| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-05-08 |
| タイトル |
|
|
タイトル |
Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2023.04.098 |
|
|
関連名称 |
10.1016/j.bbrc.2023.04.098 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
β-catenin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Inflammatory response |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Myoblast |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Myogenetic oligodeoxynucleotide (myoDN) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Nuclear factor-kB (NF-kB) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Nucleolin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yamamoto, Machi
Miyoshi, Mana
Morioka, Kamino
Mitani, Takakazu
Takaya, Tomohide
|
| 信州大学研究者総覧へのリンク |
|
|
表示名 |
三谷, 塁一 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html |
| 信州大学研究者総覧へのリンク |
|
|
表示名 |
高谷, 智英 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html |
| 出版者 |
|
|
出版者 |
Elsevier |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Biochemical and biophysical research communications 664 : 1-8, (2023) |
| 書誌情報 |
en : Biochemical and biophysical research communications
巻 664,
p. 1-8,
発行日 2023-04-26
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated from patients with diabetes or healthy myoblasts exposed to cancer-releasing factors. Thus, iSN04 is expected to be a nucleic acid drug for the muscle wasting associated with chronic diseases. The present study investigated the anti-inflammatory mechanism of iSN04 in the murine myoblast cell line C2C12. Tumor necrosis factor-α (TNF-α) or Toll-like receptor (TLR) ligands (Pam3CSK4 and FSL-1) induced nuclear translocation and transcriptional activity of nuclear factor-κB (NF-κB), resulting in upregulated expression of TNF-α and interleukin-6. Pre-treatment with iSN04 significantly suppressed these inflammatory responses by inhibiting the nuclear accumulation of β-catenin induced by TNF-α or TLR ligands. These results demonstrate that antagonizing nucleolin with iSN04 downregulates the inflammatory effect mediated by the β-catenin/NF-κB signaling pathway in C2C12 cells. In addition, the anti-inflammatory effects of iSN04 were also observed in the rat smooth muscle cell line A10 and the murine adipocyte-like fibroblast cell line 3T3-L1, suggesting that iSN04 may be useful in preventing inflammation induced by metabolic disorders. |
| 資源タイプ（コンテンツの種類） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Article |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1090-2104 |
| PubMed |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/37127012/ |
|
|
関連名称 |
37127012 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
BBRC664_1.pdf
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