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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis

http://hdl.handle.net/10091/00020858
http://hdl.handle.net/10091/00020858
5599a8f1-3e50-4634-ac93-7edaedcf379e
名前 / ファイル ライセンス アクション
25640028_01.pdf 25640028_01.pdf (728.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-13
タイトル
タイトル Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1002/jnr.23491
関連名称 10.1002/jnr.23491
キーワード
主題 biometal, ER stress, Immunohistochemistry
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kaneko, Masayuki

× Kaneko, Masayuki

en Kaneko, Masayuki

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Noguchi, Takao

× Noguchi, Takao

en Noguchi, Takao

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Ikegami, Saori

× Ikegami, Saori

en Ikegami, Saori

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Sakurai, Takeyuki

× Sakurai, Takeyuki

en Sakurai, Takeyuki

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Kakita, Akiyoshi

× Kakita, Akiyoshi

en Kakita, Akiyoshi

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Toyoshima, Yasuko

× Toyoshima, Yasuko

en Toyoshima, Yasuko

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Kambe, Taiho

× Kambe, Taiho

en Kambe, Taiho

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Yamada, Mitsunori

× Yamada, Mitsunori

en Yamada, Mitsunori

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Inden, Masatoshi

× Inden, Masatoshi

en Inden, Masatoshi

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Hara, Hideaki

× Hara, Hideaki

en Hara, Hideaki

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Oyanagi, Kiyomitsu

× Oyanagi, Kiyomitsu

en Oyanagi, Kiyomitsu

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Inuzuka, Takashi

× Inuzuka, Takashi

en Inuzuka, Takashi

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Takahashi, Hitoshi

× Takahashi, Hitoshi

en Takahashi, Hitoshi

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Hozumi, Isao

× Hozumi, Isao

en Hozumi, Isao

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信州大学研究者総覧へのリンク
氏名 Oyanagi, Kiyomitsu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述 JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)
書誌情報 JOURNAL OF NEUROSCIENCE RESEARCH

巻 93, 号 2, p. 370-379, 発行日 2014-10-03
内容記述
内容記述タイプ Other
内容記述 本文のみを公開。
抄録
内容記述 The loss of homeostasis of essential metals is associated with various diseases, including neurodegenerative diseases. Previous studies have shown that the levels of zinc (Zn) are significantly higher in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). Zn transporters and metallothioneins tightly control intracellular and extracellular Zn levels. This study investigated the protein levels of ZnT, a Zn transporter family, in ALS patients and model mice. The mRNA expression of ZnT1, −3, −4, −5, −6, −7, and −10 was assessed in the spinal cords of human control subjects. ZnT3 and ZnT6 protein levels were significantly diminished in the spinal cords of sporadic ALS patients compared with controls. Furthermore, immunohistochemical staining demonstrated decreased ZnT3 and ZnT6 immunoreactivity in the ventral horn of the spinal cords in ALS patients. Moreover, immunohistochemical analysis revealed that all ZnTs expressed in the spinal cords were localized in a distinct subset of motor neurons. In addition, ZnT3 and ZnT6 protein levels were not altered in SOD1 (G93A) mutant transgenic mice before or after the onset of ALS symptoms compared with controls. These results suggest that ZnT3 and ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients; however, this did not occur merely via loss of motor neurons. © 2014 Wiley Periodicals, Inc.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1097-4547
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11623725
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/25284286
関連名称 25284286
権利
権利情報 This is the peer reviewed version of the following article: [JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)], which has been published in final form at [https://doi.org/10.1002/jnr.23491]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346475600016
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Cite as

Kaneko, Masayuki, Noguchi, Takao, Ikegami, Saori, Sakurai, Takeyuki, Kakita, Akiyoshi, Toyoshima, Yasuko, Kambe, Taiho, Yamada, Mitsunori, Inden, Masatoshi, Hara, Hideaki, Oyanagi, Kiyomitsu, Inuzuka, Takashi, Takahashi, Hitoshi, Hozumi, Isao, 2014, Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis: WILEY-BLACKWELL, 370–379 p.

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