主題 PPAR alpha
キーワード
主題 Sphingoglycolipid
キーワード
主題 Sulfoglycolipid
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakajima, Takero

× Nakajima, Takero

WEKO 22215

Nakajima, Takero

Search repository
Kamijo, Yuji

× Kamijo, Yuji

WEKO 22216

Kamijo, Yuji

Search repository
Huang, Yuzhe

× Huang, Yuzhe

WEKO 22217

Huang, Yuzhe

Search repository
Kimura, Takefumi

× Kimura, Takefumi

WEKO 22218

Kimura, Takefumi

Search repository
Tanaka, Naoki

× Tanaka, Naoki

WEKO 22219

Tanaka, Naoki

Search repository
Sugiyama, Eiko

× Sugiyama, Eiko

WEKO 22220

Sugiyama, Eiko

Search repository
Nakamura, Kozo

× Nakamura, Kozo

WEKO 22221

Nakamura, Kozo

Search repository
Kyogashima, Mamoru

× Kyogashima, Mamoru

WEKO 22222

Kyogashima, Mamoru

Search repository
Hara, Atsushi

× Hara, Atsushi

WEKO 22223

Hara, Atsushi

Search repository
Aoyama, Toshifumi

× Aoyama, Toshifumi

WEKO 22224

Aoyama, Toshifumi

Search repository
信州大学研究者総覧へのリンク
Nakajima, Takero
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html
信州大学研究者総覧へのリンク
Kamijo, Yuji
http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html
信州大学研究者総覧へのリンク
Nakamura, Kozo
http://soar-rd.shinshu-u.ac.jp/profile/ja.upyCPUkh.html
出版者
出版者 SPRINGER
引用
内容記述タイプ Other
内容記述 GLYCOCONJUGATE JOURNAL. 30(6):553-560 (2013)
書誌情報 GLYCOCONJUGATE JOURNAL

巻 30, 号 6, p. 553-560, 発行日 2013-08
抄録
内容記述タイプ Abstract
内容記述 Sulfatides, 3-O-sulfogalactosylceramides, are known to have multifunctional properties. These molecules are distributed in various tissues of mammals, where they are synthesized from galactosylceramides by sulfation at C3 of the galactosyl residue. Although this reaction is specifically catalyzed by cerebroside sulfotransferase (CST), the mechanisms underlying the transcriptional regulation of this enzyme are not understood. With respect to this issue, we previously found potential sequences of peroxisome proliferator-activated receptor (PPAR) response element on upstream regions of the mouse CST gene and presumed the possible regulation by the nuclear receptor PPAR alpha. To confirm this hypothesis, we treated wild-type and Ppara-null mice with the specific PPAR alpha agonist fenofibrate and examined the amounts of sulfatides and CST gene expression in various tissues. Fenofibrate treatment increased sulfatides and CST mRNA levels in the kidney, heart, liver, and small intestine in a PPAR alpha-dependent manner. However, these effects of fenofibrate were absent in the brain or colon. Fenofibrate treatment did not affect the mRNA level of arylsulfatase A, which is the key enzyme for catalyzing desulfation of sulfatides, in any of these six tissues. Analyses of the DNA-binding activity and conventional gene expression targets of PPAR alpha has demonstrated that fenofibrate treatment activated PPAR alpha in the kidney, heart, liver, and small intestine but did not affect the brain or colon. These findings suggest that PPAR alpha activation induces CST gene expression and enhances sulfatide synthesis in mice, which suggests that PPAR alpha is a possible transcriptional regulator for the mouse CST gene.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0282-0080
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10451191
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23065187
関連名称
関連名称 23065187
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s10719-012-9454-6
関連名称
関連名称 10.1007/s10719-012-9454-6
権利
権利情報 The final publication is available at www.springerlink.com
著者版フラグ
値 author
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000322332900002
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