Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-04-01 |
タイトル |
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タイトル |
Successful Pregnancy and Lactation Outcome in a Patient With Gaucher Disease Receiving Enzyme Replacement Therapy, and the Subsequent Distribution and Excretion of Imiglucerase in Human Breast Milk |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.clinthera.2010.11.008 |
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関連名称 |
10.1016/j.clinthera.2010.11.008 |
キーワード |
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主題 |
Gaucher disease, glucocerebrosidase, enzyme replacement therapy, imiglucerase, lactation, human milk |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Sekijima, Yoshiki
Ohashi, Toya
Kosho, Tomoki
Fukushima, Yoshimitsu
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信州大学研究者総覧へのリンク |
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氏名 |
Sekijima, Yoshiki |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.WhLNuakh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Kosho, Tomoki |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.uhfpuakh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Fukushima, Yoshimitsu |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OUnVuUkh.html |
出版者 |
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出版者 |
ELSEVIER |
引用 |
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内容記述 |
CLINICAL THERAPEUTICS. 32(12):2048-2052 (2010) |
書誌情報 |
CLINICAL THERAPEUTICS
巻 32,
号 12,
p. 2048-2052,
発行日 2010-11
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抄録 |
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内容記述 |
Background: Enzyme replacement therapy (ERT) with imiglucerase is a well-established, effective treatment for Gaucher disease. However, there have been no published reports regarding the excretion of imiglucerase into human breast milk and its effects on the nursing infant. Objective: This letter reports on the successful pregnancy and lactation of a patient with Gaucher disease receiving treatment with imiglucerase, and the subsequent distribution and excretion of imiglucerase in human breast milk. Methods: A 39-year-old Japanese female (height, 164 cm; weight, 55 kg) with Gaucher disease had 2 successful pregnancies and continued ERT through both. The study was conducted 6 months after the first delivery. She was administered a 1-hour infusion of imiglucerase 60 U/kg that coincided with her regular every-2-week regimen. Serum and breast-milk samples were obtained before and up to 24 hours after administration. Breast-milk samples were also obtained from 10 nursing mothers with galactorrhea as controls. Results: The preinfusion level of breast-milk beta-glucocerebrosidase was 0.008 nmol/h/mL. The peak of serum beta-glucocerebrosidase activity (0.119 nmol/h/mL) was obtained at the end of the 1-hour infusion period. Slightly increased enzymatic activity (0.016 nmol/h/mL) was observed in the first breast milk sampled after imiglucerase infusion. Conclusions: We report a case of successful pregnancy and breastfeeding in a Japanese patient with Gaucher disease. A small amount of imiglucerase was found to be excreted into human breast milk, but only in the first milk produced after infusion. (Clin Ther. 2010;32:2048-2052) |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0149-2918 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00143411 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21118740 |
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関連名称 |
21118740 |
権利 |
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権利情報 |
Copyright© 2010 Elsevier HS Journals, Inc. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000285276800007 |