Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-12-02 |
タイトル |
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タイトル |
Anti-allergic Properties of a Fruit Extract of Prune (Prunus domestica L.), in Mite-sensitized BALB/c Mice |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.3136/fstr.18.755 |
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関連名称 |
10.3136/fstr.18.755 |
キーワード |
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主題 |
anti-allergic property, prune extract, immunoglobulin E, helper T cell subsets, degranulation |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Karasawa, Koji
Miyashita, Ryoji
Otani, Hajime
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出版者 |
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出版者 |
KARGER |
引用 |
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内容記述 |
FOOD SCIENCE AND TECHNOLOGY RESEARCH. 18(5):755-760 (2012) |
書誌情報 |
FOOD SCIENCE AND TECHNOLOGY RESEARCH
巻 18,
号 5,
p. 755-760,
発行日 2012-09
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抄録 |
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内容記述 |
The effects of oral ingestion of a hot water extract of prune (Prunus domestica L.) fruit on allergic responses were investigated in mite-sensitized BALB/c mice. The number of sneezing events in mice given the extract-added diet was significantly lower than in mice given the extract-free diet. Serum mite allergen-specific immunoglobulin E levels were significantly lower in mice given the extract-added diet than in mice given the extract-free diet. In contrast, the ratio of splenic IFN-gamma(+)CD4(+) cells/IL-4(+)CD4(+) cells was higher in mice given the extract-added diet. Expression levels of Stat6, Btk and Stim1 mRNAs in spleen cells of mice given the extract-added diet were significantly lower than in mice given the extract-free diet. These results suggest that the prune extract may reduce type I allergic symptoms in mice via the adjustment of type 1 helper T cell/type 2 helper T cell balance and the suppression of mast cell degranulation. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1344-6606 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11320122 |
権利 |
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権利情報 |
Copyright (c) 2012 Japanese Society for Food Science and Technology |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000310098300021 |