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Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway
http://hdl.handle.net/10091/0002001447
http://hdl.handle.net/10091/0002001447b16868bc-fd08-4611-b6cb-3e5faa980b11
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBRC664_1.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2023-05-08 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2023.04.098 | |||||||||||||||
| 関連名称 | 10.1016/j.bbrc.2023.04.098 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | β-catenin, Inflammatory response, Myoblast, Myogenetic oligodeoxynucleotide (myoDN), Nuclear factor-kB (NF-kB), Nucleolin | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
Yamamoto, Machi
× Yamamoto, Machi
× Miyoshi, Mana
× Morioka, Kamino
× Mitani, Takakazu
× Takaya, Tomohide
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| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | 三谷, 塁一 | |||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html | |||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | 高谷, 智英 | |||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | Biochemical and biophysical research communications 664 : 1-8, (2023) | |||||||||||||||
| 書誌情報 |
en : Biochemical and biophysical research communications 巻 664, p. 1-8, 発行日 2023-04-26 |
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| 抄録 | ||||||||||||||||
| 内容記述 | A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated from patients with diabetes or healthy myoblasts exposed to cancer-releasing factors. Thus, iSN04 is expected to be a nucleic acid drug for the muscle wasting associated with chronic diseases. The present study investigated the anti-inflammatory mechanism of iSN04 in the murine myoblast cell line C2C12. Tumor necrosis factor-α (TNF-α) or Toll-like receptor (TLR) ligands (Pam3CSK4 and FSL-1) induced nuclear translocation and transcriptional activity of nuclear factor-κB (NF-κB), resulting in upregulated expression of TNF-α and interleukin-6. Pre-treatment with iSN04 significantly suppressed these inflammatory responses by inhibiting the nuclear accumulation of β-catenin induced by TNF-α or TLR ligands. These results demonstrate that antagonizing nucleolin with iSN04 downregulates the inflammatory effect mediated by the β-catenin/NF-κB signaling pathway in C2C12 cells. In addition, the anti-inflammatory effects of iSN04 were also observed in the rat smooth muscle cell line A10 and the murine adipocyte-like fibroblast cell line 3T3-L1, suggesting that iSN04 may be useful in preventing inflammation induced by metabolic disorders. | |||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 1090-2104 | |||||||||||||||
| PubMed | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/37127012/ | |||||||||||||||
| 関連名称 | 37127012 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
