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Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results.We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (????P \u003c 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (????P \u003c 0.01, for both).The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (????P \u003c 0.01, for both). 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome

http://hdl.handle.net/10091/00020849
f7bf8086-ed31-47af-9d12-d51bfefe51d0
名前 / ファイル ライセンス アクション
25293063_17.pdf 25293063_17.pdf (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-12
タイトル
言語 en
タイトル Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Misaka, T

× Misaka, T

WEKO 106223

en Misaka, T

Search repository
Suzuki, S

× Suzuki, S

WEKO 106224

en Suzuki, S

Search repository
Sakamoto, N

× Sakamoto, N

WEKO 106225

en Sakamoto, N

Search repository
Yamaki, T

× Yamaki, T

WEKO 106226

en Yamaki, T

Search repository
Sugimoto, K

× Sugimoto, K

WEKO 106227

en Sugimoto, K

Search repository
Kunii, H

× Kunii, H

WEKO 106228

en Kunii, H

Search repository
Nakazato, K

× Nakazato, K

WEKO 106229

en Nakazato, K

Search repository
Saitoh, S

× Saitoh, S

WEKO 106230

en Saitoh, S

Search repository
Sawamura, T

× Sawamura, T

WEKO 106231

en Sawamura, T

Search repository
Ishibashi, T

× Ishibashi, T

WEKO 106232

en Ishibashi, T

Search repository
Takeishi, Y

× Takeishi, Y

WEKO 106233

en Takeishi, Y

Search repository
信州大学研究者総覧へのリンク
氏名 Sawamura, Tatsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 BIOMED RESEARCH INTERNATIONAL.2014:649185(2014)
書誌情報 BIOMED RESEARCH INTERNATIONAL

巻 2014, p. 649185, 発行日 2014-05-07
抄録
内容記述タイプ Abstract
内容記述 Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results.We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (????P < 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (????P < 0.01, for both).The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (????P < 0.01, for both). Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the solubleLOX-1 andLOX-1 indexwith no differences between theAo andCS. Conclusions.Thepresent study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 2314-6133
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2014/649185
関連名称
関連名称 10.1155/2014/649185
権利
権利情報 © 2014 Tomofumi Misaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=7&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000336166000001
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