Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2011-06-20 |
タイトル |
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タイトル |
Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1111/j.1740-0929.2010.00795.x |
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関連名称 |
10.1111/j.1740-0929.2010.00795.x |
キーワード |
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主題 |
anti-allergic effect, antigen-presenting cells, Lactobacillus crispatus KT-11, mast cells, Th1, Th2 balance |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Tobita, Keisuke
Yanaka, Hiroyuki
Otani, Hajime
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出版者 |
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出版者 |
Blackwell Publishing |
引用 |
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内容記述 |
ANIMAL SCIENCE JOURNAL. 81(6):699-705 (2010) |
書誌情報 |
ANIMAL SCIENCE JOURNAL
巻 81,
号 6,
p. 699-705,
発行日 2010-12
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内容記述 |
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内容記述 |
The definitive version is available at www.blackwell-synergy.com |
抄録 |
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内容記述 |
In this study, we investigated the effects of oral ingestion of Lactobacillus crispatus KT-11 strain (KT-11) on the immune response in an allergic rhinitis mouse model, ovalbumin (OVA)-sensitized BALB/c mice. Sneezing activity in mice that were administered a KT-11-supplemented diet was significantly lower than that in mice administered a KT-11-free diet (control diet) at age 11 weeks. We found that serum OVA-specific immunoglobulin E (IgE) levels and total number of interleukin (IL)-4+CD4+ spleen cells in mice that were administered a KT-11-supplemented diet were significantly lower than in mice administered a control diet. The ratio of spleen interferon-gamma+CD4+/IL-4+CD4+ cells was higher in the mice administered the KT-11-supplemented diet compared to that in mice administered the control or L. rhamnosus GG-supplemented diet. In contrast, the number of CD11b+CD80+ and Fc epsilon RI alpha+CD117+ cells was significantly lower in mice administered the KT-11-supplemented diet. These results suggested that KT-11 reduced OVA-induced allergic symptoms in BALB/c mice via the adjustment of the T helper type 1/T helper type 2 balance, and a decrease in the number of antigen-presenting cells and high affinity IgE receptor-positive mast cells. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1344-3941 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11677214 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21108691/ |
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関連名称 |
21108691 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000284643800012 |