Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-01-21 |
タイトル |
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タイトル |
Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1007/s10719-011-9329-2 |
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関連名称 |
10.1007/s10719-011-9329-2 |
キーワード |
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主題 |
Kidney transplantation, Oxidative stress, Platelet, Serum sulfatide |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Wang, Lixuan
Kamijo, Yuji
Matsumoto, Akihiro
Nakajima, Takero
Higuchi, Makoto
Kannagi, Reiji
Kyogashima, Mamoru
Aoyama, Toshifumi
Hara, Atsushi
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信州大学研究者総覧へのリンク |
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氏名 |
Kamijo, Yuji |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Nakajima, Takero |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html |
出版者 |
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出版者 |
SPRINGER |
引用 |
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内容記述 |
GLYCOCONJUGATE JOURNAL. 28(3-4):125-135 (2011) |
書誌情報 |
GLYCOCONJUGATE JOURNAL
巻 28,
号 3-4,
p. 125-135,
発行日 2011-05
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抄録 |
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内容記述 |
Sulfatide is a major component of glycosphingolipids in lipoproteins. Recently, we reported that a low serum level of sulfatide in hemodialysis patients might be related to the high incidence of cardiovascular diseases. However, the serum kinetics of sulfatide in kidney disease patients and the function of endogenous serum sulfatide are still unclear. To obtain novel knowledge concerning these issues, we investigated the serum kinetics of sulfatide in 5 adult kidney transplant recipients. We also analyzed the correlated factors influencing the serum sulfatide level, using multiple regression analysis. Kidney transplantation caused a dramatic increase of serum sulfatide without an alteration of its composition in all recipients in a time-dependent manner; however, the recovery speed was slower than that of the improvement of kidney function and the serum sulfatide reached a nearly normal level after 1 year. Multiple regression analysis showed that the significant correlated factor influencing the serum sulfatide level was log duration (time parameter) throughout the observation period, and the correlated factors detected in the stable phase were the decrease of serum concentration of malondialdehyde (an oxidative stress marker) as well as the elevation of platelet count. The current study results demonstrated the gradual but reliable recovery of the serum sulfatide level in kidney transplant recipients for the first time, suggesting a close correlation between serum sulfatide and kidney function. The recovery of serum sulfatide might derive from the attenuation of systemic oxidative stress. The normal level of serum sulfatide in kidney transplant recipients might affect platelet function, and contribute to the reduction of cardiovascular disease incidence. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0282-0080 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10451191 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21503857 |
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関連名称 |
21503857 |
権利 |
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権利情報 |
The final publication is available at www.springerlink.com |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000291243600003 |