{"_buckets": {"deposit": "e229d9df-a5cb-4fd4-992e-e4755b889439"}, "_deposit": {"id": "19067", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19067"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019067", "sets": ["462"]}, "author_link": ["104011", "104012", "104013", "104014", "104015", "104016", "104017", "104018", "104019", "104020"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-09-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageStart": "e107003", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "PLOS ONE"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Methods: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI \u003c= 0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2 +/- 0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. Results: The presence of PAD (mean ABI: 0.71 +/- 0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85-0.96; P = 0.002), eicosapentaenoic acid: arachidonic acid (EPA: AA) ratio (OR: 0.38; 95% CI: 0.17-0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96-0.98; P\u003c0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06-1.69; P = 0.013). Individuals with lower levels of GLA (\u003c= 7.95 mu g/mL) and a lower EPA: AA ratio (\u003c= 0.55) had the lowest ABI (0.96 +/- 0.02, N = 90), while the highest ABI (1.12 +/- 0.01, N = 78) was observed in individuals with higher values of both GLA and EPA: AA ratio (P\u003c0.0001). Conclusion: A low level of GLA and a low EPA: AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "PLOS ONE. 9(9):e107003 (2014)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Izawa, Atsushi", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yNnVgpkh.html"}, {"subitem_link_text": "Shiba, Yuji", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZCnmumkh.html"}, {"subitem_link_text": "Motoki, Hirohiko", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ymfFgpkh.html"}, {"subitem_link_text": "Okada, Ayako", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZUnNPUym.html"}, {"subitem_link_text": "Miyashita, Yusuke", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yUfmgpkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000347993600086"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "PUBLIC LIBRARY SCIENCE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "25191963"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/25191963", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1371/journal.pone.0107003"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1371/journal.pone.0107003", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2014 Gautam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CORONARY-HEART-DISEASE; GAMMA-LINOLENIC ACID; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK-FACTORS; CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN; EICOSAPENTAENOIC ACID; SERUM N-3; HYPERCHOLESTEROLEMIC PATIENTS; MYOCARDIAL-INFARCTION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Objective: Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Methods: Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI \u003c= 0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2 +/- 0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. Results: The presence of PAD (mean ABI: 0.71 +/- 0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85-0.96; P = 0.002), eicosapentaenoic acid: arachidonic acid (EPA: AA) ratio (OR: 0.38; 95% CI: 0.17-0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96-0.98; P\u003c0.0001), and with a high hemoglobin A1c level (OR: 1.34; 95% CI: 1.06-1.69; P = 0.013). Individuals with lower levels of GLA (\u003c= 7.95 mu g/mL) and a lower EPA: AA ratio (\u003c= 0.55) had the lowest ABI (0.96 +/- 0.02, N = 90), while the highest ABI (1.12 +/- 0.01, N = 78) was observed in individuals with higher values of both GLA and EPA: AA ratio (P\u003c0.0001). Conclusion: A low level of GLA and a low EPA: AA ratio are independently associated with the presence of PAD. Specific fatty acid abnormalities and imbalances could lead to new strategies for risk stratification and prevention in PAD patients."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Gautam, Milan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izawa, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiba, Yuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motoki, Hirohiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Ayako", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyashita, Yusuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104018", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, Jun", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104019", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, Uichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "104020", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Importance_Fatty_Acid_Compositions_Patients.pdf", "filesize": [{"value": "361.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright © 2014 Gautam et al. 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