{"_buckets": {"deposit": "5a9cf565-0fcc-49a4-a58f-50a447183e51"}, "_deposit": {"id": "2001244", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001244"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02001244", "sets": ["462"]}, "author_link": [], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-11-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "1069", "bibliographicPageStart": "1057", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "JACC. Basic to translational science"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca2+ channels through angiotensin type 1 receptor (AT1R) and β-arrestin. TRV027, a β-arrestin-biased AT1R agonist, that has been reported to be safe but not effective for adult patients with heart failure, activates the AT1R/β-arrestin pathway. We found that TRV027 evokes a long-acting positive inotropic effect specifically on immature cardiac myocytes through the AT1R/β-arrestin/L-type Ca2+ channel pathway with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone secretion. Thus, TRV027 could be utilized as a valuable drug specific for pediatric heart failure.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JACC. Basic to translational science 5(11) : 1057-1069(2020)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "川岸, 裕幸", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.Zefaumkh.html"}, {"subitem_link_text": "中田, 勉", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html"}, {"subitem_link_text": "冨田, 拓郎", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OpTCumDV.html"}, {"subitem_link_text": "門田, 真", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OaSaPNym.html"}, {"subitem_link_text": "山田, 充彦", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "33294739"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/33294739/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.jacbts.2020.08.011"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jacbts.2020.08.011", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2452-302X", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2452-302X", "subitem_source_identifier_type": "EISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kashihara, Toshihide", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawagishi, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakada, Tsutomu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Numaga-Tomita, Takuro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kadota, Shin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wolf, Elena E.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Du, Cheng-Kun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shiba, Yuji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Morimoto, Sachio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamada, Mitsuhiko", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-12-01"}], "download_preview_message": "", "file_order": 0, "filename": "18K06870_1.pdf", "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 0, "url": {"label": "18K06870_1.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2001244/files/18K06870_1.pdf"}, "version_id": "c21e57ff-4c7b-46d5-afb1-647a30078d61"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "β-arrestin–biased AT1 angiotensin receptor agonist", "subitem_subject_scheme": "Other"}, {"subitem_subject": "congenital dilated cardiomyopathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human induced pluripotent stem cell-derived cardiac myocytes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "inotropic vasodilator", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neonate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pediatric heart failure", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TRV027", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/0002001244", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-12-01"}, "publish_date": "2022-12-01", "publish_status": "0", "recid": "2001244", "relation": {}, "relation_version_is_last": true, "title": ["β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate"], "weko_shared_id": -1}