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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice

http://hdl.handle.net/10091/00020112
http://hdl.handle.net/10091/00020112
4ac6c191-7b2a-4768-8b43-27ec009c4f4e
名前 / ファイル ライセンス アクション
Regulation_ Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-28
タイトル
タイトル Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice
言語
言語 jpn
DOI
関連識別子 https://doi.org/10.2174/13892037113149990052
関連名称 10.2174/13892037113149990052
キーワード
主題 Adrenomedullin, receptor activity-modifying proteins, knockout mouse, angiogenesis, lymphangiogenesis, endothelial cell
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shindo, Takayuki

× Shindo, Takayuki

en Shindo, Takayuki

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Sakurai, Takayuki

× Sakurai, Takayuki

en Sakurai, Takayuki

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Kamiyoshi, Akiko

× Kamiyoshi, Akiko

en Kamiyoshi, Akiko

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Ichikawa-Shindo, Yuka

× Ichikawa-Shindo, Yuka

en Ichikawa-Shindo, Yuka

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Shimoyama, Natsumi

× Shimoyama, Natsumi

en Shimoyama, Natsumi

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Iinuma, Nobuyoshi

× Iinuma, Nobuyoshi

en Iinuma, Nobuyoshi

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Arai, Takuma

× Arai, Takuma

en Arai, Takuma

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Miyagawa, Shinichi

× Miyagawa, Shinichi

en Miyagawa, Shinichi

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信州大学研究者総覧へのリンク
氏名 Shindo, Takayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html
信州大学研究者総覧へのリンク
氏名 Sakurai, Takayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html
信州大学研究者総覧へのリンク
氏名 Kamiyoshi, Akiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html
出版者
出版者 BENTHAM SCIENCE PUBL LTD
引用
内容記述 CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013)
書誌情報 CURRENT PROTEIN & PEPTIDE SCIENCE

巻 14, 号 5, p. 347-357, 発行日 2013-08
抄録
内容記述 Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1389-2037
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11692455
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/23745699
関連名称 23745699
権利
権利情報 © 2013 Bentham Science Publishers
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000324167600001
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