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  1. 055 医学部附属病院
  2. 0551 学術論文

Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count

http://hdl.handle.net/10091/17345
http://hdl.handle.net/10091/17345
5dacfc24-095c-4d74-9da4-d5269fdeceaf
名前 / ファイル ライセンス アクション
Kidney_transplantation_recovers_reduction_level.pdf Kidney_transplantation_recovers_reduction_level.pdf (978.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-01-21
タイトル
言語 en
タイトル Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count
言語
言語 eng
キーワード
主題Scheme Other
主題 Kidney transplantation
キーワード
主題Scheme Other
主題 Oxidative stress
キーワード
主題Scheme Other
主題 Platelet
キーワード
主題Scheme Other
主題 Serum sulfatide
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Wang, Lixuan

× Wang, Lixuan

WEKO 22225

en Wang, Lixuan

Search repository
Kamijo, Yuji

× Kamijo, Yuji

WEKO 22226

en Kamijo, Yuji

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Matsumoto, Akihiro

× Matsumoto, Akihiro

WEKO 22227

en Matsumoto, Akihiro

Search repository
Nakajima, Takero

× Nakajima, Takero

WEKO 22228

en Nakajima, Takero

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 22229

en Higuchi, Makoto

Search repository
Kannagi, Reiji

× Kannagi, Reiji

WEKO 22230

en Kannagi, Reiji

Search repository
Kyogashima, Mamoru

× Kyogashima, Mamoru

WEKO 22231

en Kyogashima, Mamoru

Search repository
Aoyama, Toshifumi

× Aoyama, Toshifumi

WEKO 22232

en Aoyama, Toshifumi

Search repository
Hara, Atsushi

× Hara, Atsushi

WEKO 22233

en Hara, Atsushi

Search repository
信州大学研究者総覧へのリンク
氏名 Kamijo, Yuji
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html
信州大学研究者総覧へのリンク
氏名 Nakajima, Takero
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html
出版者
出版者 SPRINGER
引用
内容記述タイプ Other
内容記述 GLYCOCONJUGATE JOURNAL. 28(3-4):125-135 (2011)
書誌情報 GLYCOCONJUGATE JOURNAL

巻 28, 号 3-4, p. 125-135, 発行日 2011-05
抄録
内容記述タイプ Abstract
内容記述 Sulfatide is a major component of glycosphingolipids in lipoproteins. Recently, we reported that a low serum level of sulfatide in hemodialysis patients might be related to the high incidence of cardiovascular diseases. However, the serum kinetics of sulfatide in kidney disease patients and the function of endogenous serum sulfatide are still unclear. To obtain novel knowledge concerning these issues, we investigated the serum kinetics of sulfatide in 5 adult kidney transplant recipients. We also analyzed the correlated factors influencing the serum sulfatide level, using multiple regression analysis. Kidney transplantation caused a dramatic increase of serum sulfatide without an alteration of its composition in all recipients in a time-dependent manner; however, the recovery speed was slower than that of the improvement of kidney function and the serum sulfatide reached a nearly normal level after 1 year. Multiple regression analysis showed that the significant correlated factor influencing the serum sulfatide level was log duration (time parameter) throughout the observation period, and the correlated factors detected in the stable phase were the decrease of serum concentration of malondialdehyde (an oxidative stress marker) as well as the elevation of platelet count. The current study results demonstrated the gradual but reliable recovery of the serum sulfatide level in kidney transplant recipients for the first time, suggesting a close correlation between serum sulfatide and kidney function. The recovery of serum sulfatide might derive from the attenuation of systemic oxidative stress. The normal level of serum sulfatide in kidney transplant recipients might affect platelet function, and contribute to the reduction of cardiovascular disease incidence.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0282-0080
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10451191
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21503857
関連名称 21503857
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10719-011-9329-2
関連名称 10.1007/s10719-011-9329-2
権利
権利情報 The final publication is available at www.springerlink.com
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000291243600003
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