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The effect of matured date palm tree (Phoenix dactylifera L.) fruit extract on mite- induced allergic symptoms in NC/Nga mice
http://hdl.handle.net/10091/17350
http://hdl.handle.net/10091/173508d69988e-ea79-430b-94a5-d0fd86f68dc4
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2014-01-21 | |||||||||
タイトル | ||||||||||
タイトル | The effect of matured date palm tree (Phoenix dactylifera L.) fruit extract on mite- induced allergic symptoms in NC/Nga mice | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
DOI | ||||||||||
関連識別子 | https://doi.org/10.1080/09540105.2012.733353 | |||||||||
関連名称 | 10.1080/09540105.2012.733353 | |||||||||
キーワード | ||||||||||
主題 | anti-allergic property, polyphenol, mast cell, Tec family kinase, NC, Nga mouse | |||||||||
資源タイプ | ||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
タイプ | journal article | |||||||||
著者 |
Karasawa, Koji
× Karasawa, Koji
× Otani, Hajime
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出版者 | ||||||||||
出版者 | Taylor & Francis | |||||||||
引用 | ||||||||||
内容記述 | FOOD AND AGRICULTURAL IMMUNOLOGY. 25(1):49-60 (2014) | |||||||||
書誌情報 |
FOOD AND AGRICULTURAL IMMUNOLOGY 巻 25, 号 1, p. 49-60, 発行日 2014-01-02 |
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抄録 | ||||||||||
内容記述 | The effect of a hot water extract of matured date palm tree fruit on allergic responses was investigated in NC/Nga mice. The allergic score was significantly reduced in the mice fed a date palm tree fruit extract-added diet than the fruit extract-free diet. The levels of serum antigen-specific immunoglobulin E and spleen interleukin (IL)-4+CD4+ cells were significantly lowered in the mice fed the fruit extract-added diet. Bruton's tyrosine kinase (Btk) and IL-2-inducible T cell kinase (Itk) mRNA expressions in spleen cells were significantly lowered in the mice fed the fruit extract-added diet. Moreover, chlorogenic acid and pelargonin decreased these mRNA expressions in C3H/HeN mouse spleen cell cultures. These results suggest that the date palm tree fruit extract may reduce allergic symptoms in mice via a decrease in the number of type 2 helper T (Th2) cells, and a suppression of the expression of kinases involved in mast cell degranulation and Th2 cell differentiation. | |||||||||
資源タイプ(コンテンツの種類) | ||||||||||
内容記述 | Article | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0954-0105 | |||||||||
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収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA10779820 | |||||||||
権利 | ||||||||||
権利情報 | This is an Author's Accepted Manuscript of an article published in Food and Agricultural Immunology. 25(1):49-60 (2014), Published online: 30 Oct 2012, Copyright© 2012 Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/09540105.2012.733353 . | |||||||||
出版タイプ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
WoS | ||||||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000329545900005 |