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However, the relationship between human calcium-activated chloride channel-1 (hCLCA1) and MUC5AC induced by IL-13 in vitro has not been fully investigated. Objectives: The present study examines whether IL-13 induces the expression of hCLCA1 in normal human bronchial epithelial (NHBE) cells. We also investigated the relationship between hCLCA1 and MUC5AC expression and the development of goblet cell hyperplasia (GCH). Methods: NHBE cells were isolated from human bronchi, and cultured with an air-liquid interface. hCLCA1 and MUC5AC gene and protein expression, as well as GCH were examined in the cells after exposure to IL-13. Results: Incubation with IL-13 for 14 and 21 days increased the total number of epithelial cells, the number of periodic acid-Schiff (PAS)-stained epithelial cells, the number of goblet cells, as well as expression of mRNA and protein of hCLCA1 and MUC5AC. The number of goblet cells with secretory granules also increased after 21 days of incubation with IL-13. Niflumic acid, a chloride channel inhibitor, reduced mRNA expression of hCLCA1 and MUC5AC, and reduced the number of PAS-positive cells after incubation with IL-13. NHBE cells exposed or not to IL-13 expressed IL-13 receptor alpha(1) (IL-13R alpha(1)), and an antibody to IL-13R alpha(1) also reduced the number of PAS-positive cells after exposure to IL-13. Conclusions: IL-13 might induce the expression of MUC5AC and hCLCA1 gene and protein in well-differentiated NHBE cells. These cells might also differentiate into goblet cells and become hyperplastic. Copyright (C) 2006 S. Karger AG, Basel."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasuo,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanabe,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yaegashi,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsushima,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takasuna,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22553", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koike,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaya,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nikaido,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22556", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "calcium-activated_chloride_channel_1_and_MUC5AC.pdf", "filesize": [{"value": "288.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 288300.0, "url": {"label": "calcium-activated_chloride_channel_1_and_MUC5AC.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8089/files/calcium-activated_chloride_channel_1_and_MUC5AC.pdf"}, "version_id": "38d908cd-7b27-4238-967e-cdd4a692a947"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["883"], "permalink_uri": "http://hdl.handle.net/10091/1388", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-11-05"}, "publish_date": "2008-11-05", "publish_status": "0", "recid": "8089", "relation": {}, "relation_version_is_last": true, "title": ["Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells"], "weko_shared_id": -1}
  1. 055 医学部附属病院
  2. 0551 学術論文

Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells

http://hdl.handle.net/10091/1388
http://hdl.handle.net/10091/1388
1742f17f-e00c-42b4-aa15-6665eafa4d2d
名前 / ファイル ライセンス アクション
calcium-activated_chloride_channel_1_and_MUC5AC.pdf calcium-activated_chloride_channel_1_and_MUC5AC.pdf (288.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-11-05
タイトル
言語 en
タイトル Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yasuo, M

× Yasuo, M

WEKO 22548

en Yasuo, M

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Fujimoto, K

× Fujimoto, K

WEKO 22549

en Fujimoto, K

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Tanabe, T

× Tanabe, T

WEKO 22550

en Tanabe, T

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Yaegashi, H

× Yaegashi, H

WEKO 22551

en Yaegashi, H

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Tsushima, K

× Tsushima, K

WEKO 22552

en Tsushima, K

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Takasuna, K

× Takasuna, K

WEKO 22553

en Takasuna, K

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Koike, T

× Koike, T

WEKO 22554

en Koike, T

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Yamaya, M

× Yamaya, M

WEKO 22555

en Yamaya, M

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Nikaido, T

× Nikaido, T

WEKO 22556

en Nikaido, T

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信州大学研究者総覧へのリンク
氏名 Yasuo, M
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html
信州大学研究者総覧へのリンク
氏名 Fujimoto, K
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html
出版者
出版者 Karger
引用
内容記述タイプ Other
内容記述 Respiration. 73(3):347-359 (2006)
書誌情報 Respiration

巻 73, 号 3, p. 347-359, 発行日 2006-02
ISSN
収録物識別子タイプ PISSN
収録物識別子 0025-7931
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00816840
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/16465045
関連名称 16465045
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1159/000091391
関連名称 10.1159/000091391
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000241775300015
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