| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-09-13 |
| タイトル |
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|
タイトル |
Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis |
| 言語 |
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|
言語 |
eng |
| DOI |
|
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|
関連識別子 |
https://doi.org/10.1002/jnr.23491 |
|
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関連名称 |
10.1002/jnr.23491 |
| キーワード |
|
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主題 |
biometal, ER stress, Immunohistochemistry |
| 資源タイプ |
|
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Kaneko, Masayuki
Noguchi, Takao
Ikegami, Saori
Sakurai, Takeyuki
Kakita, Akiyoshi
Toyoshima, Yasuko
Kambe, Taiho
Yamada, Mitsunori
Inden, Masatoshi
Hara, Hideaki
Oyanagi, Kiyomitsu
Inuzuka, Takashi
Takahashi, Hitoshi
Hozumi, Isao
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Oyanagi, Kiyomitsu |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html |
| 出版者 |
|
|
出版者 |
WILEY-BLACKWELL |
| 引用 |
|
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内容記述 |
JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014) |
| 書誌情報 |
JOURNAL OF NEUROSCIENCE RESEARCH
巻 93,
号 2,
p. 370-379,
発行日 2014-10-03
|
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
本文のみを公開。 |
| 抄録 |
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内容記述 |
The loss of homeostasis of essential metals is associated with various diseases, including neurodegenerative diseases. Previous studies have shown that the levels of zinc (Zn) are significantly higher in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). Zn transporters and metallothioneins tightly control intracellular and extracellular Zn levels. This study investigated the protein levels of ZnT, a Zn transporter family, in ALS patients and model mice. The mRNA expression of ZnT1, −3, −4, −5, −6, −7, and −10 was assessed in the spinal cords of human control subjects. ZnT3 and ZnT6 protein levels were significantly diminished in the spinal cords of sporadic ALS patients compared with controls. Furthermore, immunohistochemical staining demonstrated decreased ZnT3 and ZnT6 immunoreactivity in the ventral horn of the spinal cords in ALS patients. Moreover, immunohistochemical analysis revealed that all ZnTs expressed in the spinal cords were localized in a distinct subset of motor neurons. In addition, ZnT3 and ZnT6 protein levels were not altered in SOD1 (G93A) mutant transgenic mice before or after the onset of ALS symptoms compared with controls. These results suggest that ZnT3 and ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients; however, this did not occur merely via loss of motor neurons. © 2014 Wiley Periodicals, Inc. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1097-4547 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11623725 |
| PubMed |
|
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/25284286 |
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|
関連名称 |
25284286 |
| 権利 |
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|
権利情報 |
This is the peer reviewed version of the following article: [JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)], which has been published in final form at [https://doi.org/10.1002/jnr.23491]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346475600016 |
25640028_01.pdf (728.1 kB)
