Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2011-06-20 |
タイトル |
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タイトル |
Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice |
言語 |
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言語 |
eng |
キーワード |
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主題 |
14 Allergy, 14 Allergie, mouse model, Mausmodell, antiallergic effects, antiallergische Effekte, Saccharomyces cerevisiaelgoal's milk, Saccharomyces cerevisiaelZiegenmilch-lgG |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Sekekimura, Yumi
Shimosato, Takeshi
Otani, Hajime
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信州大学研究者総覧へのリンク |
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氏名 |
Shimosato, Takeshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
出版者 |
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出版者 |
A V A AGRARVERLAG |
引用 |
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内容記述 |
MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 66(1): 7-10(2011) |
書誌情報 |
MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL
巻 66,
号 1,
p. 7-10,
発行日 2011
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抄録 |
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内容記述 |
In this study, we investigated the effects of oral ingestion of Saccharomyces (S.) cerevisiae and its specific immunoglobulin (Ig) G-rich fraction, prepared from goat's milk, on immune function in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a feed containing a mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction (mixture group) was significantly lower than that in mice administered the mixture-free feed (control group) at age 11 and 12 weeks, although the activity in mice that were given a feed containing S. cerevisiae (yeast group) was similar to that of the control group. We found that the ratio of spleen interferon-gamma(+)CD4(+) cell/interleukin (IL)-4(+)CD4(+) cell was higher in the mixture and yeast groups than the control group. The number of spleen CD80(+)CD11b(+) cells was significantly lower in the mixture and yeast groups than the control group. In contrast, the numbers of spleen CD122(+)CD8 alpha(+) and IL-10(+)CD4(+) cells were significantly higher in the mixture group than the control and yeast groups while the numbers of IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells were significantly lower in the mixture group. These results suggested that the mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction reduced OVA-induced allergic symptoms in BALB/c mice via the induction of suppressor T cells and the reduction of Ig E-producing cells and high affinity IgE receptor-positive mast cells rather than the adjustment of the Th1/Th2 balance. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0026-3788 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00285427 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000287643600002 |