{"_buckets": {"deposit": "93299edd-57b6-4bff-9b86-08f818e77f5c"}, "_deposit": {"id": "8082", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8082"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00008082"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "859", "bibliographicPageStart": "849", "bibliographicVolumeNumber": "38", "bibliographic_titles": [{"bibliographic_title": "JAPANESE JOURNAL OF CLINICAL ONCOLOGY"}]}]}, "item_6_description_19": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "This is a pre-copy-editing, auyhor-produced PDF of an article forpublication in JAPANESE JOURNAL OF CLINICAL ONCOLOGY following peer review. The definitive publisher-authenticated version JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008) is available online at 10.1093/jjco/hyn114", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Matsumoto, K", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yFyhHekh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000261297900007"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "OXFORD UNIV PRESS"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1093/jjco/hyn114"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1093/jjco/hyn114", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0368-2811", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0368-2811", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00690866", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "MALIGNANT-MELANOMA; CELL-LINES; GROWTH-INHIBITION; INDUCTION; TUMORS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Cationic liposomes containing the human interferon beta (HuIFN beta) gene (IAB-1) was used for the clinical trial for glioma patients. HuIFN beta gene therapy showed much higher anti-tumor activity compared with the administration of HuIFN beta protein for melanoma. These results suggest that HuIFN beta gene therapy is an attractive strategy for the treatment of melanoma. Stage IV or III melanoma patients with cutaneous or subcutaneous metastatic lesions were enrolled in this pilot study. IAB-1 was dissolved by sterile PBS at a concentration of 30 mu g DNA/ml and was injected into cutaneous or subcutaneous metastatic nodules three times a week for 2 weeks and the effect on the injected and non-injected metastatic lesions was evaluated. Clinical responses were as follows (five patients): mixed response (MR) and no change in each one patient, and progressive disease in three patients. In the MR patient, the IAB-1 injected lesion disappeared clinically and histopathologically and one-half of IAB-1 non-injected skin metastases were transiently inflamed and mostly regressed. In the responded non-injected lesions of this patient, histopathologically, infiltration of CD4 positive T cells was observed around the melanoma cells in the dermis, which expressed the HLA-Class II antigen. Adverse events due to this gene therapy were not recognized in any of the patients. The efficacy of this gene therapy was generally insufficient; however, some immunological responses were recognized in one patient. No adverse events were observed. HuIFN beta gene therapy could be an attractive strategy for treatment of a variety of malignancies, including melanoma, though some modifications should be required."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsumoto,  K"}], "nameIdentifiers": [{"nameIdentifier": "22499", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo,  H"}], "nameIdentifiers": [{"nameIdentifier": "22500", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata,  H"}], "nameIdentifiers": [{"nameIdentifier": "22501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uhara,  H"}], "nameIdentifiers": [{"nameIdentifier": "22502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takata,  M"}], "nameIdentifiers": [{"nameIdentifier": "22503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata,  S"}], "nameIdentifiers": [{"nameIdentifier": "22504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasue,  S"}], "nameIdentifiers": [{"nameIdentifier": "22505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakakibara,  A"}], "nameIdentifiers": [{"nameIdentifier": "22506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita,  Y"}], "nameIdentifiers": [{"nameIdentifier": "22507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kageshita,  T"}], "nameIdentifiers": [{"nameIdentifier": "22508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami,  Y"}], "nameIdentifiers": [{"nameIdentifier": "22509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno,  M"}], "nameIdentifiers": [{"nameIdentifier": "22510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida,  J"}], "nameIdentifiers": [{"nameIdentifier": "22511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saida,  T"}], "nameIdentifiers": [{"nameIdentifier": "22512", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "A_Pilot_Study.pdf", "filesize": [{"value": "898.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 898300.0, "url": {"label": "A_Pilot_Study.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8082/files/A_Pilot_Study.pdf"}, "version_id": "d538e5bf-66e7-47e2-b8cd-aaa9275726fa"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes"}]}, "item_type_id": "6", "owner": "1", "path": ["882/883"], "permalink_uri": "http://hdl.handle.net/10091/3087", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2009-05-29"}, "publish_date": "2009-05-29", "publish_status": "0", "recid": "8082", "relation": {}, "relation_version_is_last": true, "title": ["A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes"], "weko_shared_id": 3}