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  1. 055 医学部附属病院
  2. 0551 学術論文

Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance

http://hdl.handle.net/10091/16948
e21ff0fd-ba2c-47d0-b850-f6ed3123d3b5
名前 / ファイル ライセンス アクション
Laser_captured_microdissection-microarray_analysis_genes_involved.pdf Laser_captured_microdissection-microarray_analysis_genes_involved.pdf (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-23
タイトル
言語 en
タイトル Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance
言語
言語 eng
キーワード
主題Scheme Other
主題 Endometrium
キーワード
主題Scheme Other
主題 Endometrial carcinoma
キーワード
主題Scheme Other
主題 Lipocalin2
キーワード
主題Scheme Other
主題 Microarray
キーワード
主題Scheme Other
主題 Laser-captured microdissection
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Miyamoto, Tsutomu

× Miyamoto, Tsutomu

WEKO 22289

en Miyamoto, Tsutomu

Search repository
Kashima, Hiroyasu

× Kashima, Hiroyasu

WEKO 22290

en Kashima, Hiroyasu

Search repository
Suzuki, Akihisa

× Suzuki, Akihisa

WEKO 22291

en Suzuki, Akihisa

Search repository
Kikuchi, Norihiko

× Kikuchi, Norihiko

WEKO 22292

en Kikuchi, Norihiko

Search repository
Konishi, Ikuo

× Konishi, Ikuo

WEKO 22293

en Konishi, Ikuo

Search repository
Seki, Naohiko

× Seki, Naohiko

WEKO 22294

en Seki, Naohiko

Search repository
Shiozawa, Tanri

× Shiozawa, Tanri

WEKO 22295

en Shiozawa, Tanri

Search repository
信州大学研究者総覧へのリンク
氏名 Miyamoto, Tsutomu
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.HmfpHVkh.html
信州大学研究者総覧へのリンク
氏名 Shiozawa, Tanri
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html
出版者
出版者 W B SAUNDERS CO-ELSEVIER INC
引用
内容記述タイプ Other
内容記述 HUMAN PATHOLOGY. 42(9):1265-1274 (2011)
書誌情報 HUMAN PATHOLOGY

巻 42, 号 9, p. 1265-1274, 発行日 2011-09
抄録
内容記述タイプ Abstract
内容記述 Endometrial carcinoma often arises from normal endometrial glandular cells via a precursor, atypical endometrial hyperplasia. However, the genetic changes involved in this carcinogenetic process are not fully understood. Differentially expressed genes were selected from glandular cells of normal proliferative-phase endometria, atypical endometrial hyperplasia, and endometrial carcinoma using laser-captured microdissection and microarray. The microarray analysis revealed a total of 51 genes to be up-regulated and 23 genes to be down-regulated in neoplastic endometrial epithelia. We focused on lipocalin2 (LCN2), which showed the largest magnitude of up-regulation. Immunostaining for lipocalin2 confirmed a stepwise increase in its expression in endometrial hyperplasia and carcinoma. In addition, elevated expression of lipocalin2 was correlated with the poor outcome of endometrial carcinoma patients. The subcellular distribution of lipocalin2 was both cytoplasmic and nuclear, despite reports that lipocalin2 is a secretory protein. Treatment of endometrial carcinoma cells with 5-azacytidine increased the expression of lipocalin2, suggesting the expression to be controlled by methylation of the promoter. The forced expression of lipocalin2 resulted in the enhanced cell proliferation and invasion in vitro. The expression of lipocalin2 increased with the endometrial carcinogenesis, and accumulation of the protein conferred biological aggressiveness to endometrial carcinoma cells. These results suggest lipocalin2 to be a novel target in the treatment of endometrial carcinoma.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0046-8177
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00666191
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21334721
関連名称
関連名称 21334721
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.humpath.2010.07.027
関連名称
関連名称 10.1016/j.humpath.2010.07.027
権利
権利情報 Copyright© 2011 Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294191000007
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