WEKO3
アイテム
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Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice
http://hdl.handle.net/10091/00020112
http://hdl.handle.net/10091/000201124ac6c191-7b2a-4768-8b43-27ec009c4f4e
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-28 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adrenomedullin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | receptor activity-modifying proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | knockout mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphangiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelial cell | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shindo, Takayuki
× Shindo, Takayuki× Sakurai, Takayuki× Kamiyoshi, Akiko× Ichikawa-Shindo, Yuka× Shimoyama, Natsumi× Iinuma, Nobuyoshi× Arai, Takuma× Miyagawa, Shinichi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Shindo, Takayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Sakurai, Takayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kamiyoshi, Akiko | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html | |||||
出版者 | ||||||
出版者 | BENTHAM SCIENCE PUBL LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013) | |||||
書誌情報 |
CURRENT PROTEIN & PEPTIDE SCIENCE 巻 14, 号 5, p. 347-357, 発行日 2013-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1389-2037 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11692455 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/23745699 | |||||
関連名称 | 23745699 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2174/13892037113149990052 | |||||
関連名称 | 10.2174/13892037113149990052 | |||||
権利 | ||||||
権利情報 | © 2013 Bentham Science Publishers | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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