| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-28 |
| タイトル |
|
|
タイトル |
Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice |
| 言語 |
|
|
言語 |
jpn |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.2174/13892037113149990052 |
|
|
関連名称 |
10.2174/13892037113149990052 |
| キーワード |
|
|
主題 |
Adrenomedullin, receptor activity-modifying proteins, knockout mouse, angiogenesis, lymphangiogenesis, endothelial cell |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Shindo, Takayuki
Sakurai, Takayuki
Kamiyoshi, Akiko
Ichikawa-Shindo, Yuka
Shimoyama, Natsumi
Iinuma, Nobuyoshi
Arai, Takuma
Miyagawa, Shinichi
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Shindo, Takayuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Sakurai, Takayuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kamiyoshi, Akiko |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html |
| 出版者 |
|
|
出版者 |
BENTHAM SCIENCE PUBL LTD |
| 引用 |
|
|
内容記述 |
CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013) |
| 書誌情報 |
CURRENT PROTEIN & PEPTIDE SCIENCE
巻 14,
号 5,
p. 347-357,
発行日 2013-08
|
| 抄録 |
|
|
内容記述 |
Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1389-2037 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11692455 |
| PubMed |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/23745699 |
|
|
関連名称 |
23745699 |
| 権利 |
|
|
権利情報 |
© 2013 Bentham Science Publishers |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000324167600001 |
Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf (1.7 MB)
