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However, the relationship between human calcium-activated chloride channel-1 (hCLCA1) and MUC5AC induced by IL-13 in vitro has not been fully investigated. Objectives: The present study examines whether IL-13 induces the expression of hCLCA1 in normal human bronchial epithelial (NHBE) cells. We also investigated the relationship between hCLCA1 and MUC5AC expression and the development of goblet cell hyperplasia (GCH). Methods: NHBE cells were isolated from human bronchi, and cultured with an air-liquid interface. hCLCA1 and MUC5AC gene and protein expression, as well as GCH were examined in the cells after exposure to IL-13. Results: Incubation with IL-13 for 14 and 21 days increased the total number of epithelial cells, the number of periodic acid-Schiff (PAS)-stained epithelial cells, the number of goblet cells, as well as expression of mRNA and protein of hCLCA1 and MUC5AC. The number of goblet cells with secretory granules also increased after 21 days of incubation with IL-13. Niflumic acid, a chloride channel inhibitor, reduced mRNA expression of hCLCA1 and MUC5AC, and reduced the number of PAS-positive cells after incubation with IL-13. NHBE cells exposed or not to IL-13 expressed IL-13 receptor alpha(1) (IL-13R alpha(1)), and an antibody to IL-13R alpha(1) also reduced the number of PAS-positive cells after exposure to IL-13. Conclusions: IL-13 might induce the expression of MUC5AC and hCLCA1 gene and protein in well-differentiated NHBE cells. These cells might also differentiate into goblet cells and become hyperplastic. Copyright (C) 2006 S. Karger AG, Basel."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasuo, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanabe, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yaegashi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsushima, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takasuna, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22553", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koike, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaya, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nikaido, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22556", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "calcium-activated_chloride_channel_1_and_MUC5AC.pdf", "filesize": [{"value": "288.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 288300.0, "url": {"label": "calcium-activated_chloride_channel_1_and_MUC5AC.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8089/files/calcium-activated_chloride_channel_1_and_MUC5AC.pdf"}, "version_id": "38d908cd-7b27-4238-967e-cdd4a692a947"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["883"], "permalink_uri": "http://hdl.handle.net/10091/1388", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-11-05"}, "publish_date": "2008-11-05", "publish_status": "0", "recid": "8089", "relation": {}, "relation_version_is_last": true, "title": ["Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells"], "weko_shared_id": -1}
Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells
http://hdl.handle.net/10091/1388
http://hdl.handle.net/10091/13881742f17f-e00c-42b4-aa15-6665eafa4d2d
名前 / ファイル | ライセンス | アクション |
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calcium-activated_chloride_channel_1_and_MUC5AC.pdf (288.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yasuo, M
× Yasuo, M× Fujimoto, K× Tanabe, T× Yaegashi, H× Tsushima, K× Takasuna, K× Koike, T× Yamaya, M× Nikaido, T |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Yasuo, M | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Fujimoto, K | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html | |||||
出版者 | ||||||
出版者 | Karger | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Respiration. 73(3):347-359 (2006) | |||||
書誌情報 |
Respiration 巻 73, 号 3, p. 347-359, 発行日 2006-02 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0025-7931 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00816840 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/16465045 | |||||
関連名称 | 16465045 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1159/000091391 | |||||
関連名称 | 10.1159/000091391 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000241775300015 |