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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice

http://hdl.handle.net/10091/00018785
ad35fc8b-b3ab-41c7-843a-93a49a3e2e2e
名前 / ファイル ライセンス アクション
Oral_delivery_Lactococcus_lactis_secretes.pdf Oral_delivery_Lactococcus_lactis_secretes.pdf (6.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-04-22
タイトル
言語 en
タイトル Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
言語
言語 eng
キーワード
主題Scheme Other
主題 Lactococcus lactis
キーワード
主題Scheme Other
主題 Heme oxygenase-1
キーワード
主題Scheme Other
主題 Acute colitis
キーワード
主題Scheme Other
主題 Interleukin-10
キーワード
主題Scheme Other
主題 Mice
キーワード
主題Scheme Other
主題 Inflammatory bowel disease
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shigemori, Suguru

× Shigemori, Suguru

WEKO 50381

Shigemori, Suguru

Search repository
Watanabe, Takafumi

× Watanabe, Takafumi

WEKO 50382

Watanabe, Takafumi

Search repository
Kudoh, Kai

× Kudoh, Kai

WEKO 50383

Kudoh, Kai

Search repository
Ihara, Masaki

× Ihara, Masaki

WEKO 50384

Ihara, Masaki

Search repository
Nigar, Shireen

× Nigar, Shireen

WEKO 50385

Nigar, Shireen

Search repository
Yamamoto, Yoshinari

× Yamamoto, Yoshinari

WEKO 50386

Yamamoto, Yoshinari

Search repository
Suda, Yoshihito

× Suda, Yoshihito

WEKO 50387

Suda, Yoshihito

Search repository
Sato, Takashi

× Sato, Takashi

WEKO 50388

Sato, Takashi

Search repository
Kitazawa, Haruki

× Kitazawa, Haruki

WEKO 50389

Kitazawa, Haruki

Search repository
Shimosato, Takeshi

× Shimosato, Takeshi

WEKO 50390

Shimosato, Takeshi

Search repository
信州大学研究者総覧へのリンク
氏名 Ihara, Masaki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jpkaWUyV.html
信州大学研究者総覧へのリンク
氏名 Shimosato, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
出版者
出版者 BIOMED CENTRAL LTD
引用
内容記述タイプ Other
内容記述 MICROBIAL CELL FACTORIES. 14:189 (2015)
書誌情報 MICROBIAL CELL FACTORIES

巻 14, 発行日 2015-11-15
抄録
内容記述タイプ Abstract
内容記述 Background: Mucosal delivery of therapeutic proteins using genetically modified strains of lactic acid bacteria (gmLAB) is being investigated as a new therapeutic strategy. Methods: We developed a strain of gmLAB, Lactococcus lactis NZ9000 (NZ-HO), which secretes the anti-inflammatory molecule recombinant mouse heme oxygenase-1 (rmHO-1). The effects of short-term continuous oral dosing with NZ-HO were evaluated in mice with dextran sulfate sodium (DSS)-induced acute colitis as a model of inflammatory bowel diseases (IBD). Results: We identified the secretion of rmHO-1 by NZ-HO. rmHO-1 was biologically active as determined with spectroscopy. Viable NZ-HO was directly delivered to the colon via oral administration, and rmHO-1 was secreted onto the colonic mucosa in mice. Acute colitis in mice was induced by free drinking of 3 % DSS in water and was accompanied by an increase in the disease activity index score and histopathological changes. Daily oral administration of NZ-HO significantly improved these colitis-associated symptoms. In addition, NZ-HO significantly increased production of the anti-inflammatory cytokine interleukin (IL)-10 and decreased the expression of pro-inflammatory cytokines such as IL-1 alpha and IL-6 in the colon compared to a vector control strain. Conclusions: Oral administration of NZ-HO alleviates DSS-induced acute colitis in mice. Our results suggest that NZ-HO may be a useful mucosal therapeutic agent for treating IBD.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1475-2859
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12039472
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=26608030
関連名称
関連名称 26608030
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12934-015-0378-2
関連名称
関連名称 10.1186/s12934-015-0378-2
権利
権利情報 Copyright © Shigemori et al. 2015
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000365270300002
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