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Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
http://hdl.handle.net/10091/0002001279
http://hdl.handle.net/10091/0002001279171421ae-3368-49b6-89aa-66575e8f1bb1
| 名前 / ファイル | ライセンス | アクション |
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17K19900_3.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2023-01-26 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1155/2018/3181759 | |||||||||||||||||||||||
| 関連名称 | 10.1155/2018/3181759 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Huo, Jia
× Huo, Jia
× Xu, Zhe
× Hosoe, Kazunori
× Kubo, Hiroshi
× Miyahara, Hiroki
× Dai, Jian
× Mori, Masayuki
× Sawashita, Jinko
× Higuchi, Keiichi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 宮原, 大貴 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 代, 健 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 森, 政之 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 樋口, 京一 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Hindawi Ltd. | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | Oxidative medicine and cellular longevity 2018 : 3181759, (2018) | |||||||||||||||||||||||
| 書誌情報 |
Oxidative medicine and cellular longevity 巻 2018, p. 3181759, 発行日 2018-07-08 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Oxidative damage in endothelial cells is proposed to play an important role in endothelial dysfunction and atherogenesis. We previously reported that the reduced form of coenzyme Q10 (CoQ10H2) effectively inhibits oxidative stress and decelerates senescence in senescence-accelerated mice. Here, we treated human umbilical vein endothelial cells (HUVECs) with H2O2 and investigated the protective effect of CoQ10H2 against senescence, oxidative damage, and reduction in cellular functions. We found that CoQ10H2 markedly reduced the number of senescence-associated β-galactosidase-positive cells and suppressed the expression of senescence-associated secretory phenotype-associated genes in H2O2-treated HUVECs. Furthermore, CoQ10H2 suppressed the generation of intracellular reactive oxygen species (ROS) but promoted NO production that was accompanied by increased eNOS expression. CoQ10H2 prevented apoptosis and reductions in mitochondrial function and reduced migration and tube formation activity of H2O2-treated cells. The present study indicated that CoQ10H2 protects endothelial cells against senescence by promoting mitochondrial function and thus could delay vascular aging. | |||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||
| 収録物識別子 | 1942-0994 | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/30116476/ | |||||||||||||||||||||||
| 関連名称 | 30116476 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | © 2018 Jia Huo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
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Huo, Jia, Xu, Zhe, Hosoe, Kazunori, Kubo, Hiroshi, Miyahara, Hiroki, Dai, Jian, Mori, Masayuki, Sawashita, Jinko, Higuchi, Keiichi, 2018, Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells: Hindawi Ltd., 3181759– p.
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