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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice

http://hdl.handle.net/10091/13191
http://hdl.handle.net/10091/13191
5495759b-583b-4854-b8ce-045f9e5d9a86
名前 / ファイル ライセンス アクション
Anti-allergic_effects_mixture_Saccharomyces.pdf Anti-allergic_effects_mixture_Saccharomyces.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-06-20
タイトル
タイトル Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice
言語
言語 eng
キーワード
主題 14 Allergy, 14 Allergie, mouse model, Mausmodell, antiallergic effects, antiallergische Effekte, Saccharomyces cerevisiaelgoal's milk, Saccharomyces cerevisiaelZiegenmilch-lgG
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sekekimura, Yumi

× Sekekimura, Yumi

Sekekimura, Yumi

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Shimosato, Takeshi

× Shimosato, Takeshi

Shimosato, Takeshi

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Otani, Hajime

× Otani, Hajime

Otani, Hajime

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信州大学研究者総覧へのリンク
氏名 Shimosato, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
出版者
出版者 A V A AGRARVERLAG
引用
内容記述 MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 66(1): 7-10(2011)
書誌情報 MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL

巻 66, 号 1, p. 7-10, 発行日 2011
抄録
内容記述 In this study, we investigated the effects of oral ingestion of Saccharomyces (S.) cerevisiae and its specific immunoglobulin (Ig) G-rich fraction, prepared from goat's milk, on immune function in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a feed containing a mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction (mixture group) was significantly lower than that in mice administered the mixture-free feed (control group) at age 11 and 12 weeks, although the activity in mice that were given a feed containing S. cerevisiae (yeast group) was similar to that of the control group. We found that the ratio of spleen interferon-gamma(+)CD4(+) cell/interleukin (IL)-4(+)CD4(+) cell was higher in the mixture and yeast groups than the control group. The number of spleen CD80(+)CD11b(+) cells was significantly lower in the mixture and yeast groups than the control group. In contrast, the numbers of spleen CD122(+)CD8 alpha(+) and IL-10(+)CD4(+) cells were significantly higher in the mixture group than the control and yeast groups while the numbers of IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells were significantly lower in the mixture group. These results suggested that the mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction reduced OVA-induced allergic symptoms in BALB/c mice via the induction of suppressor T cells and the reduction of Ig E-producing cells and high affinity IgE receptor-positive mast cells rather than the adjustment of the Th1/Th2 balance.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ ISSN
収録物識別子 0026-3788
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00285427
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000287643600002
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