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  1. 055 医学部附属病院
  2. 0551 学術論文

Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in the Freeze-Injured Mouse Urinary Bladder

http://hdl.handle.net/10091/16879
a1625110-2a28-49f5-9685-5353520d006c
名前 / ファイル ライセンス アクション
Differentiation_Smooth_Muscle_Cells_Human_Amniotic_Mesenchymal_Cells.pdf Differentiation_Smooth_Muscle_Cells_Human_Amniotic_Mesenchymal_Cells.pdf (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-01
タイトル
言語 en
タイトル Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in the Freeze-Injured Mouse Urinary Bladder
言語
言語 eng
キーワード
主題Scheme Other
主題 Regeneration
キーワード
主題Scheme Other
主題 Cell transplantation
キーワード
主題Scheme Other
主題 Mice
キーワード
主題Scheme Other
主題 Urinary bladder
キーワード
主題Scheme Other
主題 Bladder injury
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Minagawa, Tomonori

× Minagawa, Tomonori

WEKO 22409

en Minagawa, Tomonori

Search repository
Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 22410

en Imamura, Tetsuya

Search repository
Igawa, Yasuhiko

× Igawa, Yasuhiko

WEKO 22411

en Igawa, Yasuhiko

Search repository
Aizawa, Naoki

× Aizawa, Naoki

WEKO 22412

en Aizawa, Naoki

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 22413

en Ishizuka, Osamu

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 22414

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Minagawa, Tomonori
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 ELSEVIER SCIENCE BV
引用
内容記述タイプ Other
内容記述 EUROPEAN UROLOGY. 58(2):299-306 (2010)
書誌情報 EUROPEAN UROLOGY

巻 58, 号 2, p. 299-306, 発行日 2010-08
抄録
内容記述タイプ Abstract
内容記述 Background: The multipotency of human amniotic mesenchymal cells (HAMCs) has been reported, but the role of HAMCs in urinary tract regeneration is unknown. Objective: The aim of the study was to determine if cells derived from HAMCs support the structural and functional reconstruction of freeze-injured mouse bladders. Design, setting, and participants: HAMCs were harvested from an amnion membrane, and cells were cultured for 7 d prior to injection into the freeze-injured bladder walls of nude mice. Intervention: Three days prior to implantation, the posterior bladder walls were freeze injured for 30 s. The cultured HAMC-derived cells (0.5 x 10(5) cells per 50 mu l) were implanted into the injured regions. Control bladders received a cell-free injection. At 1, 2, 4, and 6 wk after the cell implantation, the experimental bladders were extirpated. Measurements: The bladder tissues were examined by immunohistochemistry for alpha-smooth muscle actin (SMA). The HAMC-derived cells were detected by antihuman nuclei antibody (HuNu). Separately, bladder muscle strips were examined for contractile responses to potassium. Results and limitations: At 1 wk after implantation, the HAMC-derived cells, which were detected by HuNu, differentiated into muscular layers composed of SMA-positive cells. From 2 to 6 wk after implantation, abundant layers of SMA-positive and HuNu-positive cells developed. In control bladders, few SMA-positive cells remained at the injured regions at 1 wk, but by 6 wk, more were present. At 1 wk, the contractile responses to potassium of the cell-implanted bladders were significantly higher than those of the control-injected ones. Control-injected bladders also recovered by 6 wk, but the rate of recovery was slower. Conclusions: Freeze-injured mouse bladders implanted with HAMC-derived cells recovered morphology and function faster than control-injected bladders.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0302-2838
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00639847
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20064685
関連名称
関連名称 20064685
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.eururo.2009.12.031
関連名称
関連名称 10.1016/j.eururo.2009.12.031
権利
権利情報 Copyright© 2009 European Association of Urology. Published by Elsevier B. V.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000279745100026
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