WEKO3
アイテム
Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice
http://hdl.handle.net/10091/00020112
http://hdl.handle.net/10091/000201124ac6c191-7b2a-4768-8b43-27ec009c4f4e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Regulation_ Adrenomedullin_its_Family_Peptide_RAMP_System.pdf (1.7 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-12-28 | |||||
| タイトル | ||||||
| タイトル | Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2174/13892037113149990052 | |||||
| 関連名称 | 10.2174/13892037113149990052 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Adrenomedullin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | receptor activity-modifying proteins | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | knockout mouse | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | angiogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lymphangiogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelial cell | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shindo, Takayuki
× Shindo, Takayuki× Sakurai, Takayuki× Kamiyoshi, Akiko× Ichikawa-Shindo, Yuka× Shimoyama, Natsumi× Iinuma, Nobuyoshi× Arai, Takuma× Miyagawa, Shinichi |
|||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Shindo, Takayuki | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Sakurai, Takayuki | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kamiyoshi, Akiko | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html | |||||
| 出版者 | ||||||
| 出版者 | BENTHAM SCIENCE PUBL LTD | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013) | |||||
| 書誌情報 |
CURRENT PROTEIN & PEPTIDE SCIENCE 巻 14, 号 5, p. 347-357, 発行日 2013-08 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1389-2037 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11692455 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/23745699 | |||||
| 関連名称 | 23745699 | |||||
| 権利 | ||||||
| 権利情報 | © 2013 Bentham Science Publishers | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000324167600001 | |||||
