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Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice
http://hdl.handle.net/10091/13191
5495759b-583b-4854-b8ce-045f9e5d9a86
名前 / ファイル | ライセンス | Actions | |
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item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-06-20 | |||||
タイトル | ||||||
タイトル | Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | 14 Allergy | |||||
キーワード | ||||||
主題 | 14 Allergie | |||||
キーワード | ||||||
主題 | mouse model | |||||
キーワード | ||||||
主題 | Mausmodell | |||||
キーワード | ||||||
主題 | antiallergic effects | |||||
キーワード | ||||||
主題 | antiallergische Effekte | |||||
キーワード | ||||||
主題 | Saccharomyces cerevisiaelgoal's milk | |||||
キーワード | ||||||
主題 | Saccharomyces cerevisiaelZiegenmilch-lgG | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sekekimura, Yumi
× Sekekimura, Yumi× Shimosato, Takeshi× Otani, Hajime |
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信州大学研究者総覧へのリンク | ||||||
Shimosato, Takeshi | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html | ||||||
出版者 | ||||||
出版者 | A V A AGRARVERLAG | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 66(1): 7-10(2011) | |||||
書誌情報 |
MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL 巻 66, 号 1, p. 7-10, 発行日 2011 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we investigated the effects of oral ingestion of Saccharomyces (S.) cerevisiae and its specific immunoglobulin (Ig) G-rich fraction, prepared from goat's milk, on immune function in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a feed containing a mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction (mixture group) was significantly lower than that in mice administered the mixture-free feed (control group) at age 11 and 12 weeks, although the activity in mice that were given a feed containing S. cerevisiae (yeast group) was similar to that of the control group. We found that the ratio of spleen interferon-gamma(+)CD4(+) cell/interleukin (IL)-4(+)CD4(+) cell was higher in the mixture and yeast groups than the control group. The number of spleen CD80(+)CD11b(+) cells was significantly lower in the mixture and yeast groups than the control group. In contrast, the numbers of spleen CD122(+)CD8 alpha(+) and IL-10(+)CD4(+) cells were significantly higher in the mixture group than the control and yeast groups while the numbers of IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells were significantly lower in the mixture group. These results suggested that the mixture of S. cerevisiae and its specific goat's milk IgG-rich fraction reduced OVA-induced allergic symptoms in BALB/c mice via the induction of suppressor T cells and the reduction of Ig E-producing cells and high affinity IgE receptor-positive mast cells rather than the adjustment of the Th1/Th2 balance. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0026-3788 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00285427 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
WoS | ||||||
Web of Science | ||||||
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000287643600002 |