{"_buckets": {"deposit": "aeedc464-4359-43c0-ae9e-7a2445a4c53f"}, "_deposit": {"id": "2001269", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001269"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02001269", "sets": []}, "author_link": [], "control_number": "2001269", "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-05-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageStart": "e01637", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "Heliyon"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and choline-deficient (MCD) diet with an iron-overload diet. Using this model, we evaluated the effects of human placenta extract (HPE), which has been shown to ameliorate the pathology of NASH. Four-week-old male C57BL/6 mice were fed the MCD diet with 2% iron for 12 weeks. In liver sections, iron deposition was first detected around the portal vein after 1 week. From there it spread throughout the parenchyma. Biliary iron concentrations were continuously elevated throughout the entire 12-week diet. As a compensatory response, the diet caused elevation of serum hepcidin, which accelerates excretion of iron from the body. Accumulation of F4/80-positive macrophages was detected within the sinusoids from the first week onward, and real-time PCR analysis revealed elevated hepatic expression of genes related inflammation and oxidative stress. In the model mice, HPE treatment led to a marked reduction of hepatic iron deposition with a corresponding increase in biliary iron excretion. Macrophage accumulation was much reduced by HPE treatment, as was the serum oxidation-reduction potential, an index of oxidative stress. These data indicate that by suppressing inflammation, oxidative stress and iron deposition, and enhancing iron excretion, HPE effectively ameliorates iron overload-induced liver injury. HPE administration may thus be an effective strategy for treating NASH.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Heliyon 5(5) : e01637-(2019)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "神吉, 昭子", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html"}, {"subitem_link_text": "桜井, 敬之", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html"}, {"subitem_link_text": "新藤, 隆行", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "31193082"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/31193082/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.heliyon.2019.e01637"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.heliyon.2019.e01637", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2405-8440", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2405-8440", "subitem_source_identifier_type": "EISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamauchi, Akihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kamiyoshi, Akiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sakurai, Takayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hirano, Eiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Lim, Hong Seok", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kaku, Taiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shindo, Takayuki", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-01-19"}], "download_preview_message": "", "file_order": 0, "filename": "18H02602_2.pdf", "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 The Authors. 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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).", "licensetype": "license_0", "mimetype": "application/pdf", "size": 0, "url": {"label": "18H02602_2.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2001269/files/18H02602_2.pdf"}, "version_id": "4cd55197-394e-42dc-8220-ef7d420b251f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Molecular biology", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/0002001269", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-01-19"}, "publish_date": "2023-01-19", "publish_status": "0", "recid": "2001269", "relation": {}, "relation_version_is_last": true, "title": ["Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism"], "weko_shared_id": -1}
Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
http://hdl.handle.net/10091/0002001269
http://hdl.handle.net/10091/0002001269