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Myogenetic Oligodeoxynucleotide Restores Differentiation and Reverses Inflammation of Myoblasts Aggravated by Cancer-Conditioned Medium
http://hdl.handle.net/10091/0002001061
http://hdl.handle.net/10091/0002001061ee3b5e87-7984-4734-968b-f1fe5917865b
| 名前 / ファイル | ライセンス | アクション |
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Muscles1-111.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2022-09-13 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Myogenetic Oligodeoxynucleotide Restores Differentiation and Reverses Inflammation of Myoblasts Aggravated by Cancer-Conditioned Medium | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 関連識別子 | https://doi.org/10.3390/muscles1020012 | |||||||||||||
| 関連名称 | 10.3390/muscles1020012 | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | aptamer, cachexia, inflammatory response, myoblast, myogenetic oligodeoxynucleotide, myogenic differentiation | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | journal article | |||||||||||||
| 著者 |
Nihashi, Yuma
× Nihashi, Yuma
× Yamamoto, Machi
× Shimosato, Takeshi
× Takaya, Tomohide
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| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | 下里, 剛士 | |||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html | |||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | 高谷, 智英 | |||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | MDPI | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | Muscles. 1(2) : 111-120 (2022) | |||||||||||||
| 書誌情報 |
en : Muscles 巻 1, 号 2, p. 111-120, 発行日 2022-09-09 |
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| 抄録 | ||||||||||||||
| 内容記述 | Cancer cachexia is characterized by irreversible muscle loss which is a critical factor in the prognosis of cancer patients. Myoblasts are myogenic precursor cells that are required to maintain skeletal muscle tissue. Previous studies reported that cancer-released factors deteriorate myoblast differentiation, which is one of the causes of cachexia-associated muscle wasting. We recently identified the myogenetic oligodeoxynucleotide, iSN04, which serves as an anti-nucleolin aptamer and promotes myogenesis. The present study investigated the effects of iSN04 on human myoblasts exposed to a conditioned medium (CM) of cancer cells. CM of colon cancer cell lines LoVo and HCT-116 significantly impaired myogenic differentiation and the myotube formation of human myoblasts by inducing the expression of inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor-α (TNF-α); however, the CM of the colon fibroblast cell line CCD-18Co did not. Intriguingly, iSN04 completely reversed the deterioration of myoblast differentiation by LoVo-CM by upregulating MyoD and myogenin, and downregulating myostatin, IL-1β, and TNF-α. TNF-α, of which a high level was produced in LoVo, alone inhibited myogenic differentiation and induced IL-1β, IL-6, and IL-8 transcriptions of myoblasts; however, pre-treatment with iSN04 reversed TNF-α-induced cachectic phenotypic features. The results indicate that iSN04 protects myoblasts against the effects of cancer-released factors and maintains their myogenic activity. This study provides a novel therapeutic strategy to prevent muscle loss associated with cancer cachexia. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2813-0413 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報Resource | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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Nihashi, Yuma, Yamamoto, Machi, Shimosato, Takeshi, Takaya, Tomohide, 2022, Myogenetic Oligodeoxynucleotide Restores Differentiation and Reverses Inflammation of Myoblasts Aggravated by Cancer-Conditioned Medium: MDPI, 111–120 p.
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