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Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx
http://hdl.handle.net/10091/00018689
http://hdl.handle.net/10091/000186897fe807c8-8219-4cc7-bf09-79ca236c3498
| 名前 / ファイル | ライセンス | アクション |
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Disruption_of_diapause_induction_by_TALEN-based_gene.pdf (2.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2016-03-23 | |||||||||||||||||||||||
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| タイトル | Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep15566 | |||||||||||||||||||||||
| 関連名称 | 10.1038/srep15566 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Shiomi, Kunihiro
× Shiomi, Kunihiro
× Takasu, Yoko
× Kunii, Masayo
× Tsuchiya, Ryoma
× Mukaida, Moeka
× Kobayashi, Masakazu
× Sezutsu, Hideki
× Ichida, (Takahama), Masatoshi
× Mizoguchi, Akira
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Shiomi, Kunihiro | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WCnpjFkV.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | NATURE PUBLISHING GROUP | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | SCIENTIFIC REPORTS. 5:15566 (2015) | |||||||||||||||||||||||
| 書誌情報 |
SCIENTIFIC REPORTS 巻 5, p. 15566, 発行日 2015-10-26 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | The insect neuropeptide family FXPRLa, which carries the Phe-Xaa-Pro-Arg-Leu-NH2 sequence at the C-terminus, is involved in many physiological processes. Although ligand–receptor interactions in FXPRLa signaling have been examined using in vitro assays, the correlation between these interactions and in vivo physiological function is unclear. Diapause in the silkworm, Bombyx mori, is thought to be elicited by diapause hormone (DH, an FXPRLa) signaling, which consists of interactions between DH and DH receptor (DHR). Here, we performed transcription activator-like effector nuclease (TALEN)-based mutagenesis of the Bombyx DH-PBAN and DHR genes and isolated the null mutants of these genes in a bivoltine strain. All mutant silkworms were fully viable and showed no abnormalities in the developmental timing of ecdysis or metamorphosis. However, female adults oviposited non-diapause eggs despite diapause-inducing temperature and photoperiod conditions. Therefore, we conclude that DH signaling is essential for diapause induction and consists of highly sensitive and specific interactions between DH and DHR selected during ligand–receptor coevolution in Bombyx mori. | |||||||||||||||||||||||
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| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=26497859 | |||||||||||||||||||||||
| 関連名称 | 26497859 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000363397200001 | |||||||||||||||||||||||
