Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2017-09-20 |
タイトル |
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タイトル |
Importance of Fatty Acid Compositions in Patients with Peripheral Arterial Disease |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0107003 |
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関連名称 |
10.1371/journal.pone.0107003 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Gautam, Milan
Izawa, Atsushi
Shiba, Yuji
Motoki, Hirohiko
Takeuchi, Takahiro
Okada, Ayako
Tomita, Takeshi
Miyashita, Yusuke
Koyama, Jun
Ikeda, Uichi
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信州大学研究者総覧へのリンク |
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氏名 |
Izawa, Atsushi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yNnVgpkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Shiba, Yuji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZCnmumkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Motoki, Hirohiko |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymfFgpkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Okada, Ayako |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZUnNPUym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Miyashita, Yusuke |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yUfmgpkh.html |
出版者 |
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出版者 |
PUBLIC LIBRARY SCIENCE |
引用 |
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内容記述 |
PLOS ONE. 9(9):e107003 (2014) |
書誌情報 |
PLOS ONE
巻 9,
号 9,
p. e107003,
発行日 2014-09-05
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抄録 |
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内容記述 |
Objective: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Methods: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI <= 0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2 +/- 0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. Results: The presence of PAD (mean ABI: 0.71 +/- 0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85-0.96; P = 0.002), eicosapentaenoic acid: arachidonic acid (EPA: AA) ratio (OR: 0.38; 95% CI: 0.17-0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96-0.98; P<0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06-1.69; P = 0.013). Individuals with lower levels of GLA (<= 7.95 mu g/mL) and a lower EPA: AA ratio (<= 0.55) had the lowest ABI (0.96 +/- 0.02, N = 90), while the highest ABI (1.12 +/- 0.01, N = 78) was observed in individuals with higher values of both GLA and EPA: AA ratio (P<0.0001). Conclusion: A low level of GLA and a low EPA: AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1932-6203 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/25191963 |
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関連名称 |
25191963 |
権利 |
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権利情報 |
© 2014 Gautam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000347993600086 |