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HuIFN beta gene therapy showed much higher anti-tumor activity compared with the administration of HuIFN beta protein for melanoma. These results suggest that HuIFN beta gene therapy is an attractive strategy for the treatment of melanoma. Stage IV or III melanoma patients with cutaneous or subcutaneous metastatic lesions were enrolled in this pilot study. IAB-1 was dissolved by sterile PBS at a concentration of 30 mu g DNA/ml and was injected into cutaneous or subcutaneous metastatic nodules three times a week for 2 weeks and the effect on the injected and non-injected metastatic lesions was evaluated. Clinical responses were as follows (five patients): mixed response (MR) and no change in each one patient, and progressive disease in three patients. In the MR patient, the IAB-1 injected lesion disappeared clinically and histopathologically and one-half of IAB-1 non-injected skin metastases were transiently inflamed and mostly regressed. In the responded non-injected lesions of this patient, histopathologically, infiltration of CD4 positive T cells was observed around the melanoma cells in the dermis, which expressed the HLA-Class II antigen. Adverse events due to this gene therapy were not recognized in any of the patients. The efficacy of this gene therapy was generally insufficient; however, some immunological responses were recognized in one patient. No adverse events were observed. 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A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes
http://hdl.handle.net/10091/3087
http://hdl.handle.net/10091/308780df0d3c-eee2-4652-952c-e4e05dd27d12
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-05-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Matsumoto, K
× Matsumoto, K× Kubo, H× Murata, H× Uhara, H× Takata, M× Shibata, S× Yasue, S× Sakakibara, A× Tomita, Y× Kageshita, T× Kawakami, Y× Mizuno, M× Yoshida, J× Saida, T |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Matsumoto, K | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.yFyhHekh.html | |||||
出版者 | ||||||
出版者 | OXFORD UNIV PRESS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008) | |||||
書誌情報 |
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 巻 38, 号 12, p. 849-859, 発行日 2008-12 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is a pre-copy-editing, auyhor-produced PDF of an article forpublication in JAPANESE JOURNAL OF CLINICAL ONCOLOGY following peer review. The definitive publisher-authenticated version JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008) is available online at 10.1093/jjco/hyn114 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0368-2811 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00690866 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/jjco/hyn114 | |||||
関連名称 | 10.1093/jjco/hyn114 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000261297900007 |