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Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia\uff08\u5c0f\u5150\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c8\u30ab\u30c9\u30d8\u30ea\u30f317\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30e1\u30c1\u30eb\u5316\u3068\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\uff09. \u4fe1\u5dde\u5927\u5b66, 2016, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1072\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000397225000012"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27643535"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27643535", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1002/pbc.26259"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/pbc.26259", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: Uyen, T. N., Sakashita, K., Al-Kzayer, L. F. Y., Nakazawa, Y., Kurata, T. and Koike, K. (2017), Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer, 64: n/a, e26259. , which has been published in final form at https://doi.org/10.1002/pbc.26259. 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We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. Procedure: We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation status of each individual gene was then determined by a combination of bisulfite restriction analysis and genome bisulfite sequencing. mRNAexpression was evaluated by reverse-transcriptase PCR (RT-PCR) and quantitative real-time PCR. Results: Cadherin superfamily genes including cadherin (CDH) 1, protocadherin (PCDH) 8, and PCDH17 were selected for analysis of methylation status. In 40 patient samples with B-cell precursor (BCP) ALL at diagnosis, the methylation frequencies of CDH1, PCDH8, and PCDH17 were 62.5, 55, and 30%, respectively. CDH1 and PCDH8 methylation was also detected in 80 and 20% of control bone marrow (BM) samples, respectively. On the contrary, PCDH17 was unmethylated in all control BM samples. There was a significant correlation between the methylation status of PCDH17 (but not CDH1 and PCDH8) and event-free survival or overall survival. Univariate and multivariate analyses showed that only PCDH17 methylation was associated with an increased risk for relapse and mortality in patients with BCP ALL. Conclusion: PCDH17 methylation at diagnosis was closely related to poor prognosis and thus could be used as a new biomarker to predict relapse in patients with BCP ALL."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "LE, THANH NHA UYEN"}], "nameIdentifiers": [{"nameIdentifier": "103706", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "12MH044A_shinsa.pdf", "filesize": [{"value": "116.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 116600.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18972/files/12MH044A_shinsa.pdf"}, "version_id": "f68ede69-df8a-4fe0-933e-4550ffec684d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "12MH044A_yoshi.pdf", "filesize": [{"value": "133.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 133300.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18972/files/12MH044A_yoshi.pdf"}, "version_id": "c28a964c-0b5b-4db5-a306-af4cdaa054c6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "12MH044A_ronbun.pdf", "filesize": [{"value": "771.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is the peer reviewed version of the following article: Uyen, T. 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Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討)
http://hdl.handle.net/10091/00019734
9965428a-c666-4889-82e3-14f4c2721f6c
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-06-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
著者 |
LE, THANH NHA UYEN
× LE, THANH NHA UYEN |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | LE THANH NHA UYEN. Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia(小児急性リンパ性白血病におけるプロトカドヘリン17遺伝子の異常メチル化と予後因子としての有用性の検討). 信州大学, 2016, 博士論文. | |||||
書誌情報 |
発行日 2016-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1072号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
Doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1072号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。PEDIATRIC BLOOD & CANCER. 64(3):e26259 (2017); doi:10.1002/pbc.26259. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27643535 | |||||
関連名称 | ||||||
関連名称 | 27643535 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/pbc.26259 | |||||
関連名称 | ||||||
関連名称 | 10.1002/pbc.26259 | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Uyen, T. N., Sakashita, K., Al-Kzayer, L. F. Y., Nakazawa, Y., Kurata, T. and Koike, K. (2017), Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer, 64: n/a, e26259. , which has been published in final form at https://doi.org/10.1002/pbc.26259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000397225000012 |