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Recently, a specific receptor for LCN2, solute carrier family 22 member 17 (SLC22A17), was identified. The present study was undertaken to investigate the expression of SLC22A17 in endometrial carcinoma. Methods: The expression of the SLC22A17 and LCN2 proteins was examined immunohistochemically using 69 cases of endometrial carcinoma and adjacent normal endometrial tissues. Immunoreactivity was evaluated according to the percentage of positive cells and described as a positivity index (PI, full score 100). Results: The expression of SLC22A17 was negligible in normal endometria, but positive staining for SLC22A17 (PI 1) was observed in 35 cases of endometrial carcinoma. The PI for SLC22A17 was significantly higher in cases with histological grade 3 (P \u003c 0.0005), advanced FIGO stage (P=0.002), deep myometrial invasion (P=0.029), positive lymph-vascular space invasion (P = 0.029), positive intraperitoneal cytology (P = 0.020) and adnexal metastasis (P= 0.029). 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  1. 055 医学部附属病院
  2. 0551 学術論文

Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma

http://hdl.handle.net/10091/16808
http://hdl.handle.net/10091/16808
4084862d-184e-45ed-959c-a62ae8221063
名前 / ファイル ライセンス アクション
Immunohistochemical_detection_specific_receptor_lipocalin2.pdf Immunohistochemical_detection_specific_receptor_lipocalin2.pdf (1.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-18
タイトル
言語 en
タイトル Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
言語
言語 eng
キーワード
主題Scheme Other
主題 Endometrium
キーワード
主題Scheme Other
主題 Endometrial carcinoma
キーワード
主題Scheme Other
主題 SLC22A17
キーワード
主題Scheme Other
主題 Lipocalin2
キーワード
主題Scheme Other
主題 Immunohistochemistry
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Miyamoto, Tsutomu

× Miyamoto, Tsutomu

WEKO 22460

en Miyamoto, Tsutomu

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Asaka, Ryouichi

× Asaka, Ryouichi

WEKO 22461

en Asaka, Ryouichi

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Suzuki, Akihisa

× Suzuki, Akihisa

WEKO 22462

en Suzuki, Akihisa

Search repository
Takatsu, Akiko

× Takatsu, Akiko

WEKO 22463

en Takatsu, Akiko

Search repository
Kashima, Hiroyasu

× Kashima, Hiroyasu

WEKO 22464

en Kashima, Hiroyasu

Search repository
Shiozawa, Tanri

× Shiozawa, Tanri

WEKO 22465

en Shiozawa, Tanri

Search repository
信州大学研究者総覧へのリンク
氏名 Miyamoto, Tsutomu
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.HmfpHVkh.html
信州大学研究者総覧へのリンク
氏名 Shiozawa, Tanri
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html
出版者
出版者 ACADEMIC PRESS INC ELSEVIER SCIENCE
引用
内容記述タイプ Other
内容記述 EXPERIMENTAL AND MOLECULAR PATHOLOGY. 91(2):563-568 (2011)
書誌情報 EXPERIMENTAL AND MOLECULAR PATHOLOGY

巻 91, 号 2, p. 563-568, 発行日 2011-10
抄録
内容記述タイプ Abstract
内容記述 Background: We previously reported the overexpression of lipocalin2 (LCN2), a 25 kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis. Recently, a specific receptor for LCN2, solute carrier family 22 member 17 (SLC22A17), was identified. The present study was undertaken to investigate the expression of SLC22A17 in endometrial carcinoma. Methods: The expression of the SLC22A17 and LCN2 proteins was examined immunohistochemically using 69 cases of endometrial carcinoma and adjacent normal endometrial tissues. Immunoreactivity was evaluated according to the percentage of positive cells and described as a positivity index (PI, full score 100). Results: The expression of SLC22A17 was negligible in normal endometria, but positive staining for SLC22A17 (PI 1) was observed in 35 cases of endometrial carcinoma. The PI for SLC22A17 was significantly higher in cases with histological grade 3 (P < 0.0005), advanced FIGO stage (P=0.002), deep myometrial invasion (P=0.029), positive lymph-vascular space invasion (P = 0.029), positive intraperitoneal cytology (P = 0.020) and adnexal metastasis (P= 0.029). The expression of SLC22A17 and LCN2 was positively correlated with a significant difference (P= 0.002), and the patients who overexpressed both SLC22A17 and LCN2 showed poorer survival than those without the expression of SLC22A17 or LCN2 (P= 0.002). Moreover, the overexpression of both SLC22A17 and LCN2 was indicated to be an independent prognostic factor by multivariable analysis. Conclusions: These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0014-4800
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00641168
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21763306
関連名称 21763306
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.yexmp.2011.06.002
関連名称 10.1016/j.yexmp.2011.06.002
権利
権利情報 Copyright© 2011 Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000295907700011
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