{"_buckets": {"deposit": "33841285-bda9-47d9-b708-361c06526472"}, "_deposit": {"id": "18972", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18972"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00018972", "sets": []}, "author_link": ["103706"], "item_14_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2016-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u4fe1\u5dde\u5927\u5b66(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_14_description_26": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u96d1\u8a8c\u306b\u767a\u8868\u3002PEDIATRIC BLOOD \u0026 CANCER. 64(3):e26259 (2017); doi:10.1002/pbc.26259.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "LE THANH NHA UYEN. Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia\uff08\u5c0f\u5150\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c8\u30ab\u30c9\u30d8\u30ea\u30f317\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30e1\u30c1\u30eb\u5316\u3068\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\uff09. \u4fe1\u5dde\u5927\u5b66, 2016, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1072\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000397225000012"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27643535"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27643535", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1002/pbc.26259"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/pbc.26259", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: Uyen, T. N., Sakashita, K., Al-Kzayer, L. F. Y., Nakazawa, Y., Kurata, T. and Koike, K. (2017), Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer, 64: n/a, e26259. , which has been published in final form at https://doi.org/10.1002/pbc.26259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1072\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "BCP ALL; DNA methylation; PCDH17; prognostic factors; relapse"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CPG ISLAND; EXPRESSION; RESISTANCE; CANCERS; MECHANISMS; REVEALS; RELAPSE; CELLS; P15"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background: The outcome of approximately 20% of patients with acute lymphoblastic leukemia (ALL) remains poor because of disease recurrence. We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. Procedure: We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation status of each individual gene was then determined by a combination of bisulfite restriction analysis and genome bisulfite sequencing. mRNAexpression was evaluated by reverse-transcriptase PCR (RT-PCR) and quantitative real-time PCR. Results: Cadherin superfamily genes including cadherin (CDH) 1, protocadherin (PCDH) 8, and PCDH17 were selected for analysis of methylation status. In 40 patient samples with B-cell precursor (BCP) ALL at diagnosis, the methylation frequencies of CDH1, PCDH8, and PCDH17 were 62.5, 55, and 30%, respectively. CDH1 and PCDH8 methylation was also detected in 80 and 20% of control bone marrow (BM) samples, respectively. On the contrary, PCDH17 was unmethylated in all control BM samples. There was a significant correlation between the methylation status of PCDH17 (but not CDH1 and PCDH8) and event-free survival or overall survival. Univariate and multivariate analyses showed that only PCDH17 methylation was associated with an increased risk for relapse and mortality in patients with BCP ALL. Conclusion: PCDH17 methylation at diagnosis was closely related to poor prognosis and thus could be used as a new biomarker to predict relapse in patients with BCP ALL."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "LE, THANH NHA UYEN"}], "nameIdentifiers": [{"nameIdentifier": "103706", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "12MH044A_shinsa.pdf", "filesize": [{"value": "116.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 116600.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18972/files/12MH044A_shinsa.pdf"}, "version_id": "f68ede69-df8a-4fe0-933e-4550ffec684d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "12MH044A_yoshi.pdf", "filesize": [{"value": "133.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 133300.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18972/files/12MH044A_yoshi.pdf"}, "version_id": "c28a964c-0b5b-4db5-a306-af4cdaa054c6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "12MH044A_ronbun.pdf", "filesize": [{"value": "771.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is the peer reviewed version of the following article: Uyen, T. N., Sakashita, K., Al-Kzayer, L. F. Y., Nakazawa, Y., Kurata, T. and Koike, K. (2017), Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer, 64: n/a, e26259. , which has been published in final form at https://doi.org/10.1002/pbc.26259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 771300.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/18972/files/12MH044A_ronbun.pdf"}, "version_id": "bdc2cb73-e986-436d-a9db-89a9ace4c428"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia\uff08\u5c0f\u5150\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c8\u30ab\u30c9\u30d8\u30ea\u30f317\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30e1\u30c1\u30eb\u5316\u3068\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia\uff08\u5c0f\u5150\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c8\u30ab\u30c9\u30d8\u30ea\u30f317\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30e1\u30c1\u30eb\u5316\u3068\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00019734", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18972", "relation": {}, "relation_version_is_last": true, "title": ["Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia\uff08\u5c0f\u5150\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c8\u30ab\u30c9\u30d8\u30ea\u30f317\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30e1\u30c1\u30eb\u5316\u3068\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\uff09"], "weko_shared_id": -1}