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Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
http://hdl.handle.net/10091/0002001269
http://hdl.handle.net/10091/000200126941b04055-9368-4cbb-a2d8-4c85c478dac0
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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公開日 | 2023-01-19 | |||||||||||||||||||||
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タイトル | Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism | |||||||||||||||||||||
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言語 | eng | |||||||||||||||||||||
DOI | ||||||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||||||
関連識別子 | https://doi.org/10.1016/j.heliyon.2019.e01637 | |||||||||||||||||||||
関連名称 | 10.1016/j.heliyon.2019.e01637 | |||||||||||||||||||||
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主題 | Molecular biology | |||||||||||||||||||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
タイプ | journal article | |||||||||||||||||||||
著者 |
Yamauchi, Akihiro
× Yamauchi, Akihiro
× Kamiyoshi, Akiko
× Sakurai, Takayuki
× Miyazaki, Hiroyuki
× Hirano, Eiichi
× Lim, Hong Seok
× Kaku, Taiichi
× Shindo, Takayuki
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信州大学研究者総覧へのリンク | ||||||||||||||||||||||
氏名 | 神吉, 昭子 | |||||||||||||||||||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html | |||||||||||||||||||||
信州大学研究者総覧へのリンク | ||||||||||||||||||||||
氏名 | 桜井, 敬之 | |||||||||||||||||||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html | |||||||||||||||||||||
信州大学研究者総覧へのリンク | ||||||||||||||||||||||
氏名 | 新藤, 隆行 | |||||||||||||||||||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html | |||||||||||||||||||||
出版者 | ||||||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||||||
引用 | ||||||||||||||||||||||
内容記述 | Heliyon 5(5) : e01637-(2019) | |||||||||||||||||||||
書誌情報 |
Heliyon 巻 5, 号 5, p. e01637, 発行日 2019-05-10 |
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内容記述 | Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and choline-deficient (MCD) diet with an iron-overload diet. Using this model, we evaluated the effects of human placenta extract (HPE), which has been shown to ameliorate the pathology of NASH. Four-week-old male C57BL/6 mice were fed the MCD diet with 2% iron for 12 weeks. In liver sections, iron deposition was first detected around the portal vein after 1 week. From there it spread throughout the parenchyma. Biliary iron concentrations were continuously elevated throughout the entire 12-week diet. As a compensatory response, the diet caused elevation of serum hepcidin, which accelerates excretion of iron from the body. Accumulation of F4/80-positive macrophages was detected within the sinusoids from the first week onward, and real-time PCR analysis revealed elevated hepatic expression of genes related inflammation and oxidative stress. In the model mice, HPE treatment led to a marked reduction of hepatic iron deposition with a corresponding increase in biliary iron excretion. Macrophage accumulation was much reduced by HPE treatment, as was the serum oxidation-reduction potential, an index of oxidative stress. These data indicate that by suppressing inflammation, oxidative stress and iron deposition, and enhancing iron excretion, HPE effectively ameliorates iron overload-induced liver injury. HPE administration may thus be an effective strategy for treating NASH. | |||||||||||||||||||||
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収録物識別子タイプ | EISSN | |||||||||||||||||||||
収録物識別子 | 2405-8440 | |||||||||||||||||||||
PubMed | ||||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/31193082/ | |||||||||||||||||||||
関連名称 | 31193082 | |||||||||||||||||||||
権利 | ||||||||||||||||||||||
権利情報 | © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||
出版タイプ | ||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Cite as
Yamauchi, Akihiro, Kamiyoshi, Akiko, Sakurai, Takayuki, Miyazaki, Hiroyuki, Hirano, Eiichi, Lim, Hong Seok, Kaku, Taiichi, Shindo, Takayuki, 2019, Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism: Elsevier, e01637– p.
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