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Serum levels of sialylated carbohydrate antigen KL-6 (KL-6), a known marker of disease activity in fibrosing lung disorders, had been regularly measured once a month for early detection of IP, and had begun rising noticeably from 12 weeks to 540 U/mL at 33 weeks of treatment. On examination, remarkable fine crackles were detected by dorsal auscultation and bilateral ground-glass opacities and reticular shadows were depicted by computed tomography. 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Serum levels of sialylated carbohydrate antigen KL-6 (KL-6), a known marker of disease activity in fibrosing lung disorders, had been regularly measured once a month for early detection of IP, and had begun rising noticeably from 12 weeks to 540 U/mL at 33 weeks of treatment. On examination, remarkable fine crackles were detected by dorsal auscultation and bilateral ground-glass opacities and reticular shadows were depicted by computed tomography. The patient successfully recovered from her early-stage pneumonia by immediate discontinuation of therapy, which indicates that regular monitoring of serum KL-6 may be effective for avoidance of IP progression induced by PEG IFN and RBV therapy."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ichikawa-Yamada,  Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Joshita,  Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukahara,  Yoshinori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura,  Takefumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita,  Susumu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22402", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijo,  Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22403", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umemura,  Takeji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22404", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichijo,  Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22405", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto,  Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22406", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa,  Kaname", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22407", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22408", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Early_detection_interstitial_pneumonia_monitoring_KL-6.pdf", "filesize": [{"value": "322.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 322900.0, "url": {"label": "Early_detection_interstitial_pneumonia_monitoring_KL-6.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8068/files/Early_detection_interstitial_pneumonia_monitoring_KL-6.pdf"}, "version_id": "909f47ef-2e9f-42d9-8411-27ae34d37db6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "interstitial pneumonia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KL-6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pegylated interferon", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ribavirin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Early detection of interstitial pneumonia by monitoring KL-6 in a chronic hepatitis C patient undergoing pegylated interferon and ribavirin therapy", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Early detection of interstitial pneumonia by monitoring KL-6 in a chronic hepatitis C patient undergoing pegylated interferon and ribavirin therapy", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["882/883"], "permalink_uri": "http://hdl.handle.net/10091/16880", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-04-01"}, "publish_date": "2013-04-01", "publish_status": "0", "recid": "8068", "relation": {}, "relation_version_is_last": true, "title": ["Early detection of interstitial pneumonia by monitoring KL-6 in a chronic hepatitis C patient undergoing pegylated interferon and ribavirin therapy"], "weko_shared_id": 3}