Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-05-14 |
タイトル |
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タイトル |
Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1093/hmg/ddr062 |
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関連名称 |
10.1093/hmg/ddr062 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Miyazaki, Daigo
Nakamura, Akinori
Fukushima, Kazuhiro
Yoshida, Kunihiro
Takeda, Shin'ichi
Ikeda, Shu-ichi
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信州大学研究者総覧へのリンク |
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氏名 |
Miyazaki, Daigo |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ZNShbVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Yoshida, Kunihiro |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.yhfNHFkh.html |
出版者 |
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出版者 |
OXFORD UNIV PRESS |
引用 |
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内容記述 |
HUMAN MOLECULAR GENETICS. 20(9):1787-1799 (2011) |
書誌情報 |
HUMAN MOLECULAR GENETICS
巻 20,
号 9,
p. 1787-1799,
発行日 2011
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抄録 |
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内容記述 |
Matrix metalloproteases (MMPs) are a family of endopeptidases classified into subgroups based on substrate preference in normal physiological processes such as embryonic development and tissue remodeling, as well as in various disease processes via degradation of extracellular matrix components. Among the MMPs, MMP-9 and MMP-2 have been reported to be up-regulated in skeletal muscles in the lethal X-linked muscle disorder Duchenne muscular dystrophy (DMD), which is caused by loss of dystrophin. A recent study showed that deletion of the MMP9 gene in mdx, a mouse model for DMD, improved skeletal muscle pathology and function; however, the role of MMP-2 in the dystrophin-deficient muscle is not well known. In this study, we aimed at verifying the role of MMP-2 in the dystrophin-deficient muscle by using mdx mice with genetic ablation of MMP-2 (mdx/MMP-2(-/-)). We found impairment of regenerated muscle fiber growth with reduction of angiogenesis in mdx/MMP-2(-/-) mice at 3 months of age. Expression of vascular endothelial growth factor-A (VEGF-A), an important angiogenesis-related factor, decreased in mdx/MMP-2(-/-) mice at 3 months of age. MMP-2 had not a critical role in the degradation of dystrophin-glycoprotein complex (DGC) components such as beta-dystroglycan and beta-sarcoglycan in the regeneration process of the dystrophic muscle. Accordingly, MMP-2 may be essential for growth of regenerated muscle fibers through VEGF-associated angiogenesis in the dystrophin-deficient skeletal muscle. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0964-6906 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10836720 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21320869 |
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関連名称 |
21320869 |
権利 |
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権利情報 |
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Molecular Genetics following peer review. The definitive publisher-authenticated version Hum. Mol. Genet. (2011) 20 (9): 1787-1799. is available online at: https://doi.org/10.1093/hmg/ddr062 . |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289311400011 |