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We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. Procedure: We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation status of each individual gene was then determined by a combination of bisulfite restriction analysis and genome bisulfite sequencing. mRNAexpression was evaluated by reverse-transcriptase PCR (RT-PCR) and quantitative real-time PCR. Results: Cadherin superfamily genes including cadherin (CDH) 1, protocadherin (PCDH) 8, and PCDH17 were selected for analysis of methylation status. In 40 patient samples with B-cell precursor (BCP) ALL at diagnosis, the methylation frequencies of CDH1, PCDH8, and PCDH17 were 62.5, 55, and 30%, respectively. CDH1 and PCDH8 methylation was also detected in 80 and 20% of control bone marrow (BM) samples, respectively. On the contrary, PCDH17 was unmethylated in all control BM samples. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討)

http://hdl.handle.net/10091/00019734
9965428a-c666-4889-82e3-14f4c2721f6c
名前 / ファイル ライセンス アクション
12MH044A_shinsa.pdf 内容の要旨 (116.6 kB)
12MH044A_yoshi.pdf 審査結果の要旨 (133.3 kB)
12MH044A_ronbun.pdf 博士論文の全文 (771.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-06-06
タイトル
言語 en
タイトル Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 LE, THANH NHA UYEN

× LE, THANH NHA UYEN

WEKO 103706

LE, THANH NHA UYEN

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 LE THANH NHA UYEN. Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討). 信州大学, 2016, 博士論文.
書誌情報
発行日 2016-03-31
学位授与番号
学位授与番号 13601甲第1072号
学位授与年月日
学位授与年月日 2016-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1072号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。PEDIATRIC BLOOD & CANCER. 64(3):e26259 (2017); doi:10.1002/pbc.26259.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27643535
関連名称
関連名称 27643535
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/pbc.26259
関連名称
関連名称 10.1002/pbc.26259
権利
権利情報 This is the peer reviewed version of the following article: Uyen, T. N., Sakashita, K., Al-Kzayer, L. F. Y., Nakazawa, Y., Kurata, T. and Koike, K. (2017), Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer, 64: n/a, e26259. , which has been published in final form at https://doi.org/10.1002/pbc.26259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000397225000012
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