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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism

http://hdl.handle.net/10091/0002001269
http://hdl.handle.net/10091/0002001269
41b04055-9368-4cbb-a2d8-4c85c478dac0
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18H02602_2.pdf 18H02602_2.pdf
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-01-19
タイトル
タイトル Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
言語
言語 eng
DOI
関連タイプ isIdenticalTo
関連識別子 https://doi.org/10.1016/j.heliyon.2019.e01637
関連名称 10.1016/j.heliyon.2019.e01637
キーワード
主題 Molecular biology
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yamauchi, Akihiro

× Yamauchi, Akihiro

en Yamauchi, Akihiro

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Kamiyoshi, Akiko

× Kamiyoshi, Akiko

en Kamiyoshi, Akiko

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Sakurai, Takayuki

× Sakurai, Takayuki

en Sakurai, Takayuki

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Miyazaki, Hiroyuki

× Miyazaki, Hiroyuki

en Miyazaki, Hiroyuki

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Hirano, Eiichi

× Hirano, Eiichi

en Hirano, Eiichi

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Lim, Hong Seok

× Lim, Hong Seok

en Lim, Hong Seok

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Kaku, Taiichi

× Kaku, Taiichi

en Kaku, Taiichi

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Shindo, Takayuki

× Shindo, Takayuki

en Shindo, Takayuki

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信州大学研究者総覧へのリンク
氏名 神吉, 昭子
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html
信州大学研究者総覧へのリンク
氏名 桜井, 敬之
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html
信州大学研究者総覧へのリンク
氏名 新藤, 隆行
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html
出版者
出版者 Elsevier
引用
内容記述 Heliyon 5(5) : e01637-(2019)
書誌情報 Heliyon

巻 5, 号 5, p. e01637, 発行日 2019-05-10
抄録
内容記述 Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and choline-deficient (MCD) diet with an iron-overload diet. Using this model, we evaluated the effects of human placenta extract (HPE), which has been shown to ameliorate the pathology of NASH. Four-week-old male C57BL/6 mice were fed the MCD diet with 2% iron for 12 weeks. In liver sections, iron deposition was first detected around the portal vein after 1 week. From there it spread throughout the parenchyma. Biliary iron concentrations were continuously elevated throughout the entire 12-week diet. As a compensatory response, the diet caused elevation of serum hepcidin, which accelerates excretion of iron from the body. Accumulation of F4/80-positive macrophages was detected within the sinusoids from the first week onward, and real-time PCR analysis revealed elevated hepatic expression of genes related inflammation and oxidative stress. In the model mice, HPE treatment led to a marked reduction of hepatic iron deposition with a corresponding increase in biliary iron excretion. Macrophage accumulation was much reduced by HPE treatment, as was the serum oxidation-reduction potential, an index of oxidative stress. These data indicate that by suppressing inflammation, oxidative stress and iron deposition, and enhancing iron excretion, HPE effectively ameliorates iron overload-induced liver injury. HPE administration may thus be an effective strategy for treating NASH.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 2405-8440
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/31193082/
関連名称 31193082
権利
権利情報 © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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Yamauchi, Akihiro, Kamiyoshi, Akiko, Sakurai, Takayuki, Miyazaki, Hiroyuki, Hirano, Eiichi, Lim, Hong Seok, Kaku, Taiichi, Shindo, Takayuki, 2019, Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism: Elsevier, e01637– p.

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